Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*

Context: Amaranth and canola oils have been used traditionally. Amaranth has been identified as being of interest because of its outstanding nutritive value. Amaranth oil is a rich source of highly unsaturated fats and so could be a valuable dietary alternative for individuals affected with obesity....

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Autores principales:	Dominika Kanikowska, Alina Kanikowska, Rafał Rutkowski, Małgorzata Włochal, Zofia Orzechowska, Aldona Juchacz, Agnieszka Zawada, Marian Grzymisławski, Magdalena Roszak, Maki Sato, Andrzej Bręborowicz, Janusz Witowski
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	neutrophil oxidative burst obesity plant oil Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c1bb97e435ed408f9cee5b1cd4cd3493
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spelling	oai:doaj.org-article:c1bb97e435ed408f9cee5b1cd4cd34932021-11-17T14:21:55ZAmaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*1388-02091744-511610.1080/13880209.2019.1569696https://doaj.org/article/c1bb97e435ed408f9cee5b1cd4cd34932019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2019.1569696https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Amaranth and canola oils have been used traditionally. Amaranth has been identified as being of interest because of its outstanding nutritive value. Amaranth oil is a rich source of highly unsaturated fats and so could be a valuable dietary alternative for individuals affected with obesity. Reactive oxygen species (ROS) are postulated to be involved in systemic inflammation and oxidative stress. Activated polymorphonuclear neutrophils (PMNs) generate high amounts of reactive oxygen species. Objective: Our study investigates the impact of amaranth and canola oils supplementation on oxidative metabolism in patients with obesity. We hypothesized that, due to its lipid-lowering and antioxidant properties, amaranth and canola oil would protect against oxidative stress. Materials and methods: We tested 19 obese patients [body mass index (BMI) = 41.1 ± 7.8 kg/m2, (mean ± SD)]. The protocol consisted of two stages: a run-in phase of 2 weeks and an experimental stage – canola or amaranth oil supplementation (20 mL/d) with calorie restriction diet for 3 weeks. The neutrophil oxidative burst was expressed by fluorescence intensity (IF). Results: The oxidative burst had increased significantly at the end of treatment in both groups IF: (21.4 ± 11.15 vs. 35.9 ± 20.3; mean ± SD) p < 0.05. The levels of IF were significantly higher in neutrophils of patients who received canola oil (41.05 ± 25.3) compared to those who received amaranth oil (28.4 ± 11.8) p < 0.05. Conclusions: Canola oil exerts possible effects on oxidative burst activity in neutrophils in vivo conditions.Dominika KanikowskaAlina KanikowskaRafał RutkowskiMałgorzata WłochalZofia OrzechowskaAldona JuchaczAgnieszka ZawadaMarian GrzymisławskiMagdalena RoszakMaki SatoAndrzej BręborowiczJanusz WitowskiTaylor & Francis Grouparticleneutrophil oxidative burstobesityplant oilTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 140-144 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	neutrophil oxidative burst obesity plant oil Therapeutics. Pharmacology RM1-950
spellingShingle	neutrophil oxidative burst obesity plant oil Therapeutics. Pharmacology RM1-950 Dominika Kanikowska Alina Kanikowska Rafał Rutkowski Małgorzata Włochal Zofia Orzechowska Aldona Juchacz Agnieszka Zawada Marian Grzymisławski Magdalena Roszak Maki Sato Andrzej Bręborowicz Janusz Witowski Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*
description	Context: Amaranth and canola oils have been used traditionally. Amaranth has been identified as being of interest because of its outstanding nutritive value. Amaranth oil is a rich source of highly unsaturated fats and so could be a valuable dietary alternative for individuals affected with obesity. Reactive oxygen species (ROS) are postulated to be involved in systemic inflammation and oxidative stress. Activated polymorphonuclear neutrophils (PMNs) generate high amounts of reactive oxygen species. Objective: Our study investigates the impact of amaranth and canola oils supplementation on oxidative metabolism in patients with obesity. We hypothesized that, due to its lipid-lowering and antioxidant properties, amaranth and canola oil would protect against oxidative stress. Materials and methods: We tested 19 obese patients [body mass index (BMI) = 41.1 ± 7.8 kg/m2, (mean ± SD)]. The protocol consisted of two stages: a run-in phase of 2 weeks and an experimental stage – canola or amaranth oil supplementation (20 mL/d) with calorie restriction diet for 3 weeks. The neutrophil oxidative burst was expressed by fluorescence intensity (IF). Results: The oxidative burst had increased significantly at the end of treatment in both groups IF: (21.4 ± 11.15 vs. 35.9 ± 20.3; mean ± SD) p < 0.05. The levels of IF were significantly higher in neutrophils of patients who received canola oil (41.05 ± 25.3) compared to those who received amaranth oil (28.4 ± 11.8) p < 0.05. Conclusions: Canola oil exerts possible effects on oxidative burst activity in neutrophils in vivo conditions.
format	article
author	Dominika Kanikowska Alina Kanikowska Rafał Rutkowski Małgorzata Włochal Zofia Orzechowska Aldona Juchacz Agnieszka Zawada Marian Grzymisławski Magdalena Roszak Maki Sato Andrzej Bręborowicz Janusz Witowski
author_facet	Dominika Kanikowska Alina Kanikowska Rafał Rutkowski Małgorzata Włochal Zofia Orzechowska Aldona Juchacz Agnieszka Zawada Marian Grzymisławski Magdalena Roszak Maki Sato Andrzej Bręborowicz Janusz Witowski
author_sort	Dominika Kanikowska
title	Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*
title_short	Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*
title_full	Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*
title_fullStr	Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*
title_full_unstemmed	Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*
title_sort	amaranth (amaranthus cruentus l.) and canola (brassica napus l.) oil impact on the oxidative metabolism of neutrophils in the obese patients*
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/c1bb97e435ed408f9cee5b1cd4cd3493
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Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*

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