Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia

Abstract Functional dyspepsia (FD) is one of the most prevalent functional gastrointestinal disorders, and more and more multicomponent drugs represented by traditional Chinese medicines have provided a favorable therapeutic effect in its treatment. However, their precise localization in the clinic,...

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Autores principales:	Junying Wei, Qiong Man, Feifei Guo, Minghua Xian, Tingting Wang, Chunyu Tang, Yi Zhang, Defeng Li, Daifeng Tang, Hongjun Yang, Luqi Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c21f7d59e78947b6bab86aeebb33afe6
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spelling	oai:doaj.org-article:c21f7d59e78947b6bab86aeebb33afe62021-12-02T15:08:21ZPrecise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia10.1038/s41598-019-47300-72045-2322https://doaj.org/article/c21f7d59e78947b6bab86aeebb33afe62019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-47300-7https://doaj.org/toc/2045-2322Abstract Functional dyspepsia (FD) is one of the most prevalent functional gastrointestinal disorders, and more and more multicomponent drugs represented by traditional Chinese medicines have provided a favorable therapeutic effect in its treatment. However, their precise localization in the clinic, as well as corresponding mechanism, is ambiguous, thus hindering their widespread use. To meet this requirement, a precise and systematic approach based on a restriction of special disease-related molecules and the following network pharmacology analysis was developed and applied to a multicomponent conventional drug, XiaoErFuPi (XEFP) granules. Experimental verification of the results indicates that this approach can facilitate the prediction, and the precise and systematic efficacy of XEFP could be easily revealed, which shows that XEFP has an advantage over the positive control drug on lactate, gastrin, interleukin 4 and calcitonin gene-related peptide. Moreover, by the proteomics analysis, its superposition of multi-target effects was revealed and a new candidate target for the treatment of FD, striatin, was obtained and verified. This study provides a practicable precise approach for the investigation of the efficacy of multicomponent drugs against FD and offers a promising alternative for the systematical management of FD.Junying WeiQiong ManFeifei GuoMinghua XianTingting WangChunyu TangYi ZhangDefeng LiDaifeng TangHongjun YangLuqi HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Junying Wei Qiong Man Feifei Guo Minghua Xian Tingting Wang Chunyu Tang Yi Zhang Defeng Li Daifeng Tang Hongjun Yang Luqi Huang Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia
description	Abstract Functional dyspepsia (FD) is one of the most prevalent functional gastrointestinal disorders, and more and more multicomponent drugs represented by traditional Chinese medicines have provided a favorable therapeutic effect in its treatment. However, their precise localization in the clinic, as well as corresponding mechanism, is ambiguous, thus hindering their widespread use. To meet this requirement, a precise and systematic approach based on a restriction of special disease-related molecules and the following network pharmacology analysis was developed and applied to a multicomponent conventional drug, XiaoErFuPi (XEFP) granules. Experimental verification of the results indicates that this approach can facilitate the prediction, and the precise and systematic efficacy of XEFP could be easily revealed, which shows that XEFP has an advantage over the positive control drug on lactate, gastrin, interleukin 4 and calcitonin gene-related peptide. Moreover, by the proteomics analysis, its superposition of multi-target effects was revealed and a new candidate target for the treatment of FD, striatin, was obtained and verified. This study provides a practicable precise approach for the investigation of the efficacy of multicomponent drugs against FD and offers a promising alternative for the systematical management of FD.
format	article
author	Junying Wei Qiong Man Feifei Guo Minghua Xian Tingting Wang Chunyu Tang Yi Zhang Defeng Li Daifeng Tang Hongjun Yang Luqi Huang
author_facet	Junying Wei Qiong Man Feifei Guo Minghua Xian Tingting Wang Chunyu Tang Yi Zhang Defeng Li Daifeng Tang Hongjun Yang Luqi Huang
author_sort	Junying Wei
title	Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia
title_short	Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia
title_full	Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia
title_fullStr	Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia
title_full_unstemmed	Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia
title_sort	precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c21f7d59e78947b6bab86aeebb33afe6
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Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia

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