Outcome measures used in trials on gait rehabilitation in multiple sclerosis: A systematic literature review.

<h4>Background</h4>Multiple Sclerosis (MS) is associated with impaired gait and a growing number of clinical trials have investigated efficacy of various interventions. Choice of outcome measures is crucial in determining efficiency of interventions. However, it remains unclear whether t...

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Autores principales:	L Santisteban, M Teremetz, J Irazusta, P G Lindberg, A Rodriguez-Larrad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c1ef3223b4da46588ad51017de2a6251
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spelling	oai:doaj.org-article:c1ef3223b4da46588ad51017de2a62512021-12-02T20:13:58ZOutcome measures used in trials on gait rehabilitation in multiple sclerosis: A systematic literature review.1932-620310.1371/journal.pone.0257809https://doaj.org/article/c1ef3223b4da46588ad51017de2a62512021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257809https://doaj.org/toc/1932-6203<h4>Background</h4>Multiple Sclerosis (MS) is associated with impaired gait and a growing number of clinical trials have investigated efficacy of various interventions. Choice of outcome measures is crucial in determining efficiency of interventions. However, it remains unclear whether there is consensus on which outcome measures to use in gait intervention studies in MS.<h4>Objective</h4>We aimed to identify the commonly selected outcome measures in randomized controlled trials (RCTs) on gait rehabilitation interventions in people with MS. Additional aims were to identify which of the domains of the International Classification of Functioning, Disability and Health (ICF) are the most studied and to characterize how outcome measures are combined and adapted to MS severity.<h4>Methods</h4>Pubmed, Cochrane Central, Embase and Scopus databases were searched for RCT studies on gait interventions in people living with MS according to PRISMA guidelines.<h4>Results</h4>In 46 RCTs, we identified 69 different outcome measures. The most used outcome measures were 6-minute walking test and the Timed Up and Go test, used in 37% of the analyzed studies. They were followed by gait spatiotemporal parameters (35%) most often used to inform on gait speed, cadence, and step length. Fatigue was measured in 39% of studies. Participation was assessed in 50% of studies, albeit with a wide variety of scales. Only 39% of studies included measures covering all ICF levels, and Participation measures were rarely combined with gait spatiotemporal parameters (only two studies).<h4>Conclusions</h4>Selection of outcome measures remains heterogenous in RCTs on gait rehabilitation interventions in MS. However, there is a growing consensus on the need for quantitative gait spatiotemporal parameter measures combined with clinical assessments of gait, balance, and mobility in RCTs on gait interventions in MS. Future RCTs should incorporate measures of fatigue and measures from Participation domain of ICF to provide comprehensive evaluation of trial efficacy across all levels of functioning.L SantistebanM TeremetzJ IrazustaP G LindbergA Rodriguez-LarradPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257809 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q L Santisteban M Teremetz J Irazusta P G Lindberg A Rodriguez-Larrad Outcome measures used in trials on gait rehabilitation in multiple sclerosis: A systematic literature review.
description	<h4>Background</h4>Multiple Sclerosis (MS) is associated with impaired gait and a growing number of clinical trials have investigated efficacy of various interventions. Choice of outcome measures is crucial in determining efficiency of interventions. However, it remains unclear whether there is consensus on which outcome measures to use in gait intervention studies in MS.<h4>Objective</h4>We aimed to identify the commonly selected outcome measures in randomized controlled trials (RCTs) on gait rehabilitation interventions in people with MS. Additional aims were to identify which of the domains of the International Classification of Functioning, Disability and Health (ICF) are the most studied and to characterize how outcome measures are combined and adapted to MS severity.<h4>Methods</h4>Pubmed, Cochrane Central, Embase and Scopus databases were searched for RCT studies on gait interventions in people living with MS according to PRISMA guidelines.<h4>Results</h4>In 46 RCTs, we identified 69 different outcome measures. The most used outcome measures were 6-minute walking test and the Timed Up and Go test, used in 37% of the analyzed studies. They were followed by gait spatiotemporal parameters (35%) most often used to inform on gait speed, cadence, and step length. Fatigue was measured in 39% of studies. Participation was assessed in 50% of studies, albeit with a wide variety of scales. Only 39% of studies included measures covering all ICF levels, and Participation measures were rarely combined with gait spatiotemporal parameters (only two studies).<h4>Conclusions</h4>Selection of outcome measures remains heterogenous in RCTs on gait rehabilitation interventions in MS. However, there is a growing consensus on the need for quantitative gait spatiotemporal parameter measures combined with clinical assessments of gait, balance, and mobility in RCTs on gait interventions in MS. Future RCTs should incorporate measures of fatigue and measures from Participation domain of ICF to provide comprehensive evaluation of trial efficacy across all levels of functioning.
format	article
author	L Santisteban M Teremetz J Irazusta P G Lindberg A Rodriguez-Larrad
author_facet	L Santisteban M Teremetz J Irazusta P G Lindberg A Rodriguez-Larrad
author_sort	L Santisteban
title	Outcome measures used in trials on gait rehabilitation in multiple sclerosis: A systematic literature review.
title_short	Outcome measures used in trials on gait rehabilitation in multiple sclerosis: A systematic literature review.
title_full	Outcome measures used in trials on gait rehabilitation in multiple sclerosis: A systematic literature review.
title_fullStr	Outcome measures used in trials on gait rehabilitation in multiple sclerosis: A systematic literature review.
title_full_unstemmed	Outcome measures used in trials on gait rehabilitation in multiple sclerosis: A systematic literature review.
title_sort	outcome measures used in trials on gait rehabilitation in multiple sclerosis: a systematic literature review.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c1ef3223b4da46588ad51017de2a6251
work_keys_str_mv	AT lsantisteban outcomemeasuresusedintrialsongaitrehabilitationinmultiplesclerosisasystematicliteraturereview AT mteremetz outcomemeasuresusedintrialsongaitrehabilitationinmultiplesclerosisasystematicliteraturereview AT jirazusta outcomemeasuresusedintrialsongaitrehabilitationinmultiplesclerosisasystematicliteraturereview AT pglindberg outcomemeasuresusedintrialsongaitrehabilitationinmultiplesclerosisasystematicliteraturereview AT arodriguezlarrad outcomemeasuresusedintrialsongaitrehabilitationinmultiplesclerosisasystematicliteraturereview
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Outcome measures used in trials on gait rehabilitation in multiple sclerosis: A systematic literature review.

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