Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition

Summary: Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC class II signaling on gut homeostasis remains enigma...

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Autores principales:	W. Zac Stephens, Jason L. Kubinak, Arevik Ghazaryan, Kaylyn M. Bauer, Rickesha Bell, Kate Buhrke, Tyson R. Chiaro, Allison M. Weis, William W. Tang, Josh K. Monts, Ray Soto, H. Atakan Ekiz, Ryan M. O’Connell, June L. Round
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	MHC class II intestinal epithelia antigen processing microbiome immunity macrophage Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c1e5d4d89cc84888a5fa9fbe24b048c9
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spelling	oai:doaj.org-article:c1e5d4d89cc84888a5fa9fbe24b048c92021-11-04T04:29:04ZEpithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition2211-124710.1016/j.celrep.2021.109916https://doaj.org/article/c1e5d4d89cc84888a5fa9fbe24b048c92021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211124721013899https://doaj.org/toc/2211-1247Summary: Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC class II signaling on gut homeostasis remains enigmatic. As IECs serve as the primary barrier between underlying host immune cells, we reasoned that IEC-intrinsic antigen presentation may play a role in responses toward the microbiota. Mice with an IEC-intrinsic deletion of MHC class II (IECΔMHC class II) are healthy but have fewer microbial-bound IgA, regulatory T cells (Tregs), and immune repertoire selection. This was associated with increased interindividual microbiota variation and altered proportions of two taxa in the ileum where MHC class II on IECs is highest. Intestinal mononuclear phagocytes (MNPs) have similar MHC class II transcription but less surface MHC class II and are capable of acquiring MHC class II from IECs. Thus, epithelial-myeloid interactions mediate development of adaptive responses to microbial antigens within the gastrointestinal tract.W. Zac StephensJason L. KubinakArevik GhazaryanKaylyn M. BauerRickesha BellKate BuhrkeTyson R. ChiaroAllison M. WeisWilliam W. TangJosh K. MontsRay SotoH. Atakan EkizRyan M. O’ConnellJune L. RoundElsevierarticleMHC class IIintestinal epitheliaantigen processingmicrobiomeimmunitymacrophageBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 5, Pp 109916- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MHC class II intestinal epithelia antigen processing microbiome immunity macrophage Biology (General) QH301-705.5
spellingShingle	MHC class II intestinal epithelia antigen processing microbiome immunity macrophage Biology (General) QH301-705.5 W. Zac Stephens Jason L. Kubinak Arevik Ghazaryan Kaylyn M. Bauer Rickesha Bell Kate Buhrke Tyson R. Chiaro Allison M. Weis William W. Tang Josh K. Monts Ray Soto H. Atakan Ekiz Ryan M. O’Connell June L. Round Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
description	Summary: Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC class II signaling on gut homeostasis remains enigmatic. As IECs serve as the primary barrier between underlying host immune cells, we reasoned that IEC-intrinsic antigen presentation may play a role in responses toward the microbiota. Mice with an IEC-intrinsic deletion of MHC class II (IECΔMHC class II) are healthy but have fewer microbial-bound IgA, regulatory T cells (Tregs), and immune repertoire selection. This was associated with increased interindividual microbiota variation and altered proportions of two taxa in the ileum where MHC class II on IECs is highest. Intestinal mononuclear phagocytes (MNPs) have similar MHC class II transcription but less surface MHC class II and are capable of acquiring MHC class II from IECs. Thus, epithelial-myeloid interactions mediate development of adaptive responses to microbial antigens within the gastrointestinal tract.
format	article
author	W. Zac Stephens Jason L. Kubinak Arevik Ghazaryan Kaylyn M. Bauer Rickesha Bell Kate Buhrke Tyson R. Chiaro Allison M. Weis William W. Tang Josh K. Monts Ray Soto H. Atakan Ekiz Ryan M. O’Connell June L. Round
author_facet	W. Zac Stephens Jason L. Kubinak Arevik Ghazaryan Kaylyn M. Bauer Rickesha Bell Kate Buhrke Tyson R. Chiaro Allison M. Weis William W. Tang Josh K. Monts Ray Soto H. Atakan Ekiz Ryan M. O’Connell June L. Round
author_sort	W. Zac Stephens
title	Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
title_short	Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
title_full	Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
title_fullStr	Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
title_full_unstemmed	Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
title_sort	epithelial-myeloid exchange of mhc class ii constrains immunity and microbiota composition
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c1e5d4d89cc84888a5fa9fbe24b048c9
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Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition

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