Functional Analysis of the Rhoptry Kinome during Chronic <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection

ABSTRACT Toxoplasma gondii is one of the most common parasitic infections of humans worldwide. Once exposed, humans remain infected with T. gondii for life, and there are no therapeutics capable of eliminating a chronic infection. In the search for novel drug targets, T. gondii is known to contain s...

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Autor principal:	Laura J. Knoll
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c2115cd444b0484d9f62ce4f408389f3
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spelling	oai:doaj.org-article:c2115cd444b0484d9f62ce4f408389f32021-11-15T15:50:17ZFunctional Analysis of the Rhoptry Kinome during Chronic <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection10.1128/mBio.00842-162150-7511https://doaj.org/article/c2115cd444b0484d9f62ce4f408389f32016-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00842-16https://doaj.org/toc/2150-7511ABSTRACT Toxoplasma gondii is one of the most common parasitic infections of humans worldwide. Once exposed, humans remain infected with T. gondii for life, and there are no therapeutics capable of eliminating a chronic infection. In the search for novel drug targets, T. gondii is known to contain several unique secretory organelles, one of which is called the rhoptries. Rhoptry organelles contain and secrete numerous proteins with kinase domains, but the roles of most of these kinases during infection remain unknown. In a recent mBio article, B. A. Fox et al. [mBio 7(3):e00193-16, 2016, http://dx.doi.org/10.1128/mBio.00193-16] performed a tour de force deletion analysis of 31 rhoptry kinases and examined their roles in the development of chronic infection. While rhoptry kinase deletion strains that displayed an acute infection defect also showed a reduction in chronic infection cyst burden, two rhoptry kinase deletion strains had decreased cyst burden without any change in acute virulence. These results indicate the necessity of the rhoptry kinases for the establishment and perhaps maintenance of chronic infection. They also highlight the potential of these kinases as drug targets to clear chronic infection or as candidates to generate a nonpersisting vaccine.Laura J. KnollAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 3 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Laura J. Knoll Functional Analysis of the Rhoptry Kinome during Chronic <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection
description	ABSTRACT Toxoplasma gondii is one of the most common parasitic infections of humans worldwide. Once exposed, humans remain infected with T. gondii for life, and there are no therapeutics capable of eliminating a chronic infection. In the search for novel drug targets, T. gondii is known to contain several unique secretory organelles, one of which is called the rhoptries. Rhoptry organelles contain and secrete numerous proteins with kinase domains, but the roles of most of these kinases during infection remain unknown. In a recent mBio article, B. A. Fox et al. [mBio 7(3):e00193-16, 2016, http://dx.doi.org/10.1128/mBio.00193-16] performed a tour de force deletion analysis of 31 rhoptry kinases and examined their roles in the development of chronic infection. While rhoptry kinase deletion strains that displayed an acute infection defect also showed a reduction in chronic infection cyst burden, two rhoptry kinase deletion strains had decreased cyst burden without any change in acute virulence. These results indicate the necessity of the rhoptry kinases for the establishment and perhaps maintenance of chronic infection. They also highlight the potential of these kinases as drug targets to clear chronic infection or as candidates to generate a nonpersisting vaccine.
format	article
author	Laura J. Knoll
author_facet	Laura J. Knoll
author_sort	Laura J. Knoll
title	Functional Analysis of the Rhoptry Kinome during Chronic <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection
title_short	Functional Analysis of the Rhoptry Kinome during Chronic <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection
title_full	Functional Analysis of the Rhoptry Kinome during Chronic <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection
title_fullStr	Functional Analysis of the Rhoptry Kinome during Chronic <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection
title_full_unstemmed	Functional Analysis of the Rhoptry Kinome during Chronic <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection
title_sort	functional analysis of the rhoptry kinome during chronic <named-content content-type="genus-species">toxoplasma gondii</named-content> infection
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/c2115cd444b0484d9f62ce4f408389f3
work_keys_str_mv	AT laurajknoll functionalanalysisoftherhoptrykinomeduringchronicnamedcontentcontenttypegenusspeciestoxoplasmagondiinamedcontentinfection
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Functional Analysis of the Rhoptry Kinome during Chronic <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection

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