Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model

Abstract A series of phthalimide analogues, novelized with high-valued bioactive scaffolds was synthesized by means of click-chemistry under non-conventional microwave heating and evaluated as noteworthy growth inhibitors of Plasmodium falciparum (3D7 and W2) in culture. Analogues 6a, 6h and 6 u sho...

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Autores principales: Prashant Kumar, Angela O. Achieng, Vinoth Rajendran, Prahlad C. Ghosh, Brajendra K. Singh, Manmeet Rawat, Douglas J. Perkins, Prakasha Kempaiah, Brijesh Rathi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c1c71899bdf946b8987fa7373bc03d37
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