Potential biomarkers in personality disorders: current state and future research

This review article presents the most appropriate strategies for examining the phenotype for personality disorders. At present there are many neurobiological and molecular studies that suggest a genetic predisposition to different traits representative of expressed personality disorders. Nonetheless...

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Autores principales:	Manuela Valencia Piedrahita, Jorge Mauricio Cuartas Arias
Formato:	article
Lenguaje:	EN ES
Publicado:	Universidad de San Buenaventura 2016
Materias:	personality disorders ERPs biomarkers candidate genes. Psychology BF1-990
Acceso en línea:	https://doaj.org/article/c21517c791fa40918a5111f6c31ce613
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spelling	oai:doaj.org-article:c21517c791fa40918a5111f6c31ce6132021-11-25T02:21:50ZPotential biomarkers in personality disorders: current state and future research10.21500/20112084.21052011-20842011-7922https://doaj.org/article/c21517c791fa40918a5111f6c31ce6132016-01-01T00:00:00Zhttps://revistas.usb.edu.co/index.php/IJPR/article/view/2105https://doaj.org/toc/2011-2084https://doaj.org/toc/2011-7922This review article presents the most appropriate strategies for examining the phenotype for personality disorders. At present there are many neurobiological and molecular studies that suggest a genetic predisposition to different traits representative of expressed personality disorders. Nonetheless, it has not been possible to accurately and successfully replicate such results due to some difficulties regarding the sensitivity, specificity and validity of the clinical evaluation methods, and the size and type of the chosen population and experimental designs used for research. Unfortunately, diagnoses done in psychiatry and psychology have a classification system based on the prevalence and intensity of symptoms and do not take into account the etiology, neurobiology, epidemiology, genetics, and drug responses. On the other hand, explaining the phenomenology of personality disorderes and how genes work together to express this phenotype implies a revision of the chaos theory, addressing the connection between neurodevelopment, significantly stressful events during early childhood and epigenetic modifications in DNA related to stochastic events which may contribute to the development of normal or abnormal behaviorManuela Valencia PiedrahitaJorge Mauricio Cuartas AriasUniversidad de San Buenaventuraarticlepersonality disordersERPsbiomarkerscandidate genes.PsychologyBF1-990ENESInternational Journal of Psychological Research, Vol 9, Iss 1 (2016)
institution	DOAJ
collection	DOAJ
language	EN ES
topic	personality disorders ERPs biomarkers candidate genes. Psychology BF1-990
spellingShingle	personality disorders ERPs biomarkers candidate genes. Psychology BF1-990 Manuela Valencia Piedrahita Jorge Mauricio Cuartas Arias Potential biomarkers in personality disorders: current state and future research
description	This review article presents the most appropriate strategies for examining the phenotype for personality disorders. At present there are many neurobiological and molecular studies that suggest a genetic predisposition to different traits representative of expressed personality disorders. Nonetheless, it has not been possible to accurately and successfully replicate such results due to some difficulties regarding the sensitivity, specificity and validity of the clinical evaluation methods, and the size and type of the chosen population and experimental designs used for research. Unfortunately, diagnoses done in psychiatry and psychology have a classification system based on the prevalence and intensity of symptoms and do not take into account the etiology, neurobiology, epidemiology, genetics, and drug responses. On the other hand, explaining the phenomenology of personality disorderes and how genes work together to express this phenotype implies a revision of the chaos theory, addressing the connection between neurodevelopment, significantly stressful events during early childhood and epigenetic modifications in DNA related to stochastic events which may contribute to the development of normal or abnormal behavior
format	article
author	Manuela Valencia Piedrahita Jorge Mauricio Cuartas Arias
author_facet	Manuela Valencia Piedrahita Jorge Mauricio Cuartas Arias
author_sort	Manuela Valencia Piedrahita
title	Potential biomarkers in personality disorders: current state and future research
title_short	Potential biomarkers in personality disorders: current state and future research
title_full	Potential biomarkers in personality disorders: current state and future research
title_fullStr	Potential biomarkers in personality disorders: current state and future research
title_full_unstemmed	Potential biomarkers in personality disorders: current state and future research
title_sort	potential biomarkers in personality disorders: current state and future research
publisher	Universidad de San Buenaventura
publishDate	2016
url	https://doaj.org/article/c21517c791fa40918a5111f6c31ce613
work_keys_str_mv	AT manuelavalenciapiedrahita potentialbiomarkersinpersonalitydisorderscurrentstateandfutureresearch AT jorgemauriciocuartasarias potentialbiomarkersinpersonalitydisorderscurrentstateandfutureresearch
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Potential biomarkers in personality disorders: current state and future research

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