Optic Nerve Hypoplasia: A Retrospective Analysis of Clinical Presentation and Disease Severity

Audrey N Netzel,1 Robin High,2 Donny W Suh3 1Creighton University School of Medicine, Omaha, Nebraska, USA; 2University of Nebraska Medical Center College of Public Health, Omaha, Nebraska, USA; 3Children’s Hospital and Medical Center of Omaha, Omaha, Nebraska, USACorrespondence: Donny W S...

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Autores principales:	Netzel AN, High R, Suh DW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	optic nerve hypoplasia optical coherence tomography retinal nerve fiber layer thickness Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c1c1825f4b15426ca02e696f6f5daca5
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spelling	oai:doaj.org-article:c1c1825f4b15426ca02e696f6f5daca52021-12-02T04:31:10ZOptic Nerve Hypoplasia: A Retrospective Analysis of Clinical Presentation and Disease Severity1177-5483https://doaj.org/article/c1c1825f4b15426ca02e696f6f5daca52019-12-01T00:00:00Zhttps://www.dovepress.com/optic-nerve-hypoplasia-a-retrospective-analysis-of-clinical-presentati-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Audrey N Netzel,1 Robin High,2 Donny W Suh3 1Creighton University School of Medicine, Omaha, Nebraska, USA; 2University of Nebraska Medical Center College of Public Health, Omaha, Nebraska, USA; 3Children’s Hospital and Medical Center of Omaha, Omaha, Nebraska, USACorrespondence: Donny W SuhChildren’s Hospital and Medical Center of Omaha, Omaha, Nebraska, USAEmail dsuh@childrensomaha.orgPurpose: Through the establishment of relationships between optic nerve hypoplasia (ONH), optical coherence tomography (OCT) spectralis retinal nerve fiber layer (RNFL) thickness results and clinical sequelae, this study aims to identify long-term outcomes for individuals with ONH.Methods: A retrospective review of pediatric ophthalmology patients at Children’s Hospital of Omaha from January 2000 to October 2018 was performed. All patients with ONH evaluated with Heidelberg Engineering’s OCT Spectralis were identified. Patient records were investigated for visual acuity, presence of nystagmus, strabismus, and endocrinopathies. Statistical analysis with linear regression models, random intercepts models, and odds ratios were used to define relationships between RNFL thickness at the optic nerve head, nystagmus, strabismus, and endocrine dysfunction.Results: There exists a strong trend of worsening visual acuity as RNFL thickness at the optic nerve head decreases in all scanned regions. This is strongest at the temporal-superior (p=0.009) and nasal-inferior (p=0.006) regions in patients with bilateral ONH. There is insufficient evidence of a difference in prevalence of nystagmus or strabismus between subjects with unilateral or bilateral ONH. Endocrinopathy is present in 21.6% of the subjects, with no statistical difference in the type of endocrinopathy or laterality of ONH.Conclusion: Trends established indicate that best-corrected visual acuity is related to RNFL thickness at the optic nerve head. Odds ratios for the prevalence of nystagmus also point to RNFL thickness as a contributing factor. These trends may have the potential to characterize ONH severity by objective measurement of clinical outcomes and RNFL thickness at the optic nerve head.Keywords: optic nerve hypoplasia, optical coherence tomography, retinal nerve fiber layer thicknessNetzel ANHigh RSuh DWDove Medical Pressarticleoptic nerve hypoplasiaoptical coherence tomographyretinal nerve fiber layer thicknessOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 2607-2616 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	optic nerve hypoplasia optical coherence tomography retinal nerve fiber layer thickness Ophthalmology RE1-994
spellingShingle	optic nerve hypoplasia optical coherence tomography retinal nerve fiber layer thickness Ophthalmology RE1-994 Netzel AN High R Suh DW Optic Nerve Hypoplasia: A Retrospective Analysis of Clinical Presentation and Disease Severity
description	Audrey N Netzel,1 Robin High,2 Donny W Suh3 1Creighton University School of Medicine, Omaha, Nebraska, USA; 2University of Nebraska Medical Center College of Public Health, Omaha, Nebraska, USA; 3Children’s Hospital and Medical Center of Omaha, Omaha, Nebraska, USACorrespondence: Donny W SuhChildren’s Hospital and Medical Center of Omaha, Omaha, Nebraska, USAEmail dsuh@childrensomaha.orgPurpose: Through the establishment of relationships between optic nerve hypoplasia (ONH), optical coherence tomography (OCT) spectralis retinal nerve fiber layer (RNFL) thickness results and clinical sequelae, this study aims to identify long-term outcomes for individuals with ONH.Methods: A retrospective review of pediatric ophthalmology patients at Children’s Hospital of Omaha from January 2000 to October 2018 was performed. All patients with ONH evaluated with Heidelberg Engineering’s OCT Spectralis were identified. Patient records were investigated for visual acuity, presence of nystagmus, strabismus, and endocrinopathies. Statistical analysis with linear regression models, random intercepts models, and odds ratios were used to define relationships between RNFL thickness at the optic nerve head, nystagmus, strabismus, and endocrine dysfunction.Results: There exists a strong trend of worsening visual acuity as RNFL thickness at the optic nerve head decreases in all scanned regions. This is strongest at the temporal-superior (p=0.009) and nasal-inferior (p=0.006) regions in patients with bilateral ONH. There is insufficient evidence of a difference in prevalence of nystagmus or strabismus between subjects with unilateral or bilateral ONH. Endocrinopathy is present in 21.6% of the subjects, with no statistical difference in the type of endocrinopathy or laterality of ONH.Conclusion: Trends established indicate that best-corrected visual acuity is related to RNFL thickness at the optic nerve head. Odds ratios for the prevalence of nystagmus also point to RNFL thickness as a contributing factor. These trends may have the potential to characterize ONH severity by objective measurement of clinical outcomes and RNFL thickness at the optic nerve head.Keywords: optic nerve hypoplasia, optical coherence tomography, retinal nerve fiber layer thickness
format	article
author	Netzel AN High R Suh DW
author_facet	Netzel AN High R Suh DW
author_sort	Netzel AN
title	Optic Nerve Hypoplasia: A Retrospective Analysis of Clinical Presentation and Disease Severity
title_short	Optic Nerve Hypoplasia: A Retrospective Analysis of Clinical Presentation and Disease Severity
title_full	Optic Nerve Hypoplasia: A Retrospective Analysis of Clinical Presentation and Disease Severity
title_fullStr	Optic Nerve Hypoplasia: A Retrospective Analysis of Clinical Presentation and Disease Severity
title_full_unstemmed	Optic Nerve Hypoplasia: A Retrospective Analysis of Clinical Presentation and Disease Severity
title_sort	optic nerve hypoplasia: a retrospective analysis of clinical presentation and disease severity
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/c1c1825f4b15426ca02e696f6f5daca5
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_version_	1718401214039719936

Optic Nerve Hypoplasia: A Retrospective Analysis of Clinical Presentation and Disease Severity

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