T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer.

Bone metastases, present in 70% of patients with metastatic breast cancer, lead to skeletal disease, fractures and intense pain, which are all believed to be mediated by tumor cells. Engraftment of tumor cells is supposed to be preceded by changes in the target tissue to create a permissive microenv...

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Autores principales:	Ana Carolina Monteiro, Ana Carolina Leal, Triciana Gonçalves-Silva, Ana Carolina T Mercadante, Fabiola Kestelman, Sacha Braun Chaves, Ricardo Bentes Azevedo, João P Monteiro, Adriana Bonomo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c1f7025101bf4f74aebd8c07107bc229
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spelling	oai:doaj.org-article:c1f7025101bf4f74aebd8c07107bc2292021-11-18T09:03:51ZT cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer.1932-620310.1371/journal.pone.0068171https://doaj.org/article/c1f7025101bf4f74aebd8c07107bc2292013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23935856/?tool=EBIhttps://doaj.org/toc/1932-6203Bone metastases, present in 70% of patients with metastatic breast cancer, lead to skeletal disease, fractures and intense pain, which are all believed to be mediated by tumor cells. Engraftment of tumor cells is supposed to be preceded by changes in the target tissue to create a permissive microenvironment, the pre-metastatic niche, for the establishment of the metastatic foci. In bone metastatic niche, metastatic cells stimulate bone consumption resulting in the release of growth factors that feed the tumor, establishing a vicious cycle between the bone remodeling system and the tumor itself. Yet, how the pre-metastatic niches arise in the bone tissue remains unclear. Here we show that tumor-specific T cells induce osteolytic bone disease before bone colonization. T cells pro-metastatic activity correlate with a pro-osteoclastogenic cytokine profile, including RANKL, a master regulator of osteoclastogenesis. In vivo inhibition of RANKL from tumor-specific T cells completely blocks bone loss and metastasis. Our results unveil an unexpected role for RANKL-derived from T cells in setting the pre-metastatic niche and promoting tumor spread. We believe this information can bring new possibilities for the development of prognostic and therapeutic tools based on modulation of T cell activity for prevention and treatment of bone metastasis.Ana Carolina MonteiroAna Carolina LealTriciana Gonçalves-SilvaAna Carolina T MercadanteFabiola KestelmanSacha Braun ChavesRicardo Bentes AzevedoJoão P MonteiroAdriana BonomoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68171 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana Carolina Monteiro Ana Carolina Leal Triciana Gonçalves-Silva Ana Carolina T Mercadante Fabiola Kestelman Sacha Braun Chaves Ricardo Bentes Azevedo João P Monteiro Adriana Bonomo T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer.
description	Bone metastases, present in 70% of patients with metastatic breast cancer, lead to skeletal disease, fractures and intense pain, which are all believed to be mediated by tumor cells. Engraftment of tumor cells is supposed to be preceded by changes in the target tissue to create a permissive microenvironment, the pre-metastatic niche, for the establishment of the metastatic foci. In bone metastatic niche, metastatic cells stimulate bone consumption resulting in the release of growth factors that feed the tumor, establishing a vicious cycle between the bone remodeling system and the tumor itself. Yet, how the pre-metastatic niches arise in the bone tissue remains unclear. Here we show that tumor-specific T cells induce osteolytic bone disease before bone colonization. T cells pro-metastatic activity correlate with a pro-osteoclastogenic cytokine profile, including RANKL, a master regulator of osteoclastogenesis. In vivo inhibition of RANKL from tumor-specific T cells completely blocks bone loss and metastasis. Our results unveil an unexpected role for RANKL-derived from T cells in setting the pre-metastatic niche and promoting tumor spread. We believe this information can bring new possibilities for the development of prognostic and therapeutic tools based on modulation of T cell activity for prevention and treatment of bone metastasis.
format	article
author	Ana Carolina Monteiro Ana Carolina Leal Triciana Gonçalves-Silva Ana Carolina T Mercadante Fabiola Kestelman Sacha Braun Chaves Ricardo Bentes Azevedo João P Monteiro Adriana Bonomo
author_facet	Ana Carolina Monteiro Ana Carolina Leal Triciana Gonçalves-Silva Ana Carolina T Mercadante Fabiola Kestelman Sacha Braun Chaves Ricardo Bentes Azevedo João P Monteiro Adriana Bonomo
author_sort	Ana Carolina Monteiro
title	T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer.
title_short	T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer.
title_full	T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer.
title_fullStr	T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer.
title_full_unstemmed	T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer.
title_sort	t cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c1f7025101bf4f74aebd8c07107bc229
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T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer.

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