ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.

<h4>Background</h4>The elongase of long chain fatty acids family 6 (ELOVL6) is an enzyme that specifically catalyzes the elongation of saturated and monounsaturated fatty acids with 12, 14 and 16 carbons. ELOVL6 is expressed in lipogenic tissues and it is regulated by sterol regulatory e...

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Autores principales:	Sonsoles Morcillo, Gracia María Martín-Núñez, Gemma Rojo-Martínez, María Cruz Almaraz, Eva García-Escobar, María Luisa Mansego, Griselda de Marco, Felipe J Chaves, Federico Soriguer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c1dc20b49d03419099a5e5cc863824bf
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spelling	oai:doaj.org-article:c1dc20b49d03419099a5e5cc863824bf2021-11-18T06:51:45ZELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.1932-620310.1371/journal.pone.0021198https://doaj.org/article/c1dc20b49d03419099a5e5cc863824bf2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21701577/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The elongase of long chain fatty acids family 6 (ELOVL6) is an enzyme that specifically catalyzes the elongation of saturated and monounsaturated fatty acids with 12, 14 and 16 carbons. ELOVL6 is expressed in lipogenic tissues and it is regulated by sterol regulatory element binding protein 1 (SREBP-1).<h4>Objective</h4>We investigated whether ELOVL6 genetic variation is associated with insulin sensitivity in a population from southern Spain.<h4>Design</h4>We undertook a prospective, population-based study collecting phenotypic, metabolic, nutritional and genetic information. Measurements were made of weight and height and the body mass index (BMI) was calculated. Insulin resistance was measured by homeostasis model assessment. The type of dietary fat was assessed from samples of cooking oil taken from the participants' kitchens and analyzed by gas chromatography. Five SNPs of the ELOVL6 gene were analyzed by SNPlex.<h4>Results</h4>Carriers of the minor alleles of the SNPs rs9997926 and rs6824447 had a lower risk of having high HOMA_IR, whereas carriers of the minor allele rs17041272 had a higher risk of being insulin resistant. An interaction was detected between the rs6824447 polymorphism and the intake of oil in relation with insulin resistance, such that carriers of this minor allele who consumed sunflower oil had lower HOMA_IR than those who did not have this allele (P = 0.001).<h4>Conclusions</h4>Genetic variations in the ELOVL6 gene were associated with insulin sensitivity in this population-based study.Sonsoles MorcilloGracia María Martín-NúñezGemma Rojo-MartínezMaría Cruz AlmarazEva García-EscobarMaría Luisa MansegoGriselda de MarcoFelipe J ChavesFederico SoriguerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e21198 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sonsoles Morcillo Gracia María Martín-Núñez Gemma Rojo-Martínez María Cruz Almaraz Eva García-Escobar María Luisa Mansego Griselda de Marco Felipe J Chaves Federico Soriguer ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.
description	<h4>Background</h4>The elongase of long chain fatty acids family 6 (ELOVL6) is an enzyme that specifically catalyzes the elongation of saturated and monounsaturated fatty acids with 12, 14 and 16 carbons. ELOVL6 is expressed in lipogenic tissues and it is regulated by sterol regulatory element binding protein 1 (SREBP-1).<h4>Objective</h4>We investigated whether ELOVL6 genetic variation is associated with insulin sensitivity in a population from southern Spain.<h4>Design</h4>We undertook a prospective, population-based study collecting phenotypic, metabolic, nutritional and genetic information. Measurements were made of weight and height and the body mass index (BMI) was calculated. Insulin resistance was measured by homeostasis model assessment. The type of dietary fat was assessed from samples of cooking oil taken from the participants' kitchens and analyzed by gas chromatography. Five SNPs of the ELOVL6 gene were analyzed by SNPlex.<h4>Results</h4>Carriers of the minor alleles of the SNPs rs9997926 and rs6824447 had a lower risk of having high HOMA_IR, whereas carriers of the minor allele rs17041272 had a higher risk of being insulin resistant. An interaction was detected between the rs6824447 polymorphism and the intake of oil in relation with insulin resistance, such that carriers of this minor allele who consumed sunflower oil had lower HOMA_IR than those who did not have this allele (P = 0.001).<h4>Conclusions</h4>Genetic variations in the ELOVL6 gene were associated with insulin sensitivity in this population-based study.
format	article
author	Sonsoles Morcillo Gracia María Martín-Núñez Gemma Rojo-Martínez María Cruz Almaraz Eva García-Escobar María Luisa Mansego Griselda de Marco Felipe J Chaves Federico Soriguer
author_facet	Sonsoles Morcillo Gracia María Martín-Núñez Gemma Rojo-Martínez María Cruz Almaraz Eva García-Escobar María Luisa Mansego Griselda de Marco Felipe J Chaves Federico Soriguer
author_sort	Sonsoles Morcillo
title	ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.
title_short	ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.
title_full	ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.
title_fullStr	ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.
title_full_unstemmed	ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.
title_sort	elovl6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/c1dc20b49d03419099a5e5cc863824bf
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ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.

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