Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

Yicheng Cheng,1 Jiang Wu,1 Bo Gao,1 Xianghui Zhao,2 Junyan Yao,3 Shenglin Mei,1 Liang Zhang,4 Huifang Ren1 1Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, 2Institute of Neuroscience, School of Basic Medicine, Fourth Military Medical University, 3Department o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cheng YC, Wu J, Gao B, Zhao XH, Yao JY, Mei SL, Zhang L, Ren HF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c212e5cb87cb4116a89c0418919e4b56
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c212e5cb87cb4116a89c0418919e4b56
record_format	dspace
spelling	oai:doaj.org-article:c212e5cb87cb4116a89c0418919e4b562021-12-02T05:08:47ZFabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium1176-91141178-2013https://doaj.org/article/c212e5cb87cb4116a89c0418919e4b562012-11-01T00:00:00Zhttp://www.dovepress.com/fabrication-and-in-vitro-release-behavior-of-a-novel-antibacterial-coa-a11451https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yicheng Cheng,1 Jiang Wu,1 Bo Gao,1 Xianghui Zhao,2 Junyan Yao,3 Shenglin Mei,1 Liang Zhang,4 Huifang Ren1 1Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, 2Institute of Neuroscience, School of Basic Medicine, Fourth Military Medical University, 3Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, 4Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi&#39;an, ChinaYicheng Cheng and Jiang Wu contributed equally to this workBackground: Dental implants have become increasingly common for the management of missing teeth. However, peri-implant infection remains a problem, is usually difficult to treat, and may lead eventually to dental implant failure. The aim of this study was to fabricate a novel antibacterial coating containing a halogenated furanone compound, ie, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone (BBF)-loaded poly(L-lactic acid) (PLLA) nanoparticles on microarc-oxidized titanium and to evaluate its release behavior in vitro.Methods: BBF-loaded PLLA nanoparticles were prepared using the emulsion solvent-evaporation method, and the antibacterial coating was fabricated by cross-linking BBF-loaded PLLA nanoparticles with gelatin on microarc-oxidized titanium.Results: The BBF-loaded PLLA nanoparticles had a small particle size (408 &plusmn; 14 nm), a low polydispersity index (0.140 &plusmn; 0.008), a high encapsulation efficiency (72.44% &plusmn; 1.27%), and a fine spherical shape with a smooth surface. The morphology of the fabricated antibacterial coating showed that the BBF-loaded PLLA nanoparticles were well distributed in the pores of the microarc oxidation coating, and were cross-linked with each other and the wall pores by gelatin. The release study indicated that the antibacterial coating could achieve sustained release of BBF for 60 days, with a slight initial burst release during the first 4 hours.Conclusion: The novel antibacterial coating fabricated in this study is a potentially promising method for prevention of early peri-implant infection.Keywords: antibacterial, coating, halogenated furanone, nanoparticles, microarc oxidation, sustained releaseCheng YCWu JGao BZhao XHYao JYMei SLZhang LRen HFDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5641-5652 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Cheng YC Wu J Gao B Zhao XH Yao JY Mei SL Zhang L Ren HF Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium
description	Yicheng Cheng,1 Jiang Wu,1 Bo Gao,1 Xianghui Zhao,2 Junyan Yao,3 Shenglin Mei,1 Liang Zhang,4 Huifang Ren1 1Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, 2Institute of Neuroscience, School of Basic Medicine, Fourth Military Medical University, 3Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, 4Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi&#39;an, ChinaYicheng Cheng and Jiang Wu contributed equally to this workBackground: Dental implants have become increasingly common for the management of missing teeth. However, peri-implant infection remains a problem, is usually difficult to treat, and may lead eventually to dental implant failure. The aim of this study was to fabricate a novel antibacterial coating containing a halogenated furanone compound, ie, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone (BBF)-loaded poly(L-lactic acid) (PLLA) nanoparticles on microarc-oxidized titanium and to evaluate its release behavior in vitro.Methods: BBF-loaded PLLA nanoparticles were prepared using the emulsion solvent-evaporation method, and the antibacterial coating was fabricated by cross-linking BBF-loaded PLLA nanoparticles with gelatin on microarc-oxidized titanium.Results: The BBF-loaded PLLA nanoparticles had a small particle size (408 &plusmn; 14 nm), a low polydispersity index (0.140 &plusmn; 0.008), a high encapsulation efficiency (72.44% &plusmn; 1.27%), and a fine spherical shape with a smooth surface. The morphology of the fabricated antibacterial coating showed that the BBF-loaded PLLA nanoparticles were well distributed in the pores of the microarc oxidation coating, and were cross-linked with each other and the wall pores by gelatin. The release study indicated that the antibacterial coating could achieve sustained release of BBF for 60 days, with a slight initial burst release during the first 4 hours.Conclusion: The novel antibacterial coating fabricated in this study is a potentially promising method for prevention of early peri-implant infection.Keywords: antibacterial, coating, halogenated furanone, nanoparticles, microarc oxidation, sustained release
format	article
author	Cheng YC Wu J Gao B Zhao XH Yao JY Mei SL Zhang L Ren HF
author_facet	Cheng YC Wu J Gao B Zhao XH Yao JY Mei SL Zhang L Ren HF
author_sort	Cheng YC
title	Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium
title_short	Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium
title_full	Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium
title_fullStr	Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium
title_full_unstemmed	Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium
title_sort	fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(l-lactic acid) nanoparticles on microarc-oxidized titanium
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/c212e5cb87cb4116a89c0418919e4b56
work_keys_str_mv	AT chengyc fabricationandinvitroreleasebehaviorofanovelantibacterialcoatingcontaininghalogenatedfuranoneloadedpolyllacticacidnanoparticlesonmicroarcoxidizedtitanium AT wuj fabricationandinvitroreleasebehaviorofanovelantibacterialcoatingcontaininghalogenatedfuranoneloadedpolyllacticacidnanoparticlesonmicroarcoxidizedtitanium AT gaob fabricationandinvitroreleasebehaviorofanovelantibacterialcoatingcontaininghalogenatedfuranoneloadedpolyllacticacidnanoparticlesonmicroarcoxidizedtitanium AT zhaoxh fabricationandinvitroreleasebehaviorofanovelantibacterialcoatingcontaininghalogenatedfuranoneloadedpolyllacticacidnanoparticlesonmicroarcoxidizedtitanium AT yaojy fabricationandinvitroreleasebehaviorofanovelantibacterialcoatingcontaininghalogenatedfuranoneloadedpolyllacticacidnanoparticlesonmicroarcoxidizedtitanium AT meisl fabricationandinvitroreleasebehaviorofanovelantibacterialcoatingcontaininghalogenatedfuranoneloadedpolyllacticacidnanoparticlesonmicroarcoxidizedtitanium AT zhangl fabricationandinvitroreleasebehaviorofanovelantibacterialcoatingcontaininghalogenatedfuranoneloadedpolyllacticacidnanoparticlesonmicroarcoxidizedtitanium AT renhf fabricationandinvitroreleasebehaviorofanovelantibacterialcoatingcontaininghalogenatedfuranoneloadedpolyllacticacidnanoparticlesonmicroarcoxidizedtitanium
_version_	1718400617320284160

Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

Ejemplares similares