Hypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer’s Disease

Neurodegenerative diseases (NDs) like Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, and Huntington’s disease predominantly pose a significant socioeconomic burden. Characterized by progressive neural dysfunction coupled with motor or intellectual impair...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Oluyomi Stephen Adeyemi, Oluwakemi Josephine Awakan, Lawrence Boluwatife Afolabi, Damilare Emmanuel Rotimi, Elizabeth Oluwayemi, Chiagoziem A. Otuechere, Omodele Ibraheem, Tobiloba Chritiana Elebiyo, Omokolade Alejolowo, Afolake T. Arowolo
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/c1cf4590be2d48c6bd94bdd8bb314c39
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c1cf4590be2d48c6bd94bdd8bb314c39
record_format	dspace
spelling	oai:doaj.org-article:c1cf4590be2d48c6bd94bdd8bb314c392021-11-22T01:10:57ZHypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer’s Disease1942-099410.1155/2021/5522981https://doaj.org/article/c1cf4590be2d48c6bd94bdd8bb314c392021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5522981https://doaj.org/toc/1942-0994Neurodegenerative diseases (NDs) like Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, and Huntington’s disease predominantly pose a significant socioeconomic burden. Characterized by progressive neural dysfunction coupled with motor or intellectual impairment, the pathogenesis of ND may result from contributions of certain environmental and molecular factors. One such condition is hypoxia, characterized by reduced organ/tissue exposure to oxygen. Reduced oxygen supply often occurs during the pathogenesis of ND and the aging process. Despite the well-established relationship between these two conditions (i.e., hypoxia and ND), the underlying molecular events or mechanisms connecting hypoxia to ND remain ill-defined. However, the relatedness may stem from the protective or deleterious effects of the transcription factor, hypoxia-inducible factor 1-alpha (HIF-1α). The upregulation of HIF-1α occurs in the pathogenesis of most NDs. The dual function of HIF-1α in acting as a “killer factor” or a “protective factor” depends on the prevailing local cellular condition. The kynurenine pathway is a metabolic pathway involved in the oxidative breakdown of tryptophan. It is essential in neurotransmission and immune function and, like hypoxia, associated with ND. Thus, a good understanding of factors, including hypoxia (i.e., the biochemical implication of HIF-1α) and kynurenine pathway activation in NDs, focusing on Alzheimer’s disease could prove beneficial to new therapeutic approaches for this disease, thus the aim of this review.Oluyomi Stephen AdeyemiOluwakemi Josephine AwakanLawrence Boluwatife AfolabiDamilare Emmanuel RotimiElizabeth OluwayemiChiagoziem A. OtuechereOmodele IbraheemTobiloba Chritiana ElebiyoOmokolade AlejolowoAfolake T. ArowoloHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Oluyomi Stephen Adeyemi Oluwakemi Josephine Awakan Lawrence Boluwatife Afolabi Damilare Emmanuel Rotimi Elizabeth Oluwayemi Chiagoziem A. Otuechere Omodele Ibraheem Tobiloba Chritiana Elebiyo Omokolade Alejolowo Afolake T. Arowolo Hypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer’s Disease
description	Neurodegenerative diseases (NDs) like Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, and Huntington’s disease predominantly pose a significant socioeconomic burden. Characterized by progressive neural dysfunction coupled with motor or intellectual impairment, the pathogenesis of ND may result from contributions of certain environmental and molecular factors. One such condition is hypoxia, characterized by reduced organ/tissue exposure to oxygen. Reduced oxygen supply often occurs during the pathogenesis of ND and the aging process. Despite the well-established relationship between these two conditions (i.e., hypoxia and ND), the underlying molecular events or mechanisms connecting hypoxia to ND remain ill-defined. However, the relatedness may stem from the protective or deleterious effects of the transcription factor, hypoxia-inducible factor 1-alpha (HIF-1α). The upregulation of HIF-1α occurs in the pathogenesis of most NDs. The dual function of HIF-1α in acting as a “killer factor” or a “protective factor” depends on the prevailing local cellular condition. The kynurenine pathway is a metabolic pathway involved in the oxidative breakdown of tryptophan. It is essential in neurotransmission and immune function and, like hypoxia, associated with ND. Thus, a good understanding of factors, including hypoxia (i.e., the biochemical implication of HIF-1α) and kynurenine pathway activation in NDs, focusing on Alzheimer’s disease could prove beneficial to new therapeutic approaches for this disease, thus the aim of this review.
format	article
author	Oluyomi Stephen Adeyemi Oluwakemi Josephine Awakan Lawrence Boluwatife Afolabi Damilare Emmanuel Rotimi Elizabeth Oluwayemi Chiagoziem A. Otuechere Omodele Ibraheem Tobiloba Chritiana Elebiyo Omokolade Alejolowo Afolake T. Arowolo
author_facet	Oluyomi Stephen Adeyemi Oluwakemi Josephine Awakan Lawrence Boluwatife Afolabi Damilare Emmanuel Rotimi Elizabeth Oluwayemi Chiagoziem A. Otuechere Omodele Ibraheem Tobiloba Chritiana Elebiyo Omokolade Alejolowo Afolake T. Arowolo
author_sort	Oluyomi Stephen Adeyemi
title	Hypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer’s Disease
title_short	Hypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer’s Disease
title_full	Hypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer’s Disease
title_fullStr	Hypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer’s Disease
title_full_unstemmed	Hypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer’s Disease
title_sort	hypoxia and the kynurenine pathway: implications and therapeutic prospects in alzheimer’s disease
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/c1cf4590be2d48c6bd94bdd8bb314c39
work_keys_str_mv	AT oluyomistephenadeyemi hypoxiaandthekynureninepathwayimplicationsandtherapeuticprospectsinalzheimersdisease AT oluwakemijosephineawakan hypoxiaandthekynureninepathwayimplicationsandtherapeuticprospectsinalzheimersdisease AT lawrenceboluwatifeafolabi hypoxiaandthekynureninepathwayimplicationsandtherapeuticprospectsinalzheimersdisease AT damilareemmanuelrotimi hypoxiaandthekynureninepathwayimplicationsandtherapeuticprospectsinalzheimersdisease AT elizabetholuwayemi hypoxiaandthekynureninepathwayimplicationsandtherapeuticprospectsinalzheimersdisease AT chiagoziemaotuechere hypoxiaandthekynureninepathwayimplicationsandtherapeuticprospectsinalzheimersdisease AT omodeleibraheem hypoxiaandthekynureninepathwayimplicationsandtherapeuticprospectsinalzheimersdisease AT tobilobachritianaelebiyo hypoxiaandthekynureninepathwayimplicationsandtherapeuticprospectsinalzheimersdisease AT omokoladealejolowo hypoxiaandthekynureninepathwayimplicationsandtherapeuticprospectsinalzheimersdisease AT afolaketarowolo hypoxiaandthekynureninepathwayimplicationsandtherapeuticprospectsinalzheimersdisease
_version_	1718418366946869248

Hypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer’s Disease

Ejemplares similares