Second primary malignancy among malignant solid tumor survivors aged 85 years and older

Abstract The cancer burden in the oldest old has increased rapidly. This study aimed to investigate the epidemiology of second primary malignancy (SPM) in malignant solid tumor survivors aged 85 years and older utilizing the Surveillance, Epidemiology, and End Results (SEER) database. A total of 128...

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Autores principales:	Zhijia Zhang, Fei Liu, Yanlin Qu, Liqian Qiu, Liqun Zhang, Qiao Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c2075eb7866446f394370fcaaacdd405
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spelling	oai:doaj.org-article:c2075eb7866446f394370fcaaacdd4052021-12-02T16:56:43ZSecond primary malignancy among malignant solid tumor survivors aged 85 years and older10.1038/s41598-021-99260-62045-2322https://doaj.org/article/c2075eb7866446f394370fcaaacdd4052021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99260-6https://doaj.org/toc/2045-2322Abstract The cancer burden in the oldest old has increased rapidly. This study aimed to investigate the epidemiology of second primary malignancy (SPM) in malignant solid tumor survivors aged 85 years and older utilizing the Surveillance, Epidemiology, and End Results (SEER) database. A total of 128,466 malignant solid tumor patients had been identified between 2000 and 2011, including 6774 patients who developed a SPM. The overall crude incidence of developing a SPM was 5.3%. Considering death as a competing event, the 3, 5, and 10-year cumulative incidence was 1.9%, 3.2%, and 5.4%, respectively. Relative younger age, male gender, surgery history, local stage and first primary malignancy (FPM) site located in the urinary system were related to higher cumulative incidence. A median time interval of 24.0 months was found between diagnosis of FPM and SPM. The most common SPM site was digestive system, whereas the least common was oral cavity and pharynx. The median overall survival (OS) was 49.0 months, and the median survival after SPM was 13.0 months. Relative older age, male gender and black race were associated with worse OS and survival after SPM, as well as higher hazard ratios of death. In conclusions, this study performed a comprehensive analysis of SPM among malignant solid tumor survivors aged 85 years and older. Additional studies are needed to characterize the specific cancer type of interest.Zhijia ZhangFei LiuYanlin QuLiqian QiuLiqun ZhangQiao YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhijia Zhang Fei Liu Yanlin Qu Liqian Qiu Liqun Zhang Qiao Yang Second primary malignancy among malignant solid tumor survivors aged 85 years and older
description	Abstract The cancer burden in the oldest old has increased rapidly. This study aimed to investigate the epidemiology of second primary malignancy (SPM) in malignant solid tumor survivors aged 85 years and older utilizing the Surveillance, Epidemiology, and End Results (SEER) database. A total of 128,466 malignant solid tumor patients had been identified between 2000 and 2011, including 6774 patients who developed a SPM. The overall crude incidence of developing a SPM was 5.3%. Considering death as a competing event, the 3, 5, and 10-year cumulative incidence was 1.9%, 3.2%, and 5.4%, respectively. Relative younger age, male gender, surgery history, local stage and first primary malignancy (FPM) site located in the urinary system were related to higher cumulative incidence. A median time interval of 24.0 months was found between diagnosis of FPM and SPM. The most common SPM site was digestive system, whereas the least common was oral cavity and pharynx. The median overall survival (OS) was 49.0 months, and the median survival after SPM was 13.0 months. Relative older age, male gender and black race were associated with worse OS and survival after SPM, as well as higher hazard ratios of death. In conclusions, this study performed a comprehensive analysis of SPM among malignant solid tumor survivors aged 85 years and older. Additional studies are needed to characterize the specific cancer type of interest.
format	article
author	Zhijia Zhang Fei Liu Yanlin Qu Liqian Qiu Liqun Zhang Qiao Yang
author_facet	Zhijia Zhang Fei Liu Yanlin Qu Liqian Qiu Liqun Zhang Qiao Yang
author_sort	Zhijia Zhang
title	Second primary malignancy among malignant solid tumor survivors aged 85 years and older
title_short	Second primary malignancy among malignant solid tumor survivors aged 85 years and older
title_full	Second primary malignancy among malignant solid tumor survivors aged 85 years and older
title_fullStr	Second primary malignancy among malignant solid tumor survivors aged 85 years and older
title_full_unstemmed	Second primary malignancy among malignant solid tumor survivors aged 85 years and older
title_sort	second primary malignancy among malignant solid tumor survivors aged 85 years and older
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c2075eb7866446f394370fcaaacdd405
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Second primary malignancy among malignant solid tumor survivors aged 85 years and older

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