Porous Se@SiO2 nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis

Guoying Deng1,*, Chenyun Dai2,*, Jinyuan Chen1, Anqi Ji1, Jingpeng Zhao1, Yue Zhai1, Yingjie Kang3, Xijian Liu4, Yin Wang5, Qiugen Wang1 1Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 2Institute of Translation Medicine, Shanghai General...

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Autores principales:	Deng G, Dai C, Chen J, Ji A, Zhao J, Zhai Y, Kang Y, Liu X, Wang Y, Wang Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Porous Se@SiO2 nanocomposites Methylprednisolone Osteonecrosis of femoral head ROS damage ARDS Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c202b5bb53c84ca48e5818b2c8916bd7
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spelling	oai:doaj.org-article:c202b5bb53c84ca48e5818b2c8916bd72021-12-02T01:27:01ZPorous Se@SiO2 nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis1178-2013https://doaj.org/article/c202b5bb53c84ca48e5818b2c8916bd72018-03-01T00:00:00Zhttps://www.dovepress.com/porous-sesio2-nanocomposites-protect-the-femoral-head-from-methylpredn-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Guoying Deng1,, Chenyun Dai2,, Jinyuan Chen1, Anqi Ji1, Jingpeng Zhao1, Yue Zhai1, Yingjie Kang3, Xijian Liu4, Yin Wang5, Qiugen Wang1 1Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 2Institute of Translation Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 3Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; 4College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, China; 5Ultrasound Department of Shanghai Pulmonary Hospital, Tongji University, Shanghai, China *These authors contributed equally to this work Background: Methylprednisolone (MPS) is an important drug used in therapy of many diseases. However, osteonecrosis of the femoral head is a serious damage in the MPS treatment. Thus, it is imperative to develop new drugs to prevent the serious side effect of MPS. Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1β and TNF-α. And oxidative stress species (ROS) index like superoxide dismutase (SOD) and glutathione (GSH) were tested. Then, the protection effects of Se@SiO2 have in osteonecrosis of the femoral head (ONFH) were evaluated by micro CT, histologic analysis and Western-blot analysis. Results: In the present study, we found that in the rat model of ARDS, Se@SiO2 nanocomposites induced SOD and GSH indirectly to reduce ROS damage. The wet-to-dry weight ratio of lung was significantly decreased after MPS treatment compared with the control group, whereas the Se@SiO2 did not affect the reduced wet-to-dry weight ratio of MPS. Se@SiO2 also did not impair the effect of MPS on the reduction of inflammatory factors IL-1β and TNF-α, and on the alleviation of structural destruction. Furthermore, micro CT and histologic analysis confirmed that Se@SiO2 significantly alleviate MPS-induced destruction of femoral head. Moreover, compared with MPS group, Se@SiO2 could increase collagen II and aggrecan, and reduce the IL-1β level in the cartilage of femoral head. In addition, the biosafety of Se@SiO2 in vitro and in vivo were supported by cell proliferation assay and histologic analysis of main organs from rat models. Conclusion: Se@SiO2 nanocomposites have a protective effect in MPS-induced ONFH without influence on the therapeutic activity of MPS, suggesting the potential as effective drugs to avoid ONFH in MPS therapy. Keywords: porous Se@SiO2 nanocomposites, methylprednisolone, osteonecrosis of femoral head, ROS damage, ARDSDeng GDai CChen JJi AZhao JZhai YKang YLiu XWang YWang QDove Medical PressarticlePorous Se@SiO2 nanocompositesMethylprednisoloneOsteonecrosis of femoral headROS damageARDSMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 1809-1818 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Porous Se@SiO2 nanocomposites Methylprednisolone Osteonecrosis of femoral head ROS damage ARDS Medicine (General) R5-920
spellingShingle	Porous Se@SiO2 nanocomposites Methylprednisolone Osteonecrosis of femoral head ROS damage ARDS Medicine (General) R5-920 Deng G Dai C Chen J Ji A Zhao J Zhai Y Kang Y Liu X Wang Y Wang Q Porous Se@SiO2 nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis
description	Guoying Deng1,, Chenyun Dai2,, Jinyuan Chen1, Anqi Ji1, Jingpeng Zhao1, Yue Zhai1, Yingjie Kang3, Xijian Liu4, Yin Wang5, Qiugen Wang1 1Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 2Institute of Translation Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 3Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; 4College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, China; 5Ultrasound Department of Shanghai Pulmonary Hospital, Tongji University, Shanghai, China *These authors contributed equally to this work Background: Methylprednisolone (MPS) is an important drug used in therapy of many diseases. However, osteonecrosis of the femoral head is a serious damage in the MPS treatment. Thus, it is imperative to develop new drugs to prevent the serious side effect of MPS. Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1β and TNF-α. And oxidative stress species (ROS) index like superoxide dismutase (SOD) and glutathione (GSH) were tested. Then, the protection effects of Se@SiO2 have in osteonecrosis of the femoral head (ONFH) were evaluated by micro CT, histologic analysis and Western-blot analysis. Results: In the present study, we found that in the rat model of ARDS, Se@SiO2 nanocomposites induced SOD and GSH indirectly to reduce ROS damage. The wet-to-dry weight ratio of lung was significantly decreased after MPS treatment compared with the control group, whereas the Se@SiO2 did not affect the reduced wet-to-dry weight ratio of MPS. Se@SiO2 also did not impair the effect of MPS on the reduction of inflammatory factors IL-1β and TNF-α, and on the alleviation of structural destruction. Furthermore, micro CT and histologic analysis confirmed that Se@SiO2 significantly alleviate MPS-induced destruction of femoral head. Moreover, compared with MPS group, Se@SiO2 could increase collagen II and aggrecan, and reduce the IL-1β level in the cartilage of femoral head. In addition, the biosafety of Se@SiO2 in vitro and in vivo were supported by cell proliferation assay and histologic analysis of main organs from rat models. Conclusion: Se@SiO2 nanocomposites have a protective effect in MPS-induced ONFH without influence on the therapeutic activity of MPS, suggesting the potential as effective drugs to avoid ONFH in MPS therapy. Keywords: porous Se@SiO2 nanocomposites, methylprednisolone, osteonecrosis of femoral head, ROS damage, ARDS
format	article
author	Deng G Dai C Chen J Ji A Zhao J Zhai Y Kang Y Liu X Wang Y Wang Q
author_facet	Deng G Dai C Chen J Ji A Zhao J Zhai Y Kang Y Liu X Wang Y Wang Q
author_sort	Deng G
title	Porous Se@SiO2 nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis
title_short	Porous Se@SiO2 nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis
title_full	Porous Se@SiO2 nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis
title_fullStr	Porous Se@SiO2 nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis
title_full_unstemmed	Porous Se@SiO2 nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis
title_sort	porous se@sio2 nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/c202b5bb53c84ca48e5818b2c8916bd7
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Porous Se@SiO2 nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis

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