Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice

Oral mucositis is a common radiotherapy-induced complication among nasal, oral and laryngeal cancer (NOALC) patients. This complication leads to decreased quality of life and has few treatments. Here, fractionated radiation was performed to mimic radiotherapy for NOALCs in mouse models. Oral microbi...

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Autores principales:	Huiwen Xiao, Yao Fan, Yuan Li, Jiali Dong, Shuqin Zhang, Bin Wang, Jia Liu, Xingzhong Liu, Saijun Fan, Jian Guan, Ming Cui
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Nasal Oral and laryngeal cancer Radiotherapy Radiation-induced oral mucositis Oral and gut microbiota Lactobacillaceae Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/c1d8f40e4b9a482d84a15b637cda6b72
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spelling	oai:doaj.org-article:c1d8f40e4b9a482d84a15b637cda6b722021-11-04T04:28:11ZOral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice2001-037010.1016/j.csbj.2021.10.028https://doaj.org/article/c1d8f40e4b9a482d84a15b637cda6b722021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2001037021004505https://doaj.org/toc/2001-0370Oral mucositis is a common radiotherapy-induced complication among nasal, oral and laryngeal cancer (NOALC) patients. This complication leads to decreased quality of life and has few treatments. Here, fractionated radiation was performed to mimic radiotherapy for NOALCs in mouse models. Oral microbiota transplantation (OMT) mitigated oral mucositis, as judged by reconstructed epithelium and tongue papillae, fewer infiltrated leukocytes and more proliferative cells in the oral epithelium. The gut microbiota impacted oral mucositis progression, and OMT restructured oral and gut bacteria configurations and reprogrammed the gene expression profile of tongue tissues. In vivo silencing of glossal S100 calcium binding protein A9 debilitated the radioprotection of OMT. In light of clinical samples, we identified that patients with different alteration trends of Lactobacillaceae frequency presented different primary lesions and prognoses of NOALC following radiotherapy. Together, our findings provide new insights into the oral-gut microbiota axis and underpin the suggestion that OMT might be harnessed as a novel remedy to fight against oral mucositis in NOALC patients following radiotherapy in preclinical settings. Of note, oral microorganisms, such as Lactobacillaceae, might be employed as biomarkers to predict the prognosis of NOALC with radiotherapy.Huiwen XiaoYao FanYuan LiJiali DongShuqin ZhangBin WangJia LiuXingzhong LiuSaijun FanJian GuanMing CuiElsevierarticleNasalOral and laryngeal cancerRadiotherapyRadiation-induced oral mucositisOral and gut microbiotaLactobacillaceaeBiotechnologyTP248.13-248.65ENComputational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5898-5910 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nasal Oral and laryngeal cancer Radiotherapy Radiation-induced oral mucositis Oral and gut microbiota Lactobacillaceae Biotechnology TP248.13-248.65
spellingShingle	Nasal Oral and laryngeal cancer Radiotherapy Radiation-induced oral mucositis Oral and gut microbiota Lactobacillaceae Biotechnology TP248.13-248.65 Huiwen Xiao Yao Fan Yuan Li Jiali Dong Shuqin Zhang Bin Wang Jia Liu Xingzhong Liu Saijun Fan Jian Guan Ming Cui Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice
description	Oral mucositis is a common radiotherapy-induced complication among nasal, oral and laryngeal cancer (NOALC) patients. This complication leads to decreased quality of life and has few treatments. Here, fractionated radiation was performed to mimic radiotherapy for NOALCs in mouse models. Oral microbiota transplantation (OMT) mitigated oral mucositis, as judged by reconstructed epithelium and tongue papillae, fewer infiltrated leukocytes and more proliferative cells in the oral epithelium. The gut microbiota impacted oral mucositis progression, and OMT restructured oral and gut bacteria configurations and reprogrammed the gene expression profile of tongue tissues. In vivo silencing of glossal S100 calcium binding protein A9 debilitated the radioprotection of OMT. In light of clinical samples, we identified that patients with different alteration trends of Lactobacillaceae frequency presented different primary lesions and prognoses of NOALC following radiotherapy. Together, our findings provide new insights into the oral-gut microbiota axis and underpin the suggestion that OMT might be harnessed as a novel remedy to fight against oral mucositis in NOALC patients following radiotherapy in preclinical settings. Of note, oral microorganisms, such as Lactobacillaceae, might be employed as biomarkers to predict the prognosis of NOALC with radiotherapy.
format	article
author	Huiwen Xiao Yao Fan Yuan Li Jiali Dong Shuqin Zhang Bin Wang Jia Liu Xingzhong Liu Saijun Fan Jian Guan Ming Cui
author_facet	Huiwen Xiao Yao Fan Yuan Li Jiali Dong Shuqin Zhang Bin Wang Jia Liu Xingzhong Liu Saijun Fan Jian Guan Ming Cui
author_sort	Huiwen Xiao
title	Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice
title_short	Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice
title_full	Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice
title_fullStr	Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice
title_full_unstemmed	Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice
title_sort	oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c1d8f40e4b9a482d84a15b637cda6b72
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Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice

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