Interferon-inducible protein, IFIX, has tumor-suppressive effects in oral squamous cell carcinoma

Abstract IFIX, a newly discovered member of the interferon-inducible HIN-200 family, has been identified as a tumor suppressor in breast cancer; however, the involvement of IFIX in oral cancer are poorly understood. Here, we demonstrate a relationship between the level of IFIX expression and the inv...

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Autores principales:	Shan Wang, Fang Li, Haixia Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c2061932257d408b85d19188968cbf51
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spelling	oai:doaj.org-article:c2061932257d408b85d19188968cbf512021-12-02T19:17:05ZInterferon-inducible protein, IFIX, has tumor-suppressive effects in oral squamous cell carcinoma10.1038/s41598-021-99157-42045-2322https://doaj.org/article/c2061932257d408b85d19188968cbf512021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99157-4https://doaj.org/toc/2045-2322Abstract IFIX, a newly discovered member of the interferon-inducible HIN-200 family, has been identified as a tumor suppressor in breast cancer; however, the involvement of IFIX in oral cancer are poorly understood. Here, we demonstrate a relationship between the level of IFIX expression and the invasive or migratory abilities of oral squamous cell carcinoma. Higher IFIX expression significantly correlated with clinicopathological parameters such as the histopathological grade of clinical samples. In vitro, IFIX overexpression suppressed the invasiveness of human tongue squamous cell carcinoma CAL-27 cells, and this inhibitory effect was mediated by stabilization of the cytoskeleton through various cytokeratins along with downregulation of paxillin, an intracellular adaptor protein that promotes tumor invasion. This inhibitory effect does not appear to affect the transformation of cancer stem-like cells in this cell culture model. Altogether, these data provide novel insights into the tumor-suppressive function of IFIX, namely, stabilization of the cancer cell cytoskeleton.Shan WangFang LiHaixia FanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shan Wang Fang Li Haixia Fan Interferon-inducible protein, IFIX, has tumor-suppressive effects in oral squamous cell carcinoma
description	Abstract IFIX, a newly discovered member of the interferon-inducible HIN-200 family, has been identified as a tumor suppressor in breast cancer; however, the involvement of IFIX in oral cancer are poorly understood. Here, we demonstrate a relationship between the level of IFIX expression and the invasive or migratory abilities of oral squamous cell carcinoma. Higher IFIX expression significantly correlated with clinicopathological parameters such as the histopathological grade of clinical samples. In vitro, IFIX overexpression suppressed the invasiveness of human tongue squamous cell carcinoma CAL-27 cells, and this inhibitory effect was mediated by stabilization of the cytoskeleton through various cytokeratins along with downregulation of paxillin, an intracellular adaptor protein that promotes tumor invasion. This inhibitory effect does not appear to affect the transformation of cancer stem-like cells in this cell culture model. Altogether, these data provide novel insights into the tumor-suppressive function of IFIX, namely, stabilization of the cancer cell cytoskeleton.
format	article
author	Shan Wang Fang Li Haixia Fan
author_facet	Shan Wang Fang Li Haixia Fan
author_sort	Shan Wang
title	Interferon-inducible protein, IFIX, has tumor-suppressive effects in oral squamous cell carcinoma
title_short	Interferon-inducible protein, IFIX, has tumor-suppressive effects in oral squamous cell carcinoma
title_full	Interferon-inducible protein, IFIX, has tumor-suppressive effects in oral squamous cell carcinoma
title_fullStr	Interferon-inducible protein, IFIX, has tumor-suppressive effects in oral squamous cell carcinoma
title_full_unstemmed	Interferon-inducible protein, IFIX, has tumor-suppressive effects in oral squamous cell carcinoma
title_sort	interferon-inducible protein, ifix, has tumor-suppressive effects in oral squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c2061932257d408b85d19188968cbf51
work_keys_str_mv	AT shanwang interferoninducibleproteinifixhastumorsuppressiveeffectsinoralsquamouscellcarcinoma AT fangli interferoninducibleproteinifixhastumorsuppressiveeffectsinoralsquamouscellcarcinoma AT haixiafan interferoninducibleproteinifixhastumorsuppressiveeffectsinoralsquamouscellcarcinoma
_version_	1718376935125417984

Interferon-inducible protein, IFIX, has tumor-suppressive effects in oral squamous cell carcinoma

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