EFFICACY AND SAFETY OF DULOXETINE IN THE TREATMENT OF CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS

Background: One of the adverse effects of chemotherapy in the neurological field is chemotherapy-induced peripheral neuropathy (CIPN), it was an adverse effect caused by many chemotherapeutic regimens and a major cause of continuous pain in patients who survived cancer. When the symptoms get worse,...

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Autores principales:	I Putu Eka Widyadharma, Chiquita Putri Vania Rau, Rizaldy Taslim Pinzon, Yudiyanta Y, Agung Wiwiek Indrayani, Thomas Eko Purwata, Boya Nugraha
Formato:	article
Lenguaje:	EN ID
Publicado:	University of Brawijaya 2021
Materias:	pain. neuropathic pain chemotherapy induced peripheral neuropathy cancer duloxetine. Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c1efba62b6994e89bbc17b3d3d0f0098
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spelling	oai:doaj.org-article:c1efba62b6994e89bbc17b3d3d0f00982021-11-23T03:45:06ZEFFICACY AND SAFETY OF DULOXETINE IN THE TREATMENT OF CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS10.21776/ub.mnj.2021.007.01.102407-67242442-5001https://doaj.org/article/c1efba62b6994e89bbc17b3d3d0f00982021-01-01T00:00:00Zhttps://mnj.ub.ac.id/index.php/mnj/article/view/436https://doaj.org/toc/2407-6724https://doaj.org/toc/2442-5001Background: One of the adverse effects of chemotherapy in the neurological field is chemotherapy-induced peripheral neuropathy (CIPN), it was an adverse effect caused by many chemotherapeutic regimens and a major cause of continuous pain in patients who survived cancer. When the symptoms get worse, survivor’s quality of life is declining and they are often having problems with mental health, insomnia, cognitive functioning, fatigue, physical functioning, and pain. So far the choice of therapy for CIPN is still limited. Now, there was no drug approved to treat pain due to CIPN. Duloxetine are a SNRI (serotonin norepinephrine reuptake inhibitor), which it’s useful in CIPN are highly supported by evidence. Methods: We conducted a systemactic-computer based literature search on January 4, 2019 in PubMed database for article published between 2013 and 2018. We searched for a literature related with used a duloxetine for management of chemotherapy induced peripheral neuropathy. Results: From the 4 studies that included in this review, the total participants are 478 patients with neuropathic pain and already get a chemotherapy regiment. From the meta-analysis showed one study had no effect, two studies had small effect, and one study had medium effect. Conclusion: Duloxetine is a great option for the treatment of CIPN in especially reducing neuropathic pain. I Putu Eka WidyadharmaChiquita Putri Vania RauRizaldy Taslim PinzonYudiyanta YAgung Wiwiek IndrayaniThomas Eko PurwataBoya NugrahaUniversity of Brawijayaarticlepain. neuropathic painchemotherapy induced peripheral neuropathycancerduloxetine.MedicineRNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENIDMalang Neurology Journal, Vol 7, Iss 1, Pp 48-55 (2021)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	pain. neuropathic pain chemotherapy induced peripheral neuropathy cancer duloxetine. Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	pain. neuropathic pain chemotherapy induced peripheral neuropathy cancer duloxetine. Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 I Putu Eka Widyadharma Chiquita Putri Vania Rau Rizaldy Taslim Pinzon Yudiyanta Y Agung Wiwiek Indrayani Thomas Eko Purwata Boya Nugraha EFFICACY AND SAFETY OF DULOXETINE IN THE TREATMENT OF CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS
description	Background: One of the adverse effects of chemotherapy in the neurological field is chemotherapy-induced peripheral neuropathy (CIPN), it was an adverse effect caused by many chemotherapeutic regimens and a major cause of continuous pain in patients who survived cancer. When the symptoms get worse, survivor’s quality of life is declining and they are often having problems with mental health, insomnia, cognitive functioning, fatigue, physical functioning, and pain. So far the choice of therapy for CIPN is still limited. Now, there was no drug approved to treat pain due to CIPN. Duloxetine are a SNRI (serotonin norepinephrine reuptake inhibitor), which it’s useful in CIPN are highly supported by evidence. Methods: We conducted a systemactic-computer based literature search on January 4, 2019 in PubMed database for article published between 2013 and 2018. We searched for a literature related with used a duloxetine for management of chemotherapy induced peripheral neuropathy. Results: From the 4 studies that included in this review, the total participants are 478 patients with neuropathic pain and already get a chemotherapy regiment. From the meta-analysis showed one study had no effect, two studies had small effect, and one study had medium effect. Conclusion: Duloxetine is a great option for the treatment of CIPN in especially reducing neuropathic pain.
format	article
author	I Putu Eka Widyadharma Chiquita Putri Vania Rau Rizaldy Taslim Pinzon Yudiyanta Y Agung Wiwiek Indrayani Thomas Eko Purwata Boya Nugraha
author_facet	I Putu Eka Widyadharma Chiquita Putri Vania Rau Rizaldy Taslim Pinzon Yudiyanta Y Agung Wiwiek Indrayani Thomas Eko Purwata Boya Nugraha
author_sort	I Putu Eka Widyadharma
title	EFFICACY AND SAFETY OF DULOXETINE IN THE TREATMENT OF CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS
title_short	EFFICACY AND SAFETY OF DULOXETINE IN THE TREATMENT OF CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS
title_full	EFFICACY AND SAFETY OF DULOXETINE IN THE TREATMENT OF CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS
title_fullStr	EFFICACY AND SAFETY OF DULOXETINE IN THE TREATMENT OF CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS
title_full_unstemmed	EFFICACY AND SAFETY OF DULOXETINE IN THE TREATMENT OF CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS
title_sort	efficacy and safety of duloxetine in the treatment of chemotherapy induced peripheral neuropathy: a systematic review and meta-analysis
publisher	University of Brawijaya
publishDate	2021
url	https://doaj.org/article/c1efba62b6994e89bbc17b3d3d0f0098
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_version_	1718417344713195520

EFFICACY AND SAFETY OF DULOXETINE IN THE TREATMENT OF CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS

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