Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway

Molecular mechanisms regulating optimal myelin geometry are only partially understood. Here authors show that peripheral myelin growth is orchestrated by the Crb3/Hippo/YAP pathway, and that defects in YAP activation may underlie peripheral neuropathies caused by shorter myelin.

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Autores principales:	Ruani N. Fernando, Laurent Cotter, Claire Perrin-Tricaud, Jade Berthelot, Sylvain Bartolami, Jorge A. Pereira, Sergio Gonzalez, Ueli Suter, Nicolas Tricaud
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1f6ad2ca61c49ab91342b2741d1490a
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spelling	oai:doaj.org-article:c1f6ad2ca61c49ab91342b2741d1490a2021-12-02T16:49:57ZOptimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway10.1038/ncomms121862041-1723https://doaj.org/article/c1f6ad2ca61c49ab91342b2741d1490a2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12186https://doaj.org/toc/2041-1723Molecular mechanisms regulating optimal myelin geometry are only partially understood. Here authors show that peripheral myelin growth is orchestrated by the Crb3/Hippo/YAP pathway, and that defects in YAP activation may underlie peripheral neuropathies caused by shorter myelin.Ruani N. FernandoLaurent CotterClaire Perrin-TricaudJade BerthelotSylvain BartolamiJorge A. PereiraSergio GonzalezUeli SuterNicolas TricaudNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruani N. Fernando Laurent Cotter Claire Perrin-Tricaud Jade Berthelot Sylvain Bartolami Jorge A. Pereira Sergio Gonzalez Ueli Suter Nicolas Tricaud Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
description	Molecular mechanisms regulating optimal myelin geometry are only partially understood. Here authors show that peripheral myelin growth is orchestrated by the Crb3/Hippo/YAP pathway, and that defects in YAP activation may underlie peripheral neuropathies caused by shorter myelin.
format	article
author	Ruani N. Fernando Laurent Cotter Claire Perrin-Tricaud Jade Berthelot Sylvain Bartolami Jorge A. Pereira Sergio Gonzalez Ueli Suter Nicolas Tricaud
author_facet	Ruani N. Fernando Laurent Cotter Claire Perrin-Tricaud Jade Berthelot Sylvain Bartolami Jorge A. Pereira Sergio Gonzalez Ueli Suter Nicolas Tricaud
author_sort	Ruani N. Fernando
title	Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
title_short	Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
title_full	Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
title_fullStr	Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
title_full_unstemmed	Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
title_sort	optimal myelin elongation relies on yap activation by axonal growth and inhibition by crb3/hippo pathway
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c1f6ad2ca61c49ab91342b2741d1490a
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Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway

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