Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

Cancer cells develop specific metabolic adaptations. Here, the authors show that in prostate cancer models, the ubiquitin ligase Hect9 promotes tumor growth by accelerating glucose metabolism via ubiquitination of Hexokinase 2, a central regulator of glycolysis.

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Detalles Bibliográficos
Autores principales: Hong-Jen Lee, Chien-Feng Li, Diane Ruan, Jiabei He, Emily D. Montal, Sonja Lorenz, Geoffrey D. Girnun, Chia-Hsin Chan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/c1e48419d9bc4725802932966b49bd52
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