Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity

Abstract Deep brain stimulation (DBS) is currently a standard procedure for advanced Parkinson’s disease. Many centers employ awake physiological navigation and stimulation assessment to optimize DBS localization and outcome. To enable DBS under sedation, asleep DBS, we characterized the cortico-bas...

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Autores principales:	Jing Guang, Halen Baker, Orilia Ben-Yishay Nizri, Shimon Firman, Uri Werner-Reiss, Vadim Kapuller, Zvi Israel, Hagai Bergman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c20f783dec574a84b7bbcdf0599eba69
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spelling	oai:doaj.org-article:c20f783dec574a84b7bbcdf0599eba692021-12-02T17:06:26ZToward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity10.1038/s41531-021-00211-92373-8057https://doaj.org/article/c20f783dec574a84b7bbcdf0599eba692021-08-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00211-9https://doaj.org/toc/2373-8057Abstract Deep brain stimulation (DBS) is currently a standard procedure for advanced Parkinson’s disease. Many centers employ awake physiological navigation and stimulation assessment to optimize DBS localization and outcome. To enable DBS under sedation, asleep DBS, we characterized the cortico-basal ganglia neuronal network of two nonhuman primates under propofol, ketamine, and interleaved propofol-ketamine (IPK) sedation. Further, we compared these sedation states in the healthy and Parkinsonian condition to those of healthy sleep. Ketamine increases high-frequency power and synchronization while propofol increases low-frequency power and synchronization in polysomnography and neuronal activity recordings. Thus, ketamine does not mask the low-frequency oscillations used for physiological navigation toward the basal ganglia DBS targets. The brain spectral state under ketamine and propofol mimicked rapid eye movement (REM) and Non-REM (NREM) sleep activity, respectively, and the IPK protocol resembles the NREM-REM sleep cycle. These promising results are a meaningful step toward asleep DBS with nondistorted physiological navigation.Jing GuangHalen BakerOrilia Ben-Yishay NizriShimon FirmanUri Werner-ReissVadim KapullerZvi IsraelHagai BergmanNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Jing Guang Halen Baker Orilia Ben-Yishay Nizri Shimon Firman Uri Werner-Reiss Vadim Kapuller Zvi Israel Hagai Bergman Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity
description	Abstract Deep brain stimulation (DBS) is currently a standard procedure for advanced Parkinson’s disease. Many centers employ awake physiological navigation and stimulation assessment to optimize DBS localization and outcome. To enable DBS under sedation, asleep DBS, we characterized the cortico-basal ganglia neuronal network of two nonhuman primates under propofol, ketamine, and interleaved propofol-ketamine (IPK) sedation. Further, we compared these sedation states in the healthy and Parkinsonian condition to those of healthy sleep. Ketamine increases high-frequency power and synchronization while propofol increases low-frequency power and synchronization in polysomnography and neuronal activity recordings. Thus, ketamine does not mask the low-frequency oscillations used for physiological navigation toward the basal ganglia DBS targets. The brain spectral state under ketamine and propofol mimicked rapid eye movement (REM) and Non-REM (NREM) sleep activity, respectively, and the IPK protocol resembles the NREM-REM sleep cycle. These promising results are a meaningful step toward asleep DBS with nondistorted physiological navigation.
format	article
author	Jing Guang Halen Baker Orilia Ben-Yishay Nizri Shimon Firman Uri Werner-Reiss Vadim Kapuller Zvi Israel Hagai Bergman
author_facet	Jing Guang Halen Baker Orilia Ben-Yishay Nizri Shimon Firman Uri Werner-Reiss Vadim Kapuller Zvi Israel Hagai Bergman
author_sort	Jing Guang
title	Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity
title_short	Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity
title_full	Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity
title_fullStr	Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity
title_full_unstemmed	Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity
title_sort	toward asleep dbs: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics nrem/rem sleep activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c20f783dec574a84b7bbcdf0599eba69
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Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity

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