Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation

Abstract To describe the perinatal outcomes of twin pregnancies with preterm premature rupture of membranes (PPROM) before 34 weeks’ gestation and identify factors associated with discharge without severe or moderate-severe neonatal morbidity. This study was conducted as a retrospective analysis of...

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Autores principales:	Shuwei Zhou, Yajun Yang, XiaoYan Zhang, Xiaoling Mu, Quan Quan, Qimei Zhong, Lingwei Mei, Lan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c21ea009629d47ecbfe189cd57eabc07
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spelling	oai:doaj.org-article:c21ea009629d47ecbfe189cd57eabc072021-12-05T12:11:33ZPerinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation10.1038/s41598-021-02884-x2045-2322https://doaj.org/article/c21ea009629d47ecbfe189cd57eabc072021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02884-xhttps://doaj.org/toc/2045-2322Abstract To describe the perinatal outcomes of twin pregnancies with preterm premature rupture of membranes (PPROM) before 34 weeks’ gestation and identify factors associated with discharge without severe or moderate-severe neonatal morbidity. This study was conducted as a retrospective analysis of twin pregnancies with PPROM occurring at 24 0/7 to 33 6/7 weeks’ gestation. Perinatal outcomes were assessed by gestational age (GA) at PPROM and compared between PPROM and non PPROM twins. Factors associated with discharge without severe or moderate-severe neonatal morbidity were identified using logistic regression analysis. Of the 180 pregnancies (360 foetuses), only 17 (9.4%) women remained pregnant 7 days after PPROM. There were 10 (2.8%) cases of prenatal or neonatal death; 303 (84.2%) and 177 (49.2%) neonates were discharged without severe or moderate-severe morbidity, respectively. As GA at PPROM increased, the adverse obstetric and neonatal outcomes decreased, especially after 32 weeks. There was no significant difference in general neonatal outcomes between PPROM and non PPROM twins. The GA at PPROM and latency period were both significantly associated with discharge without severe or moderate-severe neonatal morbidity. Pregnancy complications and 5-min Apgar score < 7 increased severe neonatal morbidity. As GA at PPROM increased, the risk of adverse perinatal outcomes decreased. GA at PPROM and latency period were significantly associated with discharge without severe or moderate-severe neonatal morbidity.Shuwei ZhouYajun YangXiaoYan ZhangXiaoling MuQuan QuanQimei ZhongLingwei MeiLan WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuwei Zhou Yajun Yang XiaoYan Zhang Xiaoling Mu Quan Quan Qimei Zhong Lingwei Mei Lan Wang Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation
description	Abstract To describe the perinatal outcomes of twin pregnancies with preterm premature rupture of membranes (PPROM) before 34 weeks’ gestation and identify factors associated with discharge without severe or moderate-severe neonatal morbidity. This study was conducted as a retrospective analysis of twin pregnancies with PPROM occurring at 24 0/7 to 33 6/7 weeks’ gestation. Perinatal outcomes were assessed by gestational age (GA) at PPROM and compared between PPROM and non PPROM twins. Factors associated with discharge without severe or moderate-severe neonatal morbidity were identified using logistic regression analysis. Of the 180 pregnancies (360 foetuses), only 17 (9.4%) women remained pregnant 7 days after PPROM. There were 10 (2.8%) cases of prenatal or neonatal death; 303 (84.2%) and 177 (49.2%) neonates were discharged without severe or moderate-severe morbidity, respectively. As GA at PPROM increased, the adverse obstetric and neonatal outcomes decreased, especially after 32 weeks. There was no significant difference in general neonatal outcomes between PPROM and non PPROM twins. The GA at PPROM and latency period were both significantly associated with discharge without severe or moderate-severe neonatal morbidity. Pregnancy complications and 5-min Apgar score < 7 increased severe neonatal morbidity. As GA at PPROM increased, the risk of adverse perinatal outcomes decreased. GA at PPROM and latency period were significantly associated with discharge without severe or moderate-severe neonatal morbidity.
format	article
author	Shuwei Zhou Yajun Yang XiaoYan Zhang Xiaoling Mu Quan Quan Qimei Zhong Lingwei Mei Lan Wang
author_facet	Shuwei Zhou Yajun Yang XiaoYan Zhang Xiaoling Mu Quan Quan Qimei Zhong Lingwei Mei Lan Wang
author_sort	Shuwei Zhou
title	Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation
title_short	Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation
title_full	Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation
title_fullStr	Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation
title_full_unstemmed	Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation
title_sort	perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c21ea009629d47ecbfe189cd57eabc07
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Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation

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