Modulating intrinsic connectivity: adjacent subregions within supplementary motor cortex, dorsolateral prefrontal cortex, and parietal cortex connect to separate functional networks during task and also connect during rest.

Supplementary motor area (SMA), the inferior frontal junction (IFJ), superior frontal junction (SFJ) and parietal cortex are active in many cognitive tasks. In a previous study, we found that subregions of each of these major areas were differentially active in component processes of executive funct...

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Autores principales:	Jennifer K Roth, Marcia K Johnson, Fuyuze Tokoglu, Isabella Murphy, R Todd Constable
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c1f29e9ecf7547a89fc77d3af190df23
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spelling	oai:doaj.org-article:c1f29e9ecf7547a89fc77d3af190df232021-11-18T08:27:47ZModulating intrinsic connectivity: adjacent subregions within supplementary motor cortex, dorsolateral prefrontal cortex, and parietal cortex connect to separate functional networks during task and also connect during rest.1932-620310.1371/journal.pone.0090672https://doaj.org/article/c1f29e9ecf7547a89fc77d3af190df232014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24637793/?tool=EBIhttps://doaj.org/toc/1932-6203Supplementary motor area (SMA), the inferior frontal junction (IFJ), superior frontal junction (SFJ) and parietal cortex are active in many cognitive tasks. In a previous study, we found that subregions of each of these major areas were differentially active in component processes of executive function during working memory tasks. In the present study, each of these subregions was used as a seed in a whole brain functional connectivity analysis of working memory and resting state data. These regions show functional connectivity to different networks, thus supporting the parcellation of these major regions into functional subregions. Many regions showing significant connectivity during the working memory residual data (with task events regressed from the data) were also significantly connected during rest suggesting that these network connections to subregions within major regions of cortex are intrinsic. For some of these connections, task demands modulate activity in these intrinsic networks. Approximately half of the connections significant during task were significant during rest, indicating that some of the connections are intrinsic while others are recruited only in the service of the task. Furthermore, the network connections to traditional 'task positive' and 'task negative' (a.k.a 'default mode') regions shift from positive connectivity to negative connectivity depending on task demands. These findings demonstrate that such task-identified subregions are part of distinct networks, and that these networks have different patterns of connectivity for task as they do during rest, engaging connections both to task positive and task negative regions. These results have implications for understanding the parcellation of commonly active regions into more specific functional networks.Jennifer K RothMarcia K JohnsonFuyuze TokogluIsabella MurphyR Todd ConstablePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90672 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jennifer K Roth Marcia K Johnson Fuyuze Tokoglu Isabella Murphy R Todd Constable Modulating intrinsic connectivity: adjacent subregions within supplementary motor cortex, dorsolateral prefrontal cortex, and parietal cortex connect to separate functional networks during task and also connect during rest.
description	Supplementary motor area (SMA), the inferior frontal junction (IFJ), superior frontal junction (SFJ) and parietal cortex are active in many cognitive tasks. In a previous study, we found that subregions of each of these major areas were differentially active in component processes of executive function during working memory tasks. In the present study, each of these subregions was used as a seed in a whole brain functional connectivity analysis of working memory and resting state data. These regions show functional connectivity to different networks, thus supporting the parcellation of these major regions into functional subregions. Many regions showing significant connectivity during the working memory residual data (with task events regressed from the data) were also significantly connected during rest suggesting that these network connections to subregions within major regions of cortex are intrinsic. For some of these connections, task demands modulate activity in these intrinsic networks. Approximately half of the connections significant during task were significant during rest, indicating that some of the connections are intrinsic while others are recruited only in the service of the task. Furthermore, the network connections to traditional 'task positive' and 'task negative' (a.k.a 'default mode') regions shift from positive connectivity to negative connectivity depending on task demands. These findings demonstrate that such task-identified subregions are part of distinct networks, and that these networks have different patterns of connectivity for task as they do during rest, engaging connections both to task positive and task negative regions. These results have implications for understanding the parcellation of commonly active regions into more specific functional networks.
format	article
author	Jennifer K Roth Marcia K Johnson Fuyuze Tokoglu Isabella Murphy R Todd Constable
author_facet	Jennifer K Roth Marcia K Johnson Fuyuze Tokoglu Isabella Murphy R Todd Constable
author_sort	Jennifer K Roth
title	Modulating intrinsic connectivity: adjacent subregions within supplementary motor cortex, dorsolateral prefrontal cortex, and parietal cortex connect to separate functional networks during task and also connect during rest.
title_short	Modulating intrinsic connectivity: adjacent subregions within supplementary motor cortex, dorsolateral prefrontal cortex, and parietal cortex connect to separate functional networks during task and also connect during rest.
title_full	Modulating intrinsic connectivity: adjacent subregions within supplementary motor cortex, dorsolateral prefrontal cortex, and parietal cortex connect to separate functional networks during task and also connect during rest.
title_fullStr	Modulating intrinsic connectivity: adjacent subregions within supplementary motor cortex, dorsolateral prefrontal cortex, and parietal cortex connect to separate functional networks during task and also connect during rest.
title_full_unstemmed	Modulating intrinsic connectivity: adjacent subregions within supplementary motor cortex, dorsolateral prefrontal cortex, and parietal cortex connect to separate functional networks during task and also connect during rest.
title_sort	modulating intrinsic connectivity: adjacent subregions within supplementary motor cortex, dorsolateral prefrontal cortex, and parietal cortex connect to separate functional networks during task and also connect during rest.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/c1f29e9ecf7547a89fc77d3af190df23
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Modulating intrinsic connectivity: adjacent subregions within supplementary motor cortex, dorsolateral prefrontal cortex, and parietal cortex connect to separate functional networks during task and also connect during rest.

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