Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.

<h4>Background</h4>Bisphenol A (BPA) is a high production volume chemical widely used in food and drinks packaging. Associations have previously been reported between urinary BPA concentrations and heart disease, diabetes and liver enzymes in adult participants of the National Health and...

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Autores principales:	David Melzer, Neil E Rice, Ceri Lewis, William E Henley, Tamara S Galloway
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c1e6287e31b3483a84f8151ddbc27859
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spelling	oai:doaj.org-article:c1e6287e31b3483a84f8151ddbc278592021-11-25T06:26:46ZAssociation of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.1932-620310.1371/journal.pone.0008673https://doaj.org/article/c1e6287e31b3483a84f8151ddbc278592010-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20084273/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Bisphenol A (BPA) is a high production volume chemical widely used in food and drinks packaging. Associations have previously been reported between urinary BPA concentrations and heart disease, diabetes and liver enzymes in adult participants of the National Health and Nutrition Examination Survey (NHANES) 2003/04. We aimed to estimate associations between urinary BPA concentrations and health measures in NHANES 2005/06 and in data pooled across collection years.<h4>Methodology and findings</h4>A cross-sectional analysis of NHANES: subjects were n = 1455 (2003/04) and n = 1493 (2005/06) adults aged 18-74 years, representative of the general adult population of the United States. Regression models were adjusted for age, sex, race/ethnicity, education, income, smoking, BMI, waist circumference, and urinary creatinine concentration. Main outcomes were reported diagnoses of heart attack, coronary heart disease, angina and diabetes and serum liver enzyme levels. Urinary BPA concentrations in 2005/06 (geometric mean 1.79 ng/ml, 95% CI: 1.64 to 1.96) were lower than in 2003/04 (2.49 ng/ml, CI: 2.20 to 2.83, difference p-value = 0.00002). Higher BPA concentrations were associated with coronary heart disease in 2005/06 (OR per z-score increase in BPA = 1.33, 95%CI: 1.01 to 1.75, p = 0.043) and in pooled data (OR = 1.42, CI: 1.17 to 1.72, p = 0.001). Associations with diabetes did not reach significance in 2005/06, but pooled estimates remained significant (OR = 1.24, CI: 1.10 to 1.40, p = 0.001). There was no overall association with gamma glutamyl transferase concentrations, but pooled associations with alkaline phosphatase and lactate dehydrogenase remained significant.<h4>Conclusions</h4>Higher BPA exposure, reflected in higher urinary concentrations of BPA, is consistently associated with reported heart disease in the general adult population of the USA. Studies to clarify the mechanisms of these associations are urgently needed.David MelzerNeil E RiceCeri LewisWilliam E HenleyTamara S GallowayPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 1, p e8673 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David Melzer Neil E Rice Ceri Lewis William E Henley Tamara S Galloway Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.
description	<h4>Background</h4>Bisphenol A (BPA) is a high production volume chemical widely used in food and drinks packaging. Associations have previously been reported between urinary BPA concentrations and heart disease, diabetes and liver enzymes in adult participants of the National Health and Nutrition Examination Survey (NHANES) 2003/04. We aimed to estimate associations between urinary BPA concentrations and health measures in NHANES 2005/06 and in data pooled across collection years.<h4>Methodology and findings</h4>A cross-sectional analysis of NHANES: subjects were n = 1455 (2003/04) and n = 1493 (2005/06) adults aged 18-74 years, representative of the general adult population of the United States. Regression models were adjusted for age, sex, race/ethnicity, education, income, smoking, BMI, waist circumference, and urinary creatinine concentration. Main outcomes were reported diagnoses of heart attack, coronary heart disease, angina and diabetes and serum liver enzyme levels. Urinary BPA concentrations in 2005/06 (geometric mean 1.79 ng/ml, 95% CI: 1.64 to 1.96) were lower than in 2003/04 (2.49 ng/ml, CI: 2.20 to 2.83, difference p-value = 0.00002). Higher BPA concentrations were associated with coronary heart disease in 2005/06 (OR per z-score increase in BPA = 1.33, 95%CI: 1.01 to 1.75, p = 0.043) and in pooled data (OR = 1.42, CI: 1.17 to 1.72, p = 0.001). Associations with diabetes did not reach significance in 2005/06, but pooled estimates remained significant (OR = 1.24, CI: 1.10 to 1.40, p = 0.001). There was no overall association with gamma glutamyl transferase concentrations, but pooled associations with alkaline phosphatase and lactate dehydrogenase remained significant.<h4>Conclusions</h4>Higher BPA exposure, reflected in higher urinary concentrations of BPA, is consistently associated with reported heart disease in the general adult population of the USA. Studies to clarify the mechanisms of these associations are urgently needed.
format	article
author	David Melzer Neil E Rice Ceri Lewis William E Henley Tamara S Galloway
author_facet	David Melzer Neil E Rice Ceri Lewis William E Henley Tamara S Galloway
author_sort	David Melzer
title	Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.
title_short	Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.
title_full	Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.
title_fullStr	Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.
title_full_unstemmed	Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.
title_sort	association of urinary bisphenol a concentration with heart disease: evidence from nhanes 2003/06.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/c1e6287e31b3483a84f8151ddbc27859
work_keys_str_mv	AT davidmelzer associationofurinarybisphenolaconcentrationwithheartdiseaseevidencefromnhanes200306 AT neilerice associationofurinarybisphenolaconcentrationwithheartdiseaseevidencefromnhanes200306 AT cerilewis associationofurinarybisphenolaconcentrationwithheartdiseaseevidencefromnhanes200306 AT williamehenley associationofurinarybisphenolaconcentrationwithheartdiseaseevidencefromnhanes200306 AT tamarasgalloway associationofurinarybisphenolaconcentrationwithheartdiseaseevidencefromnhanes200306
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Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.

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