Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

Here, Li et al. perform a genome-wide CRISPR screen to identify host dependency factors for influenza A virus infection and show that the host mRNA cap methyltransferase CMTR1 is important for viral cap snatching and that it affects expression of antiviral genes.

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Autores principales:	Bo Li, Sara M. Clohisey, Bing Shao Chia, Bo Wang, Ang Cui, Thomas Eisenhaure, Lawrence D. Schweitzer, Paul Hoover, Nicholas J. Parkinson, Aharon Nachshon, Nikki Smith, Tim Regan, David Farr, Michael U. Gutmann, Syed Irfan Bukhari, Andrew Law, Maya Sangesland, Irit Gat-Viks, Paul Digard, Shobha Vasudevan, Daniel Lingwood, David H. Dockrell, John G. Doench, J. Kenneth Baillie, Nir Hacohen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1f734a4d6574c6d950eb373c2f18352
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spelling	oai:doaj.org-article:c1f734a4d6574c6d950eb373c2f183522021-12-02T17:32:42ZGenome-wide CRISPR screen identifies host dependency factors for influenza A virus infection10.1038/s41467-019-13965-x2041-1723https://doaj.org/article/c1f734a4d6574c6d950eb373c2f183522020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13965-xhttps://doaj.org/toc/2041-1723Here, Li et al. perform a genome-wide CRISPR screen to identify host dependency factors for influenza A virus infection and show that the host mRNA cap methyltransferase CMTR1 is important for viral cap snatching and that it affects expression of antiviral genes.Bo LiSara M. ClohiseyBing Shao ChiaBo WangAng CuiThomas EisenhaureLawrence D. SchweitzerPaul HooverNicholas J. ParkinsonAharon NachshonNikki SmithTim ReganDavid FarrMichael U. GutmannSyed Irfan BukhariAndrew LawMaya SangeslandIrit Gat-ViksPaul DigardShobha VasudevanDaniel LingwoodDavid H. DockrellJohn G. DoenchJ. Kenneth BaillieNir HacohenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bo Li Sara M. Clohisey Bing Shao Chia Bo Wang Ang Cui Thomas Eisenhaure Lawrence D. Schweitzer Paul Hoover Nicholas J. Parkinson Aharon Nachshon Nikki Smith Tim Regan David Farr Michael U. Gutmann Syed Irfan Bukhari Andrew Law Maya Sangesland Irit Gat-Viks Paul Digard Shobha Vasudevan Daniel Lingwood David H. Dockrell John G. Doench J. Kenneth Baillie Nir Hacohen Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
description	Here, Li et al. perform a genome-wide CRISPR screen to identify host dependency factors for influenza A virus infection and show that the host mRNA cap methyltransferase CMTR1 is important for viral cap snatching and that it affects expression of antiviral genes.
format	article
author	Bo Li Sara M. Clohisey Bing Shao Chia Bo Wang Ang Cui Thomas Eisenhaure Lawrence D. Schweitzer Paul Hoover Nicholas J. Parkinson Aharon Nachshon Nikki Smith Tim Regan David Farr Michael U. Gutmann Syed Irfan Bukhari Andrew Law Maya Sangesland Irit Gat-Viks Paul Digard Shobha Vasudevan Daniel Lingwood David H. Dockrell John G. Doench J. Kenneth Baillie Nir Hacohen
author_facet	Bo Li Sara M. Clohisey Bing Shao Chia Bo Wang Ang Cui Thomas Eisenhaure Lawrence D. Schweitzer Paul Hoover Nicholas J. Parkinson Aharon Nachshon Nikki Smith Tim Regan David Farr Michael U. Gutmann Syed Irfan Bukhari Andrew Law Maya Sangesland Irit Gat-Viks Paul Digard Shobha Vasudevan Daniel Lingwood David H. Dockrell John G. Doench J. Kenneth Baillie Nir Hacohen
author_sort	Bo Li
title	Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
title_short	Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
title_full	Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
title_fullStr	Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
title_full_unstemmed	Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
title_sort	genome-wide crispr screen identifies host dependency factors for influenza a virus infection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c1f734a4d6574c6d950eb373c2f18352
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Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

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