CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression

CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression

Alterations in intrinsic plasticity are important in epilepsy. Here the authors show that the epigenetic factor CDYL regulates the gene expression of the voltage gated sodium channel, Nav1.6, which contributes to seizures in a rat model of epilepsy.

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Autores principales: Yongqing Liu, Shirong Lai, Weining Ma, Wei Ke, Chan Zhang, Shumeng Liu, Yu Zhang, Fei Pei, Shaoyi Li, Ming Yi, Yousheng Shu, Yongfeng Shang, Jing Liang, Zhuo Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c1fec91be8b04fc981937dd1ca6abdea
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spelling oai:doaj.org-article:c1fec91be8b04fc981937dd1ca6abdea2021-12-02T16:51:52ZCDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression10.1038/s41467-017-00368-z2041-1723https://doaj.org/article/c1fec91be8b04fc981937dd1ca6abdea2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00368-zhttps://doaj.org/toc/2041-1723Alterations in intrinsic plasticity are important in epilepsy. Here the authors show that the epigenetic factor CDYL regulates the gene expression of the voltage gated sodium channel, Nav1.6, which contributes to seizures in a rat model of epilepsy.Yongqing LiuShirong LaiWeining MaWei KeChan ZhangShumeng LiuYu ZhangFei PeiShaoyi LiMing YiYousheng ShuYongfeng ShangJing LiangZhuo HuangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yongqing Liu
Shirong Lai
Weining Ma
Wei Ke
Chan Zhang
Shumeng Liu
Yu Zhang
Fei Pei
Shaoyi Li
Ming Yi
Yousheng Shu
Yongfeng Shang
Jing Liang
Zhuo Huang
CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression
description Alterations in intrinsic plasticity are important in epilepsy. Here the authors show that the epigenetic factor CDYL regulates the gene expression of the voltage gated sodium channel, Nav1.6, which contributes to seizures in a rat model of epilepsy.
format article
author Yongqing Liu
Shirong Lai
Weining Ma
Wei Ke
Chan Zhang
Shumeng Liu
Yu Zhang
Fei Pei
Shaoyi Li
Ming Yi
Yousheng Shu
Yongfeng Shang
Jing Liang
Zhuo Huang
author_facet Yongqing Liu
Shirong Lai
Weining Ma
Wei Ke
Chan Zhang
Shumeng Liu
Yu Zhang
Fei Pei
Shaoyi Li
Ming Yi
Yousheng Shu
Yongfeng Shang
Jing Liang
Zhuo Huang
author_sort Yongqing Liu
title CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression
title_short CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression
title_full CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression
title_fullStr CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression
title_full_unstemmed CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression
title_sort cdyl suppresses epileptogenesis in mice through repression of axonal nav1.6 sodium channel expression
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/c1fec91be8b04fc981937dd1ca6abdea
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