The effect of different concentrations of Saccharin on Morphine analgesia in mice with Formalin test

Objective: This study was done to investigate the relative role of sweetness and comparative effects of different taste sensation of non-caloric sweetener, saccharin, on pain and morphine antinociception by Formalin-test in mice. Methods: The Formalin-test was chosen because it measures the response...

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Autores principales:	S Nikfar, L Habibi, M Abdollahi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 1999
Materias:	morphine analgesia formalin test saccharin Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c1e407d945ee43f8b15ae56965d704aa
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spelling	oai:doaj.org-article:c1e407d945ee43f8b15ae56965d704aa2021-11-10T09:24:17ZThe effect of different concentrations of Saccharin on Morphine analgesia in mice with Formalin test1561-41072251-7170https://doaj.org/article/c1e407d945ee43f8b15ae56965d704aa1999-04-01T00:00:00Zhttp://jbums.org/article-1-2955-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: This study was done to investigate the relative role of sweetness and comparative effects of different taste sensation of non-caloric sweetener, saccharin, on pain and morphine antinociception by Formalin-test in mice. Methods: The Formalin-test was chosen because it measures the response to a long-lasting nociceptive stimulus and thus may closely resemble clinical pain. Findings: Twelve day pretreatment of animals with saccharin (0.04%, 0.08%, 0.16%) potentiated the low dose (1.5 mg/kg) of morphine-induced analgesia in early phase significantly but their effects diminished by increasing the concentration of morphine. Also in the early phase of the antinociception recording, all doses of saccharin antagonized the effect of morphine (3 mg/kg) dose-dependently and the effect of high doses of morphine (6-9 mg/kg) was antagonized by dose of saccharin (0.04%) but the effect of morphine (6 mg/kg) potentiated with high concentrations of saccharine (0.08% and 0.16%). All doses of saccharine decreased morphine analgesic effect at a dose of 9 mg/kg. Analgesic effects of low doses of morphine (1.5-3 mg/kg) were decreased by all doses of saccharine in late phase. Different concentrations of saccharin also affected the antagonistic effect of naloxone (0.4 mg/kg) on morphine-induced analgesia in both phases in Formalin-test. The high dose of saccharin (0.16%) potentiated the effect of naloxone in late phase. Conclusion: The obtained results support that hedonic is an important factor in morphine analgesia. Moreover, it seems important to consider sweet taste sensation. It is therefore inappropriate to use different concentrations of sweet saccharin solutions interchangeably.S NikfarL HabibiM AbdollahiBabol University of Medical Sciencesarticlemorphine analgesiaformalin testsaccharinMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 1, Iss 2, Pp 17-23 (1999)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	morphine analgesia formalin test saccharin Medicine R Medicine (General) R5-920
spellingShingle	morphine analgesia formalin test saccharin Medicine R Medicine (General) R5-920 S Nikfar L Habibi M Abdollahi The effect of different concentrations of Saccharin on Morphine analgesia in mice with Formalin test
description	Objective: This study was done to investigate the relative role of sweetness and comparative effects of different taste sensation of non-caloric sweetener, saccharin, on pain and morphine antinociception by Formalin-test in mice. Methods: The Formalin-test was chosen because it measures the response to a long-lasting nociceptive stimulus and thus may closely resemble clinical pain. Findings: Twelve day pretreatment of animals with saccharin (0.04%, 0.08%, 0.16%) potentiated the low dose (1.5 mg/kg) of morphine-induced analgesia in early phase significantly but their effects diminished by increasing the concentration of morphine. Also in the early phase of the antinociception recording, all doses of saccharin antagonized the effect of morphine (3 mg/kg) dose-dependently and the effect of high doses of morphine (6-9 mg/kg) was antagonized by dose of saccharin (0.04%) but the effect of morphine (6 mg/kg) potentiated with high concentrations of saccharine (0.08% and 0.16%). All doses of saccharine decreased morphine analgesic effect at a dose of 9 mg/kg. Analgesic effects of low doses of morphine (1.5-3 mg/kg) were decreased by all doses of saccharine in late phase. Different concentrations of saccharin also affected the antagonistic effect of naloxone (0.4 mg/kg) on morphine-induced analgesia in both phases in Formalin-test. The high dose of saccharin (0.16%) potentiated the effect of naloxone in late phase. Conclusion: The obtained results support that hedonic is an important factor in morphine analgesia. Moreover, it seems important to consider sweet taste sensation. It is therefore inappropriate to use different concentrations of sweet saccharin solutions interchangeably.
format	article
author	S Nikfar L Habibi M Abdollahi
author_facet	S Nikfar L Habibi M Abdollahi
author_sort	S Nikfar
title	The effect of different concentrations of Saccharin on Morphine analgesia in mice with Formalin test
title_short	The effect of different concentrations of Saccharin on Morphine analgesia in mice with Formalin test
title_full	The effect of different concentrations of Saccharin on Morphine analgesia in mice with Formalin test
title_fullStr	The effect of different concentrations of Saccharin on Morphine analgesia in mice with Formalin test
title_full_unstemmed	The effect of different concentrations of Saccharin on Morphine analgesia in mice with Formalin test
title_sort	effect of different concentrations of saccharin on morphine analgesia in mice with formalin test
publisher	Babol University of Medical Sciences
publishDate	1999
url	https://doaj.org/article/c1e407d945ee43f8b15ae56965d704aa
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The effect of different concentrations of Saccharin on Morphine analgesia in mice with Formalin test

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