A Deep-Learning Pipeline for TSS Coverage Imputation From Shallow Cell-Free DNA Sequencing

Cell-free DNA (cfDNA) serves as a footprint of the nucleosome occupancy status of transcription start sites (TSSs), and has been subject to wide development for use in noninvasive health monitoring and disease detection. However, the requirement for high sequencing depth limits its clinical use. Her...

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Autores principales: Bo-Wei Han, Xu Yang, Shou-Fang Qu, Zhi-Wei Guo, Li-Min Huang, Kun Li, Guo-Jun Ouyang, Geng-Xi Cai, Wei-Wei Xiao, Rong-Tao Weng, Shun Xu, Jie Huang, Xue-Xi Yang, Ying-Song Wu
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/c217fd3d6f434770b3db9fd65ec30c96
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