Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome

Abstract There are conflicting data on the impact of zinc transporter 8 (ZNT8) gene variations on the metabolic syndrome (MetS). Hence, the effects of the interaction between rs13266634 and dietary factors on the risk of MetS were investigated in this study. Subjects of this nested case-control stud...

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Autores principales:	Firoozeh Hosseini-Esfahani, Parvin Mirmiran, Gelareh Koochakpoor, Maryam S. Daneshpour, Kamran Guity, Fereidoun Azizi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c215673a4d05463db69aa34d8dc99f29
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spelling	oai:doaj.org-article:c215673a4d05463db69aa34d8dc99f292021-12-02T12:31:55ZSome dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome10.1038/s41598-017-01762-92045-2322https://doaj.org/article/c215673a4d05463db69aa34d8dc99f292017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01762-9https://doaj.org/toc/2045-2322Abstract There are conflicting data on the impact of zinc transporter 8 (ZNT8) gene variations on the metabolic syndrome (MetS). Hence, the effects of the interaction between rs13266634 and dietary factors on the risk of MetS were investigated in this study. Subjects of this nested case-control study were selected from the participants in Tehran Lipid and Glucose Study. Each of the cases (n = 817) was individually matched with a control. Dietary patterns were determined using factor analysis. The ZNT8 rs13266634 were genotyped by the Tetra-refractory mutation system-polymerase chain reaction analysis. Two dietary patterns were extracted. There were no significant interactions between the ZNT8 SNP and the dietary patterns on the risk of MetS or its components. An interaction was observed between rs13266634 and the omega-3 fatty acid intakes on the risk of MetS in subjects with the CC genotype (P interaction < 0.01). Zinc modified the association of the ZNT8 variant with high fasting blood sugar (P interaction = 0.05) in CC genotype carriers. An interaction was also observed between rs13266634 and salty snacks at the risk of abdominal obesity (P interaction < 0.05). Our findings suggest an interaction between omega-3 fatty acids, zinc, salty snacks and rs13266634, which may affect the risk of MetS or its components.Firoozeh Hosseini-EsfahaniParvin MirmiranGelareh KoochakpoorMaryam S. DaneshpourKamran GuityFereidoun AziziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Firoozeh Hosseini-Esfahani Parvin Mirmiran Gelareh Koochakpoor Maryam S. Daneshpour Kamran Guity Fereidoun Azizi Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome
description	Abstract There are conflicting data on the impact of zinc transporter 8 (ZNT8) gene variations on the metabolic syndrome (MetS). Hence, the effects of the interaction between rs13266634 and dietary factors on the risk of MetS were investigated in this study. Subjects of this nested case-control study were selected from the participants in Tehran Lipid and Glucose Study. Each of the cases (n = 817) was individually matched with a control. Dietary patterns were determined using factor analysis. The ZNT8 rs13266634 were genotyped by the Tetra-refractory mutation system-polymerase chain reaction analysis. Two dietary patterns were extracted. There were no significant interactions between the ZNT8 SNP and the dietary patterns on the risk of MetS or its components. An interaction was observed between rs13266634 and the omega-3 fatty acid intakes on the risk of MetS in subjects with the CC genotype (P interaction < 0.01). Zinc modified the association of the ZNT8 variant with high fasting blood sugar (P interaction = 0.05) in CC genotype carriers. An interaction was also observed between rs13266634 and salty snacks at the risk of abdominal obesity (P interaction < 0.05). Our findings suggest an interaction between omega-3 fatty acids, zinc, salty snacks and rs13266634, which may affect the risk of MetS or its components.
format	article
author	Firoozeh Hosseini-Esfahani Parvin Mirmiran Gelareh Koochakpoor Maryam S. Daneshpour Kamran Guity Fereidoun Azizi
author_facet	Firoozeh Hosseini-Esfahani Parvin Mirmiran Gelareh Koochakpoor Maryam S. Daneshpour Kamran Guity Fereidoun Azizi
author_sort	Firoozeh Hosseini-Esfahani
title	Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome
title_short	Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome
title_full	Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome
title_fullStr	Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome
title_full_unstemmed	Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome
title_sort	some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c215673a4d05463db69aa34d8dc99f29
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Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome

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