Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice
Boyan Liu,1– 3,* Yunbo Xie,2,4,* Jun Chen,4 Junli Xue,1– 3 Xiaoyi Zhang,2 Min Zhao,2 Xiubin Jia,2 Yiwei Wang,4 Shucun Qin1,2 1The Second Affiliated Hospital of Shandong First Medical University, Tai’an, 271000, People’s Republic of China; 2Taishan Institute for Hydrogen Biomedicine,...
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Dove Medical Press
2021
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oai:doaj.org-article:c21ae2096d5c4151b1c4459a611f2c742021-12-02T19:35:47ZProtective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice1178-7031https://doaj.org/article/c21ae2096d5c4151b1c4459a611f2c742021-10-01T00:00:00Zhttps://www.dovepress.com/protective-effect-of-molecular-hydrogen-following-different-routes-of--peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Boyan Liu,1– 3,* Yunbo Xie,2,4,* Jun Chen,4 Junli Xue,1– 3 Xiaoyi Zhang,2 Min Zhao,2 Xiubin Jia,2 Yiwei Wang,4 Shucun Qin1,2 1The Second Affiliated Hospital of Shandong First Medical University, Tai’an, 271000, People’s Republic of China; 2Taishan Institute for Hydrogen Biomedicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’an, 271000, People’s Republic of China; 3College of Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, People’s Republic of China; 4Department of General Practice, The Affiliated Hospital of Chengde Medical University, Chengde, 067000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shucun QinThe Second Affiliated Hospital of Shandong First Medical University, Tai’an, 271000, People’s Republic of ChinaTel/Fax +86 538 6222986Email scqin@sdfmu.edu.cnYiwei WangDepartment of General Practice, The Affiliated Hospital of Chengde Medical University, Chengde, 067000, People’s Republic of ChinaTel/Fax +86 314 2279511Email chengdewyw@126.comBackground: Molecular hydrogen (H2) has been recognized as an effective antioxidant with no or little side effects. While it is known that oxidative stress is closely associated with aging, the beneficial effect of H2 on oxidative stress-related aging is still unclear. In this study, a mouse model of D-galactose-induced aging was employed to investigate the protective effects of H2.Methods: The mice were administrated of H2 via different routes (4% H2 inhalation, H2-rich water drinking, and H2-rich saline injection), the aging-related biomarkers in plasma and the oxidative stress in different tissues were measured.Results: The results showed that H2 improved aging-related biomarkers, ie, total antioxidant capacity, advanced glycation end products, tumor necrosis factor-α, free fatty acids, and alanine aminotransferase in plasma. Furthermore, H2 alleviated oxidative stress in the liver, brain, and heart by reducing the levels of lipid peroxidation and malondialdehyde and increasing the activity of superoxide dismutase. In addition, it seems that 4% H2 inhalation was the most effective regarding the amount of H2 taken up and in reducing the markers of oxidative stress in some of the tissues; however, the other routes of administration resulted in the same efficacy in most indicators.Conclusion: H2 can prevent oxidative stress in D-galactose-induced aging mice when administered by different routes.Keywords: molecular hydrogen, administration routes, oxidative stress, aging, D-galactoseLiu BXie YChen JXue JZhang XZhao MJia XWang YQin SDove Medical Pressarticlemolecular hydrogenadministration routesoxidative stressagingd-galactosePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5541-5550 (2021) |
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molecular hydrogen administration routes oxidative stress aging d-galactose Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
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molecular hydrogen administration routes oxidative stress aging d-galactose Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Liu B Xie Y Chen J Xue J Zhang X Zhao M Jia X Wang Y Qin S Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice |
| description |
Boyan Liu,1– 3,* Yunbo Xie,2,4,* Jun Chen,4 Junli Xue,1– 3 Xiaoyi Zhang,2 Min Zhao,2 Xiubin Jia,2 Yiwei Wang,4 Shucun Qin1,2 1The Second Affiliated Hospital of Shandong First Medical University, Tai’an, 271000, People’s Republic of China; 2Taishan Institute for Hydrogen Biomedicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’an, 271000, People’s Republic of China; 3College of Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, People’s Republic of China; 4Department of General Practice, The Affiliated Hospital of Chengde Medical University, Chengde, 067000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shucun QinThe Second Affiliated Hospital of Shandong First Medical University, Tai’an, 271000, People’s Republic of ChinaTel/Fax +86 538 6222986Email scqin@sdfmu.edu.cnYiwei WangDepartment of General Practice, The Affiliated Hospital of Chengde Medical University, Chengde, 067000, People’s Republic of ChinaTel/Fax +86 314 2279511Email chengdewyw@126.comBackground: Molecular hydrogen (H2) has been recognized as an effective antioxidant with no or little side effects. While it is known that oxidative stress is closely associated with aging, the beneficial effect of H2 on oxidative stress-related aging is still unclear. In this study, a mouse model of D-galactose-induced aging was employed to investigate the protective effects of H2.Methods: The mice were administrated of H2 via different routes (4% H2 inhalation, H2-rich water drinking, and H2-rich saline injection), the aging-related biomarkers in plasma and the oxidative stress in different tissues were measured.Results: The results showed that H2 improved aging-related biomarkers, ie, total antioxidant capacity, advanced glycation end products, tumor necrosis factor-α, free fatty acids, and alanine aminotransferase in plasma. Furthermore, H2 alleviated oxidative stress in the liver, brain, and heart by reducing the levels of lipid peroxidation and malondialdehyde and increasing the activity of superoxide dismutase. In addition, it seems that 4% H2 inhalation was the most effective regarding the amount of H2 taken up and in reducing the markers of oxidative stress in some of the tissues; however, the other routes of administration resulted in the same efficacy in most indicators.Conclusion: H2 can prevent oxidative stress in D-galactose-induced aging mice when administered by different routes.Keywords: molecular hydrogen, administration routes, oxidative stress, aging, D-galactose |
| format |
article |
| author |
Liu B Xie Y Chen J Xue J Zhang X Zhao M Jia X Wang Y Qin S |
| author_facet |
Liu B Xie Y Chen J Xue J Zhang X Zhao M Jia X Wang Y Qin S |
| author_sort |
Liu B |
| title |
Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice |
| title_short |
Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice |
| title_full |
Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice |
| title_fullStr |
Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice |
| title_full_unstemmed |
Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice |
| title_sort |
protective effect of molecular hydrogen following different routes of administration on d-galactose-induced aging mice |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/c21ae2096d5c4151b1c4459a611f2c74 |
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