Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets

Aryl azoles are common scaffolds in pharmaceutically relevant molecules. Here, the authors report the mild and highly regioselective ortho magnesiation of aryl azoles using a tailored magnesium amide base in hydrocarbon solvents followed by an efficient Pd-catalyzed arylation.

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Autores principales:	Ferdinand H. Lutter, Lucie Grokenberger, Luca Alessandro Perego, Diego Broggini, Sébastien Lemaire, Simon Wagschal, Paul Knochel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1c7da05e71b426d8d98fbff31589ad0
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spelling	oai:doaj.org-article:c1c7da05e71b426d8d98fbff31589ad02021-12-02T19:12:28ZRegioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets10.1038/s41467-020-18188-z2041-1723https://doaj.org/article/c1c7da05e71b426d8d98fbff31589ad02020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18188-zhttps://doaj.org/toc/2041-1723Aryl azoles are common scaffolds in pharmaceutically relevant molecules. Here, the authors report the mild and highly regioselective ortho magnesiation of aryl azoles using a tailored magnesium amide base in hydrocarbon solvents followed by an efficient Pd-catalyzed arylation.Ferdinand H. LutterLucie GrokenbergerLuca Alessandro PeregoDiego BrogginiSébastien LemaireSimon WagschalPaul KnochelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ferdinand H. Lutter Lucie Grokenberger Luca Alessandro Perego Diego Broggini Sébastien Lemaire Simon Wagschal Paul Knochel Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets
description	Aryl azoles are common scaffolds in pharmaceutically relevant molecules. Here, the authors report the mild and highly regioselective ortho magnesiation of aryl azoles using a tailored magnesium amide base in hydrocarbon solvents followed by an efficient Pd-catalyzed arylation.
format	article
author	Ferdinand H. Lutter Lucie Grokenberger Luca Alessandro Perego Diego Broggini Sébastien Lemaire Simon Wagschal Paul Knochel
author_facet	Ferdinand H. Lutter Lucie Grokenberger Luca Alessandro Perego Diego Broggini Sébastien Lemaire Simon Wagschal Paul Knochel
author_sort	Ferdinand H. Lutter
title	Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets
title_short	Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets
title_full	Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets
title_fullStr	Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets
title_full_unstemmed	Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets
title_sort	regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c1c7da05e71b426d8d98fbff31589ad0
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Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets

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