Screening for mild cognitive impairment in patients with cardiovascular risk factors

Teodora Yaneva-Sirakova,1 Latchezar Traykov,2 Julia Petrova,2 Ivan Gruev,3 Dobrin Vassilev1 1Department of Internal Medicine, Cardiology Clinic, 2Department of Neurology, Neurology Clinic, Medical University Sofia, 3Cardiology Clinic, National Transport Hospital “Tsar Boris III”...

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Autores principales:	Yaneva-Sirakova T, Traykov L, Petrova J, Gruev I, Vassilev D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	arterial hypertension cardio-vascular risk factors mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c21f9c89624a48cfbfa4d89799c45158
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spelling	oai:doaj.org-article:c21f9c89624a48cfbfa4d89799c451582021-12-02T08:15:47ZScreening for mild cognitive impairment in patients with cardiovascular risk factors1178-2021https://doaj.org/article/c21f9c89624a48cfbfa4d89799c451582017-12-01T00:00:00Zhttps://www.dovepress.com/screening-for-mild-cognitive-impairment-in-patients-with-cardiovascula-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Teodora Yaneva-Sirakova,1 Latchezar Traykov,2 Julia Petrova,2 Ivan Gruev,3 Dobrin Vassilev1 1Department of Internal Medicine, Cardiology Clinic, 2Department of Neurology, Neurology Clinic, Medical University Sofia, 3Cardiology Clinic, National Transport Hospital “Tsar Boris III”, Sofia, Bulgaria Aim: Cardiovascular risk factors are also risk factors for cognitive impairment. They have cumulative effect in target organ damage. The precise correlation between cardiovascular risk factors and cognitive impairment, as well as assessing the extent to which they may affect cognitive functioning, is difficult to ascertain in everyday clinical practice. Quick, specific, and sensitive neuropsychological tests may be useful in screening for, and the prophylaxis of, target organ damage in hypertensive patients.Methods: We gathered full anamnesis, performed physical examination, laboratory screening and echocardiography. These variables were observed at office and home for all patients, For half of the patients, 24-hour ambulatory blood pressure monitoring and neuropsychological testing using Montreal Cognitive Assessment (MoCA), Mini Mental State Examination (MMSE), Geriatric Depression Scale, and the 4-instrumental activities of daily living scale were undertaken.Results: For a period of 2 years, 931 patients were included after applying the inclusion and exclusion criteria. The mean age was 65.90±10.00 years. Two hundred and sixty three patients (85 [32.32%] males and 178 [67.68%] females) were reevaluated after a mean follow-up period of 12 months (6–20 months). The mean results of MoCA and MMSE were significantly lower (p<0.05) in the group of patients with poorly controlled blood pressure and cardiovascular risk factors. There was mild to intermediate negative correlation between Systematic Coronary Risk Evaluation (SCORE) and the neuropsychological tests’ results.Conclusion: Cardiovascular risk factors play an important role for the development of cognitive impairment in the eastern European population because of their high frequency and interaction. The use of easily applicable neuropsychological tests in everyday clinical practice of specialties other than neurology may help in stratifying the risk for development and progression of mild cognitive impairment in this high-risk group. Keywords: arterial hypertension, cardiovascular risk factors, mild cognitive impairment, MoCA, pulse pressure, systolic pressureYaneva-Sirakova TTraykov LPetrova JGruev IVassilev DDove Medical Pressarticlearterial hypertensioncardio-vascular risk factorsmild cognitive impairmentNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2925-2934 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	arterial hypertension cardio-vascular risk factors mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	arterial hypertension cardio-vascular risk factors mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yaneva-Sirakova T Traykov L Petrova J Gruev I Vassilev D Screening for mild cognitive impairment in patients with cardiovascular risk factors
description	Teodora Yaneva-Sirakova,1 Latchezar Traykov,2 Julia Petrova,2 Ivan Gruev,3 Dobrin Vassilev1 1Department of Internal Medicine, Cardiology Clinic, 2Department of Neurology, Neurology Clinic, Medical University Sofia, 3Cardiology Clinic, National Transport Hospital “Tsar Boris III”, Sofia, Bulgaria Aim: Cardiovascular risk factors are also risk factors for cognitive impairment. They have cumulative effect in target organ damage. The precise correlation between cardiovascular risk factors and cognitive impairment, as well as assessing the extent to which they may affect cognitive functioning, is difficult to ascertain in everyday clinical practice. Quick, specific, and sensitive neuropsychological tests may be useful in screening for, and the prophylaxis of, target organ damage in hypertensive patients.Methods: We gathered full anamnesis, performed physical examination, laboratory screening and echocardiography. These variables were observed at office and home for all patients, For half of the patients, 24-hour ambulatory blood pressure monitoring and neuropsychological testing using Montreal Cognitive Assessment (MoCA), Mini Mental State Examination (MMSE), Geriatric Depression Scale, and the 4-instrumental activities of daily living scale were undertaken.Results: For a period of 2 years, 931 patients were included after applying the inclusion and exclusion criteria. The mean age was 65.90±10.00 years. Two hundred and sixty three patients (85 [32.32%] males and 178 [67.68%] females) were reevaluated after a mean follow-up period of 12 months (6–20 months). The mean results of MoCA and MMSE were significantly lower (p<0.05) in the group of patients with poorly controlled blood pressure and cardiovascular risk factors. There was mild to intermediate negative correlation between Systematic Coronary Risk Evaluation (SCORE) and the neuropsychological tests’ results.Conclusion: Cardiovascular risk factors play an important role for the development of cognitive impairment in the eastern European population because of their high frequency and interaction. The use of easily applicable neuropsychological tests in everyday clinical practice of specialties other than neurology may help in stratifying the risk for development and progression of mild cognitive impairment in this high-risk group. Keywords: arterial hypertension, cardiovascular risk factors, mild cognitive impairment, MoCA, pulse pressure, systolic pressure
format	article
author	Yaneva-Sirakova T Traykov L Petrova J Gruev I Vassilev D
author_facet	Yaneva-Sirakova T Traykov L Petrova J Gruev I Vassilev D
author_sort	Yaneva-Sirakova T
title	Screening for mild cognitive impairment in patients with cardiovascular risk factors
title_short	Screening for mild cognitive impairment in patients with cardiovascular risk factors
title_full	Screening for mild cognitive impairment in patients with cardiovascular risk factors
title_fullStr	Screening for mild cognitive impairment in patients with cardiovascular risk factors
title_full_unstemmed	Screening for mild cognitive impairment in patients with cardiovascular risk factors
title_sort	screening for mild cognitive impairment in patients with cardiovascular risk factors
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/c21f9c89624a48cfbfa4d89799c45158
work_keys_str_mv	AT yanevasirakovat screeningformildcognitiveimpairmentinpatientswithcardiovascularriskfactors AT traykovl screeningformildcognitiveimpairmentinpatientswithcardiovascularriskfactors AT petrovaj screeningformildcognitiveimpairmentinpatientswithcardiovascularriskfactors AT gruevi screeningformildcognitiveimpairmentinpatientswithcardiovascularriskfactors AT vassilevd screeningformildcognitiveimpairmentinpatientswithcardiovascularriskfactors
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Screening for mild cognitive impairment in patients with cardiovascular risk factors

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