Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.

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Autores principales:	Charis E. Teh, Najoua Lalaoui, Reema Jain, Antonia N. Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M. Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A. O’Reilly, Dale I. Godfrey, Gordon K. Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, Daniel H. D. Gray
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1d02d8f3cfd4e61aaa53ba2e9e08e3d
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spelling	oai:doaj.org-article:c1d02d8f3cfd4e61aaa53ba2e9e08e3d2021-12-02T16:49:41ZLinear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis10.1038/ncomms133532041-1723https://doaj.org/article/c1d02d8f3cfd4e61aaa53ba2e9e08e3d2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13353https://doaj.org/toc/2041-1723LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.Charis E. TehNajoua LalaouiReema JainAntonia N. PolicheniMelanie HeinleinSilvia Alvarez-DiazJulie M. SheridanEva RieserStefanie DeuserMaurice DardingHui-Fern KoayYifang HuFiona KupresaninLorraine A. O’ReillyDale I. GodfreyGordon K. SmythPhilippe BouilletAndreas StrasserHenning WalczakJohn SilkeDaniel H. D. GrayNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Charis E. Teh Najoua Lalaoui Reema Jain Antonia N. Policheni Melanie Heinlein Silvia Alvarez-Diaz Julie M. Sheridan Eva Rieser Stefanie Deuser Maurice Darding Hui-Fern Koay Yifang Hu Fiona Kupresanin Lorraine A. O’Reilly Dale I. Godfrey Gordon K. Smyth Philippe Bouillet Andreas Strasser Henning Walczak John Silke Daniel H. D. Gray Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis
description	LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.
format	article
author	Charis E. Teh Najoua Lalaoui Reema Jain Antonia N. Policheni Melanie Heinlein Silvia Alvarez-Diaz Julie M. Sheridan Eva Rieser Stefanie Deuser Maurice Darding Hui-Fern Koay Yifang Hu Fiona Kupresanin Lorraine A. O’Reilly Dale I. Godfrey Gordon K. Smyth Philippe Bouillet Andreas Strasser Henning Walczak John Silke Daniel H. D. Gray
author_facet	Charis E. Teh Najoua Lalaoui Reema Jain Antonia N. Policheni Melanie Heinlein Silvia Alvarez-Diaz Julie M. Sheridan Eva Rieser Stefanie Deuser Maurice Darding Hui-Fern Koay Yifang Hu Fiona Kupresanin Lorraine A. O’Reilly Dale I. Godfrey Gordon K. Smyth Philippe Bouillet Andreas Strasser Henning Walczak John Silke Daniel H. D. Gray
author_sort	Charis E. Teh
title	Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis
title_short	Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis
title_full	Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis
title_fullStr	Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis
title_full_unstemmed	Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis
title_sort	linear ubiquitin chain assembly complex coordinates late thymic t-cell differentiation and regulatory t-cell homeostasis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c1d02d8f3cfd4e61aaa53ba2e9e08e3d
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Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

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