Alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier

Correct assembly of intercellular junctions is required to maintain epithelial polarity and barrier function. Here Campos et al. show that the scaffold protein Alix interacts with F-actin, the Par complex and ZO-1 to ensure the formation and maintenance of the actomyosin tight junction complex in ch...

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Main Authors:	Yvan Campos, Xiaohui Qiu, Elida Gomero, Randall Wakefield, Linda Horner, Wojciech Brutkowski, Young-Goo Han, David Solecki, Sharon Frase, Antonella Bongiovanni, Alessandra d’Azzo
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/c1feeee6b4234f208945cf8f377982ec
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spelling	oai:doaj.org-article:c1feeee6b4234f208945cf8f377982ec2021-12-02T15:34:32ZAlix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier10.1038/ncomms118762041-1723https://doaj.org/article/c1feeee6b4234f208945cf8f377982ec2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11876https://doaj.org/toc/2041-1723Correct assembly of intercellular junctions is required to maintain epithelial polarity and barrier function. Here Campos et al. show that the scaffold protein Alix interacts with F-actin, the Par complex and ZO-1 to ensure the formation and maintenance of the actomyosin tight junction complex in choroid plexus epithelium.Yvan CamposXiaohui QiuElida GomeroRandall WakefieldLinda HornerWojciech BrutkowskiYoung-Goo HanDavid SoleckiSharon FraseAntonella BongiovanniAlessandra d’AzzoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yvan Campos Xiaohui Qiu Elida Gomero Randall Wakefield Linda Horner Wojciech Brutkowski Young-Goo Han David Solecki Sharon Frase Antonella Bongiovanni Alessandra d’Azzo Alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier
description	Correct assembly of intercellular junctions is required to maintain epithelial polarity and barrier function. Here Campos et al. show that the scaffold protein Alix interacts with F-actin, the Par complex and ZO-1 to ensure the formation and maintenance of the actomyosin tight junction complex in choroid plexus epithelium.
format	article
author	Yvan Campos Xiaohui Qiu Elida Gomero Randall Wakefield Linda Horner Wojciech Brutkowski Young-Goo Han David Solecki Sharon Frase Antonella Bongiovanni Alessandra d’Azzo
author_facet	Yvan Campos Xiaohui Qiu Elida Gomero Randall Wakefield Linda Horner Wojciech Brutkowski Young-Goo Han David Solecki Sharon Frase Antonella Bongiovanni Alessandra d’Azzo
author_sort	Yvan Campos
title	Alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier
title_short	Alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier
title_full	Alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier
title_fullStr	Alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier
title_full_unstemmed	Alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier
title_sort	alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c1feeee6b4234f208945cf8f377982ec
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Alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier

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