Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein

An efficient vaccine for human metapneumovirus (hMPV) will likely rely on neutralizing antibodies against the fusion protein (F). Here, the authors determine the crystal structure of pre-fusion-stabilized hMPV F and identify a dense glycan shield that affects generation of neutralizing antibodies.

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Autores principales:	Michael B. Battles, Vicente Más, Eduardo Olmedillas, Olga Cano, Mónica Vázquez, Laura Rodríguez, José A. Melero, Jason S. McLellan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1c088aef2e64c7f8c8b3f48886612e5
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spelling	oai:doaj.org-article:c1c088aef2e64c7f8c8b3f48886612e52021-12-02T14:42:05ZStructure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein10.1038/s41467-017-01708-92041-1723https://doaj.org/article/c1c088aef2e64c7f8c8b3f48886612e52017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01708-9https://doaj.org/toc/2041-1723An efficient vaccine for human metapneumovirus (hMPV) will likely rely on neutralizing antibodies against the fusion protein (F). Here, the authors determine the crystal structure of pre-fusion-stabilized hMPV F and identify a dense glycan shield that affects generation of neutralizing antibodies.Michael B. BattlesVicente MásEduardo OlmedillasOlga CanoMónica VázquezLaura RodríguezJosé A. MeleroJason S. McLellanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael B. Battles Vicente Más Eduardo Olmedillas Olga Cano Mónica Vázquez Laura Rodríguez José A. Melero Jason S. McLellan Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein
description	An efficient vaccine for human metapneumovirus (hMPV) will likely rely on neutralizing antibodies against the fusion protein (F). Here, the authors determine the crystal structure of pre-fusion-stabilized hMPV F and identify a dense glycan shield that affects generation of neutralizing antibodies.
format	article
author	Michael B. Battles Vicente Más Eduardo Olmedillas Olga Cano Mónica Vázquez Laura Rodríguez José A. Melero Jason S. McLellan
author_facet	Michael B. Battles Vicente Más Eduardo Olmedillas Olga Cano Mónica Vázquez Laura Rodríguez José A. Melero Jason S. McLellan
author_sort	Michael B. Battles
title	Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein
title_short	Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein
title_full	Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein
title_fullStr	Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein
title_full_unstemmed	Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein
title_sort	structure and immunogenicity of pre-fusion-stabilized human metapneumovirus f glycoprotein
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c1c088aef2e64c7f8c8b3f48886612e5
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Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein

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