What’s “up”? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy

This study seeks to confirm whether lesions in posterior regions of the brain involved in visuo-spatial processing are of functional relevance to the processing of words with spatial meaning. We investigated whether patients with Posterior Cortical Atrophy (PCA), an atypical form of Alzheimer’s Dise...

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Autores principales:	Zubaida Shebani, Peter J. Nestor, Friedemann Pulvermüller
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	posterior cortical atrophy PCA working memory semantic processing embodiment cognition spatial prepositions Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c1d0d15beedd47c4a997723be7fdfecf
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id	oai:doaj.org-article:c1d0d15beedd47c4a997723be7fdfecf
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spelling	oai:doaj.org-article:c1d0d15beedd47c4a997723be7fdfecf2021-12-01T21:46:58ZWhat’s “up”? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy1662-516110.3389/fnhum.2021.731104https://doaj.org/article/c1d0d15beedd47c4a997723be7fdfecf2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnhum.2021.731104/fullhttps://doaj.org/toc/1662-5161This study seeks to confirm whether lesions in posterior regions of the brain involved in visuo-spatial processing are of functional relevance to the processing of words with spatial meaning. We investigated whether patients with Posterior Cortical Atrophy (PCA), an atypical form of Alzheimer’s Disease which predominantly affects parieto-occipital brain regions, is associated with deficits in working memory for spatial prepositions. Case series of patients with PCA and matched healthy controls performed tests of immediate and delayed serial recall on words from three lexico-semantic word categories: number words (twelve), spatial prepositions (behind) and function words (e.g., shall). The three word categories were closely matched for a number of psycholinguistic and semantic variables including length, bi-/tri-gram frequency, word frequency, valence and arousal. Relative to controls, memory performance of PCA patients on short word lists was significantly impaired on spatial prepositions in the delayed serial recall task. These results suggest that lesions in posterior parieto-occipital regions specifically impair the processing of spatial prepositions. Our findings point to a pertinent role of posterior cortical regions in the semantic processing of words with spatial meaning and provide strong support for modality-specific semantic theories that recognize the necessary contributions of sensorimotor regions to conceptual semantic processing.Zubaida ShebaniZubaida ShebaniPeter J. NestorFriedemann PulvermüllerFriedemann PulvermüllerFriedemann PulvermüllerFriedemann PulvermüllerFrontiers Media S.A.articleposterior cortical atrophyPCAworking memorysemantic processingembodiment cognitionspatial prepositionsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Human Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	posterior cortical atrophy PCA working memory semantic processing embodiment cognition spatial prepositions Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	posterior cortical atrophy PCA working memory semantic processing embodiment cognition spatial prepositions Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Zubaida Shebani Zubaida Shebani Peter J. Nestor Friedemann Pulvermüller Friedemann Pulvermüller Friedemann Pulvermüller Friedemann Pulvermüller What’s “up”? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy
description	This study seeks to confirm whether lesions in posterior regions of the brain involved in visuo-spatial processing are of functional relevance to the processing of words with spatial meaning. We investigated whether patients with Posterior Cortical Atrophy (PCA), an atypical form of Alzheimer’s Disease which predominantly affects parieto-occipital brain regions, is associated with deficits in working memory for spatial prepositions. Case series of patients with PCA and matched healthy controls performed tests of immediate and delayed serial recall on words from three lexico-semantic word categories: number words (twelve), spatial prepositions (behind) and function words (e.g., shall). The three word categories were closely matched for a number of psycholinguistic and semantic variables including length, bi-/tri-gram frequency, word frequency, valence and arousal. Relative to controls, memory performance of PCA patients on short word lists was significantly impaired on spatial prepositions in the delayed serial recall task. These results suggest that lesions in posterior parieto-occipital regions specifically impair the processing of spatial prepositions. Our findings point to a pertinent role of posterior cortical regions in the semantic processing of words with spatial meaning and provide strong support for modality-specific semantic theories that recognize the necessary contributions of sensorimotor regions to conceptual semantic processing.
format	article
author	Zubaida Shebani Zubaida Shebani Peter J. Nestor Friedemann Pulvermüller Friedemann Pulvermüller Friedemann Pulvermüller Friedemann Pulvermüller
author_facet	Zubaida Shebani Zubaida Shebani Peter J. Nestor Friedemann Pulvermüller Friedemann Pulvermüller Friedemann Pulvermüller Friedemann Pulvermüller
author_sort	Zubaida Shebani
title	What’s “up”? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy
title_short	What’s “up”? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy
title_full	What’s “up”? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy
title_fullStr	What’s “up”? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy
title_full_unstemmed	What’s “up”? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy
title_sort	what’s “up”? impaired spatial preposition processing in posterior cortical atrophy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c1d0d15beedd47c4a997723be7fdfecf
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What’s “up”? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy

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