Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers.
<h4>Background</h4>It is time-consuming to obtain the square root of airway wall area of the hypothetical airway with an internal perimeter of 10 mm (√Aaw at Pi10), a comparable index of airway dimensions in chronic obstructive pulmonary disease (COPD), from all airways of the whole lung...
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Public Library of Science (PLoS)
2014
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oai:doaj.org-article:c21aa943760a41ddbad49fb0e9f771ca2021-11-18T08:18:06ZAirway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers.1932-620310.1371/journal.pone.0098335https://doaj.org/article/c21aa943760a41ddbad49fb0e9f771ca2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24865661/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>It is time-consuming to obtain the square root of airway wall area of the hypothetical airway with an internal perimeter of 10 mm (√Aaw at Pi10), a comparable index of airway dimensions in chronic obstructive pulmonary disease (COPD), from all airways of the whole lungs using 3-dimensional computed tomography (CT) analysis. We hypothesized that √Aaw at Pi10 differs among the five lung lobes and √Aaw at Pi10 derived from one certain lung lobe has a high level of agreement with that derived from the whole lungs in smokers.<h4>Methods</h4>Pulmonary function tests and chest volumetric CTs were performed in 157 male smokers (102 COPD, 55 non-COPD). All visible bronchial segments from the 3rd to 5th generations were segmented and measured using commercially available 3-dimensional CT analysis software. √Aaw at Pi10 of each lung lobe was estimated from all measurable bronchial segments of that lobe.<h4>Results</h4>Using a mixed-effects model, √Aaw at Pi10 differed significantly among the five lung lobes (R(2) = 0.78, P<0.0001). The Bland-Altman plots show that √Aaw at Pi10 derived from the right or left upper lobe had a high level of agreement with that derived from the whole lungs, while √Aaw at Pi10 derived from the right or left lower lobe did not.<h4>Conclusion</h4>In male smokers, CT-derived airway wall area differs among the five lung lobes, and airway wall area derived from the right or left upper lobe is representative of the whole lungs.Nguyen Van ThoLe Thi Huyen TrangYoshitaka MurakamiEmiko OgawaYasushi RyujinRie KandaHiroaki NakagawaKenichi GotoKentaro FukunagaYuichi HigamiRuriko SetoTaishi NagaoTetsuya OgumaMasafumi YamaguchiLe Thi Tuyet LanYasutaka NakanoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e98335 (2014) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine R Science Q |
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Medicine R Science Q Nguyen Van Tho Le Thi Huyen Trang Yoshitaka Murakami Emiko Ogawa Yasushi Ryujin Rie Kanda Hiroaki Nakagawa Kenichi Goto Kentaro Fukunaga Yuichi Higami Ruriko Seto Taishi Nagao Tetsuya Oguma Masafumi Yamaguchi Le Thi Tuyet Lan Yasutaka Nakano Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers. |
| description |
<h4>Background</h4>It is time-consuming to obtain the square root of airway wall area of the hypothetical airway with an internal perimeter of 10 mm (√Aaw at Pi10), a comparable index of airway dimensions in chronic obstructive pulmonary disease (COPD), from all airways of the whole lungs using 3-dimensional computed tomography (CT) analysis. We hypothesized that √Aaw at Pi10 differs among the five lung lobes and √Aaw at Pi10 derived from one certain lung lobe has a high level of agreement with that derived from the whole lungs in smokers.<h4>Methods</h4>Pulmonary function tests and chest volumetric CTs were performed in 157 male smokers (102 COPD, 55 non-COPD). All visible bronchial segments from the 3rd to 5th generations were segmented and measured using commercially available 3-dimensional CT analysis software. √Aaw at Pi10 of each lung lobe was estimated from all measurable bronchial segments of that lobe.<h4>Results</h4>Using a mixed-effects model, √Aaw at Pi10 differed significantly among the five lung lobes (R(2) = 0.78, P<0.0001). The Bland-Altman plots show that √Aaw at Pi10 derived from the right or left upper lobe had a high level of agreement with that derived from the whole lungs, while √Aaw at Pi10 derived from the right or left lower lobe did not.<h4>Conclusion</h4>In male smokers, CT-derived airway wall area differs among the five lung lobes, and airway wall area derived from the right or left upper lobe is representative of the whole lungs. |
| format |
article |
| author |
Nguyen Van Tho Le Thi Huyen Trang Yoshitaka Murakami Emiko Ogawa Yasushi Ryujin Rie Kanda Hiroaki Nakagawa Kenichi Goto Kentaro Fukunaga Yuichi Higami Ruriko Seto Taishi Nagao Tetsuya Oguma Masafumi Yamaguchi Le Thi Tuyet Lan Yasutaka Nakano |
| author_facet |
Nguyen Van Tho Le Thi Huyen Trang Yoshitaka Murakami Emiko Ogawa Yasushi Ryujin Rie Kanda Hiroaki Nakagawa Kenichi Goto Kentaro Fukunaga Yuichi Higami Ruriko Seto Taishi Nagao Tetsuya Oguma Masafumi Yamaguchi Le Thi Tuyet Lan Yasutaka Nakano |
| author_sort |
Nguyen Van Tho |
| title |
Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers. |
| title_short |
Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers. |
| title_full |
Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers. |
| title_fullStr |
Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers. |
| title_full_unstemmed |
Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers. |
| title_sort |
airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/c21aa943760a41ddbad49fb0e9f771ca |
| work_keys_str_mv |
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