Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation.

Vitamin D deficiency has been associated with an increased risk of developing a number of diseases. Here we investigated samples from 71 pre-diabetic individuals of the VitDmet study, a 5-month high dose vitamin D3 intervention trial during Finnish winter, for their changes in serum 25-hydroxyvitami...

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Autores principales:	Carsten Carlberg, Sabine Seuter, Vanessa D F de Mello, Ursula Schwab, Sari Voutilainen, Kari Pulkki, Tarja Nurmi, Jyrki Virtanen, Tomi-Pekka Tuomainen, Matti Uusitupa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c1da7c84d4e946b2919a4548d3f93c58
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spelling	oai:doaj.org-article:c1da7c84d4e946b2919a4548d3f93c582021-11-18T09:02:07ZPrimary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation.1932-620310.1371/journal.pone.0071042https://doaj.org/article/c1da7c84d4e946b2919a4548d3f93c582013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23923049/?tool=EBIhttps://doaj.org/toc/1932-6203Vitamin D deficiency has been associated with an increased risk of developing a number of diseases. Here we investigated samples from 71 pre-diabetic individuals of the VitDmet study, a 5-month high dose vitamin D3 intervention trial during Finnish winter, for their changes in serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations and the expression of primary vitamin D target genes in peripheral blood mononuclear cells and adipose tissue. A negative correlation between serum concentrations of parathyroid hormone and 25(OH)D3 suggested an overall normal physiological vitamin D response among the participants. The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for vitamin D signaling in both primary tissues. However, in a ranking of the samples concerning their expected response to vitamin D only the top half showed a positive correlation between the changes of CD14 or THBD mRNA and serum 25(OH)D3 concentrations. Interestingly, this categorization allows unmasking a negative correlation between changes in serum concentrations of 25(OH)D3 and the inflammation marker interleukin 6. We propose the genes CD14 and THBD as transcriptomic biomarkers, from which the effects of a vitamin D3 supplementation can be evaluated. These biomarkers allow the classification of subjects into those, who might benefit from a vitamin D3 supplementation, and others who do not.Carsten CarlbergSabine SeuterVanessa D F de MelloUrsula SchwabSari VoutilainenKari PulkkiTarja NurmiJyrki VirtanenTomi-Pekka TuomainenMatti UusitupaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e71042 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carsten Carlberg Sabine Seuter Vanessa D F de Mello Ursula Schwab Sari Voutilainen Kari Pulkki Tarja Nurmi Jyrki Virtanen Tomi-Pekka Tuomainen Matti Uusitupa Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation.
description	Vitamin D deficiency has been associated with an increased risk of developing a number of diseases. Here we investigated samples from 71 pre-diabetic individuals of the VitDmet study, a 5-month high dose vitamin D3 intervention trial during Finnish winter, for their changes in serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations and the expression of primary vitamin D target genes in peripheral blood mononuclear cells and adipose tissue. A negative correlation between serum concentrations of parathyroid hormone and 25(OH)D3 suggested an overall normal physiological vitamin D response among the participants. The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for vitamin D signaling in both primary tissues. However, in a ranking of the samples concerning their expected response to vitamin D only the top half showed a positive correlation between the changes of CD14 or THBD mRNA and serum 25(OH)D3 concentrations. Interestingly, this categorization allows unmasking a negative correlation between changes in serum concentrations of 25(OH)D3 and the inflammation marker interleukin 6. We propose the genes CD14 and THBD as transcriptomic biomarkers, from which the effects of a vitamin D3 supplementation can be evaluated. These biomarkers allow the classification of subjects into those, who might benefit from a vitamin D3 supplementation, and others who do not.
format	article
author	Carsten Carlberg Sabine Seuter Vanessa D F de Mello Ursula Schwab Sari Voutilainen Kari Pulkki Tarja Nurmi Jyrki Virtanen Tomi-Pekka Tuomainen Matti Uusitupa
author_facet	Carsten Carlberg Sabine Seuter Vanessa D F de Mello Ursula Schwab Sari Voutilainen Kari Pulkki Tarja Nurmi Jyrki Virtanen Tomi-Pekka Tuomainen Matti Uusitupa
author_sort	Carsten Carlberg
title	Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation.
title_short	Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation.
title_full	Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation.
title_fullStr	Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation.
title_full_unstemmed	Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation.
title_sort	primary vitamin d target genes allow a categorization of possible benefits of vitamin d₃ supplementation.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c1da7c84d4e946b2919a4548d3f93c58
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Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation.

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