Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

Cancer cells develop specific metabolic adaptations. Here, the authors show that in prostate cancer models, the ubiquitin ligase Hect9 promotes tumor growth by accelerating glucose metabolism via ubiquitination of Hexokinase 2, a central regulator of glycolysis.

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Autores principales: Hong-Jen Lee, Chien-Feng Li, Diane Ruan, Jiabei He, Emily D. Montal, Sonja Lorenz, Geoffrey D. Girnun, Chia-Hsin Chan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/c1e48419d9bc4725802932966b49bd52
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spelling oai:doaj.org-article:c1e48419d9bc4725802932966b49bd522021-12-02T17:01:38ZNon-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion10.1038/s41467-019-10374-y2041-1723https://doaj.org/article/c1e48419d9bc4725802932966b49bd522019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10374-yhttps://doaj.org/toc/2041-1723Cancer cells develop specific metabolic adaptations. Here, the authors show that in prostate cancer models, the ubiquitin ligase Hect9 promotes tumor growth by accelerating glucose metabolism via ubiquitination of Hexokinase 2, a central regulator of glycolysis.Hong-Jen LeeChien-Feng LiDiane RuanJiabei HeEmily D. MontalSonja LorenzGeoffrey D. GirnunChia-Hsin ChanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hong-Jen Lee
Chien-Feng Li
Diane Ruan
Jiabei He
Emily D. Montal
Sonja Lorenz
Geoffrey D. Girnun
Chia-Hsin Chan
Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion
description Cancer cells develop specific metabolic adaptations. Here, the authors show that in prostate cancer models, the ubiquitin ligase Hect9 promotes tumor growth by accelerating glucose metabolism via ubiquitination of Hexokinase 2, a central regulator of glycolysis.
format article
author Hong-Jen Lee
Chien-Feng Li
Diane Ruan
Jiabei He
Emily D. Montal
Sonja Lorenz
Geoffrey D. Girnun
Chia-Hsin Chan
author_facet Hong-Jen Lee
Chien-Feng Li
Diane Ruan
Jiabei He
Emily D. Montal
Sonja Lorenz
Geoffrey D. Girnun
Chia-Hsin Chan
author_sort Hong-Jen Lee
title Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion
title_short Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion
title_full Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion
title_fullStr Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion
title_full_unstemmed Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion
title_sort non-proteolytic ubiquitination of hexokinase 2 by hecth9 controls tumor metabolism and cancer stem cell expansion
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/c1e48419d9bc4725802932966b49bd52
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