Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion
Cancer cells develop specific metabolic adaptations. Here, the authors show that in prostate cancer models, the ubiquitin ligase Hect9 promotes tumor growth by accelerating glucose metabolism via ubiquitination of Hexokinase 2, a central regulator of glycolysis.
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Nature Portfolio
2019
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oai:doaj.org-article:c1e48419d9bc4725802932966b49bd522021-12-02T17:01:38ZNon-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion10.1038/s41467-019-10374-y2041-1723https://doaj.org/article/c1e48419d9bc4725802932966b49bd522019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10374-yhttps://doaj.org/toc/2041-1723Cancer cells develop specific metabolic adaptations. Here, the authors show that in prostate cancer models, the ubiquitin ligase Hect9 promotes tumor growth by accelerating glucose metabolism via ubiquitination of Hexokinase 2, a central regulator of glycolysis.Hong-Jen LeeChien-Feng LiDiane RuanJiabei HeEmily D. MontalSonja LorenzGeoffrey D. GirnunChia-Hsin ChanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
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Science Q Hong-Jen Lee Chien-Feng Li Diane Ruan Jiabei He Emily D. Montal Sonja Lorenz Geoffrey D. Girnun Chia-Hsin Chan Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion |
description |
Cancer cells develop specific metabolic adaptations. Here, the authors show that in prostate cancer models, the ubiquitin ligase Hect9 promotes tumor growth by accelerating glucose metabolism via ubiquitination of Hexokinase 2, a central regulator of glycolysis. |
format |
article |
author |
Hong-Jen Lee Chien-Feng Li Diane Ruan Jiabei He Emily D. Montal Sonja Lorenz Geoffrey D. Girnun Chia-Hsin Chan |
author_facet |
Hong-Jen Lee Chien-Feng Li Diane Ruan Jiabei He Emily D. Montal Sonja Lorenz Geoffrey D. Girnun Chia-Hsin Chan |
author_sort |
Hong-Jen Lee |
title |
Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion |
title_short |
Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion |
title_full |
Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion |
title_fullStr |
Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion |
title_full_unstemmed |
Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion |
title_sort |
non-proteolytic ubiquitination of hexokinase 2 by hecth9 controls tumor metabolism and cancer stem cell expansion |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/c1e48419d9bc4725802932966b49bd52 |
work_keys_str_mv |
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