Nuclear membrane protein Lem2 regulates nuclear size through membrane flow

Nuclear size scales with cell size, but the underlying mechanisms are unclear. Here, the authors report in fission yeast that the inner nuclear membrane protein Lem2 and the ER membrane protein Lnp1 are barriers to membrane flow and propose that they maintain nuclear size in proportion to cell membr...

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Autores principales:	Kazunori Kume, Helena Cantwell, Alana Burrell, Paul Nurse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1f90115a3bc463dbe14573025028420
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spelling	oai:doaj.org-article:c1f90115a3bc463dbe145730250284202021-12-02T15:35:36ZNuclear membrane protein Lem2 regulates nuclear size through membrane flow10.1038/s41467-019-09623-x2041-1723https://doaj.org/article/c1f90115a3bc463dbe145730250284202019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09623-xhttps://doaj.org/toc/2041-1723Nuclear size scales with cell size, but the underlying mechanisms are unclear. Here, the authors report in fission yeast that the inner nuclear membrane protein Lem2 and the ER membrane protein Lnp1 are barriers to membrane flow and propose that they maintain nuclear size in proportion to cell membrane content.Kazunori KumeHelena CantwellAlana BurrellPaul NurseNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kazunori Kume Helena Cantwell Alana Burrell Paul Nurse Nuclear membrane protein Lem2 regulates nuclear size through membrane flow
description	Nuclear size scales with cell size, but the underlying mechanisms are unclear. Here, the authors report in fission yeast that the inner nuclear membrane protein Lem2 and the ER membrane protein Lnp1 are barriers to membrane flow and propose that they maintain nuclear size in proportion to cell membrane content.
format	article
author	Kazunori Kume Helena Cantwell Alana Burrell Paul Nurse
author_facet	Kazunori Kume Helena Cantwell Alana Burrell Paul Nurse
author_sort	Kazunori Kume
title	Nuclear membrane protein Lem2 regulates nuclear size through membrane flow
title_short	Nuclear membrane protein Lem2 regulates nuclear size through membrane flow
title_full	Nuclear membrane protein Lem2 regulates nuclear size through membrane flow
title_fullStr	Nuclear membrane protein Lem2 regulates nuclear size through membrane flow
title_full_unstemmed	Nuclear membrane protein Lem2 regulates nuclear size through membrane flow
title_sort	nuclear membrane protein lem2 regulates nuclear size through membrane flow
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c1f90115a3bc463dbe14573025028420
work_keys_str_mv	AT kazunorikume nuclearmembraneproteinlem2regulatesnuclearsizethroughmembraneflow AT helenacantwell nuclearmembraneproteinlem2regulatesnuclearsizethroughmembraneflow AT alanaburrell nuclearmembraneproteinlem2regulatesnuclearsizethroughmembraneflow AT paulnurse nuclearmembraneproteinlem2regulatesnuclearsizethroughmembraneflow
_version_	1718386500303847424

Nuclear membrane protein Lem2 regulates nuclear size through membrane flow

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