Behavioural effects of task-relevant neuromodulation by rTMS on giving-up

Abstract Recent studies suggest that online repetitive transcranial magnetic stimulation (rTMS) can induce local entrainment of ongoing endogenous oscillatory activity during a task. This effect may impact cognitive performance, depending on the function of the oscillation. In this study, we aimed t...

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Autores principales:	Eri Miyauchi, Masahiro Kawasaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c1da1d8f04514ede9a0e4434512ec017
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spelling	oai:doaj.org-article:c1da1d8f04514ede9a0e4434512ec0172021-11-21T12:24:27ZBehavioural effects of task-relevant neuromodulation by rTMS on giving-up10.1038/s41598-021-01645-02045-2322https://doaj.org/article/c1da1d8f04514ede9a0e4434512ec0172021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01645-0https://doaj.org/toc/2045-2322Abstract Recent studies suggest that online repetitive transcranial magnetic stimulation (rTMS) can induce local entrainment of ongoing endogenous oscillatory activity during a task. This effect may impact cognitive performance, depending on the function of the oscillation. In this study, we aimed to investigate the effects of stimulation frequency and target location that are relevant to the cognitive processes of giving-up. We first investigated the correlations between the EEG oscillations and cognitive giving-up processes during problem-solving tasks (Experiment 1). We then conducted online rTMS to examine the frequency-dependent stimulation effects of rTMS on the performance of problem-solving tasks and ongoing oscillations (Experiment 2). The results of Experiment 1 suggested that the frontal theta rhythm is associated with the giving-up processes and that the frontal alpha rhythm is associated with problem-solving behaviour. Accordingly, we hypothesised that rTMS at the theta frequency would induce ongoing theta activity and accelerate the giving-up behaviour, while rTMS at the alpha frequency would induce ongoing alpha activity and slow down the giving-up behaviour in Experiment 2. The results showed that theta-frequency rTMS application induced an increase in theta amplitudes and shortened the giving-up response. Alpha-frequency rTMS application induced an increase in alpha amplitudes, but did not change giving-up responses. Considering the close resemblance between giving-up behaviour and rumination in depression, neuromodulation of cognitive giving-up processes may lead to a new intervention to treat depression by rTMS. Furthermore, this study strengthens the hypothesis that modulating task-relevant oscillations by rTMS could induce behavioural changes related to cognitive performance.Eri MiyauchiMasahiro KawasakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eri Miyauchi Masahiro Kawasaki Behavioural effects of task-relevant neuromodulation by rTMS on giving-up
description	Abstract Recent studies suggest that online repetitive transcranial magnetic stimulation (rTMS) can induce local entrainment of ongoing endogenous oscillatory activity during a task. This effect may impact cognitive performance, depending on the function of the oscillation. In this study, we aimed to investigate the effects of stimulation frequency and target location that are relevant to the cognitive processes of giving-up. We first investigated the correlations between the EEG oscillations and cognitive giving-up processes during problem-solving tasks (Experiment 1). We then conducted online rTMS to examine the frequency-dependent stimulation effects of rTMS on the performance of problem-solving tasks and ongoing oscillations (Experiment 2). The results of Experiment 1 suggested that the frontal theta rhythm is associated with the giving-up processes and that the frontal alpha rhythm is associated with problem-solving behaviour. Accordingly, we hypothesised that rTMS at the theta frequency would induce ongoing theta activity and accelerate the giving-up behaviour, while rTMS at the alpha frequency would induce ongoing alpha activity and slow down the giving-up behaviour in Experiment 2. The results showed that theta-frequency rTMS application induced an increase in theta amplitudes and shortened the giving-up response. Alpha-frequency rTMS application induced an increase in alpha amplitudes, but did not change giving-up responses. Considering the close resemblance between giving-up behaviour and rumination in depression, neuromodulation of cognitive giving-up processes may lead to a new intervention to treat depression by rTMS. Furthermore, this study strengthens the hypothesis that modulating task-relevant oscillations by rTMS could induce behavioural changes related to cognitive performance.
format	article
author	Eri Miyauchi Masahiro Kawasaki
author_facet	Eri Miyauchi Masahiro Kawasaki
author_sort	Eri Miyauchi
title	Behavioural effects of task-relevant neuromodulation by rTMS on giving-up
title_short	Behavioural effects of task-relevant neuromodulation by rTMS on giving-up
title_full	Behavioural effects of task-relevant neuromodulation by rTMS on giving-up
title_fullStr	Behavioural effects of task-relevant neuromodulation by rTMS on giving-up
title_full_unstemmed	Behavioural effects of task-relevant neuromodulation by rTMS on giving-up
title_sort	behavioural effects of task-relevant neuromodulation by rtms on giving-up
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c1da1d8f04514ede9a0e4434512ec017
work_keys_str_mv	AT erimiyauchi behaviouraleffectsoftaskrelevantneuromodulationbyrtmsongivingup AT masahirokawasaki behaviouraleffectsoftaskrelevantneuromodulationbyrtmsongivingup
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Behavioural effects of task-relevant neuromodulation by rTMS on giving-up

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