In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Syntaxin1A (Sx1A) is organized in nanoclusters in neurosecretory cells but how these nanoclusters are affected by neurotransmitter release in a living organism is unknown. Here the authors perform single molecule imaging analysis in live fly larvae and show that the lateral diffusion and trapping of...

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Autores principales:	Adekunle T. Bademosi, Elsa Lauwers, Pranesh Padmanabhan, Lorenzo Odierna, Ye Jin Chai, Andreas Papadopulos, Geoffrey J. Goodhill, Patrik Verstreken, Bruno van Swinderen, Frédéric A. Meunier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1f4a0305349438cae230c68db71b70f
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spelling	oai:doaj.org-article:c1f4a0305349438cae230c68db71b70f2021-12-02T17:33:20ZIn vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters10.1038/ncomms136602041-1723https://doaj.org/article/c1f4a0305349438cae230c68db71b70f2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13660https://doaj.org/toc/2041-1723Syntaxin1A (Sx1A) is organized in nanoclusters in neurosecretory cells but how these nanoclusters are affected by neurotransmitter release in a living organism is unknown. Here the authors perform single molecule imaging analysis in live fly larvae and show that the lateral diffusion and trapping of Sx1A in nanoclusters are altered by synaptic activity.Adekunle T. BademosiElsa LauwersPranesh PadmanabhanLorenzo OdiernaYe Jin ChaiAndreas PapadopulosGeoffrey J. GoodhillPatrik VerstrekenBruno van SwinderenFrédéric A. MeunierNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adekunle T. Bademosi Elsa Lauwers Pranesh Padmanabhan Lorenzo Odierna Ye Jin Chai Andreas Papadopulos Geoffrey J. Goodhill Patrik Verstreken Bruno van Swinderen Frédéric A. Meunier In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters
description	Syntaxin1A (Sx1A) is organized in nanoclusters in neurosecretory cells but how these nanoclusters are affected by neurotransmitter release in a living organism is unknown. Here the authors perform single molecule imaging analysis in live fly larvae and show that the lateral diffusion and trapping of Sx1A in nanoclusters are altered by synaptic activity.
format	article
author	Adekunle T. Bademosi Elsa Lauwers Pranesh Padmanabhan Lorenzo Odierna Ye Jin Chai Andreas Papadopulos Geoffrey J. Goodhill Patrik Verstreken Bruno van Swinderen Frédéric A. Meunier
author_facet	Adekunle T. Bademosi Elsa Lauwers Pranesh Padmanabhan Lorenzo Odierna Ye Jin Chai Andreas Papadopulos Geoffrey J. Goodhill Patrik Verstreken Bruno van Swinderen Frédéric A. Meunier
author_sort	Adekunle T. Bademosi
title	In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters
title_short	In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters
title_full	In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters
title_fullStr	In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters
title_full_unstemmed	In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters
title_sort	in vivo single-molecule imaging of syntaxin1a reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c1f4a0305349438cae230c68db71b70f
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In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

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