Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis

Aurora B activation at the centromere is critical for faithful chromosome segregation in mammals. Here the authors show that Aurora B-mediated phosphorylation of histone H2AX at serine 121 is essential for Aurora B auto-activation circuitry at centromeres, ensuring proper chromosome segregation.

Guardado en:

Detalles Bibliográficos
Autores principales:	Midori Shimada, Takahiro Goshima, Hiromi Matsuo, Yoshikazu Johmura, Mayumi Haruta, Kazuhiro Murata, Hiromitsu Tanaka, Masahito Ikawa, Keiko Nakanishi, Makoto Nakanishi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c21fc871e4a34ceb96dff2ba52d70bae
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c21fc871e4a34ceb96dff2ba52d70bae
record_format	dspace
spelling	oai:doaj.org-article:c21fc871e4a34ceb96dff2ba52d70bae2021-12-02T17:32:04ZEssential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis10.1038/ncomms120592041-1723https://doaj.org/article/c21fc871e4a34ceb96dff2ba52d70bae2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12059https://doaj.org/toc/2041-1723Aurora B activation at the centromere is critical for faithful chromosome segregation in mammals. Here the authors show that Aurora B-mediated phosphorylation of histone H2AX at serine 121 is essential for Aurora B auto-activation circuitry at centromeres, ensuring proper chromosome segregation.Midori ShimadaTakahiro GoshimaHiromi MatsuoYoshikazu JohmuraMayumi HarutaKazuhiro MurataHiromitsu TanakaMasahito IkawaKeiko NakanishiMakoto NakanishiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Midori Shimada Takahiro Goshima Hiromi Matsuo Yoshikazu Johmura Mayumi Haruta Kazuhiro Murata Hiromitsu Tanaka Masahito Ikawa Keiko Nakanishi Makoto Nakanishi Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis
description	Aurora B activation at the centromere is critical for faithful chromosome segregation in mammals. Here the authors show that Aurora B-mediated phosphorylation of histone H2AX at serine 121 is essential for Aurora B auto-activation circuitry at centromeres, ensuring proper chromosome segregation.
format	article
author	Midori Shimada Takahiro Goshima Hiromi Matsuo Yoshikazu Johmura Mayumi Haruta Kazuhiro Murata Hiromitsu Tanaka Masahito Ikawa Keiko Nakanishi Makoto Nakanishi
author_facet	Midori Shimada Takahiro Goshima Hiromi Matsuo Yoshikazu Johmura Mayumi Haruta Kazuhiro Murata Hiromitsu Tanaka Masahito Ikawa Keiko Nakanishi Makoto Nakanishi
author_sort	Midori Shimada
title	Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis
title_short	Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis
title_full	Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis
title_fullStr	Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis
title_full_unstemmed	Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis
title_sort	essential role of autoactivation circuitry on aurora b-mediated h2ax-ps121 in mitosis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c21fc871e4a34ceb96dff2ba52d70bae
work_keys_str_mv	AT midorishimada essentialroleofautoactivationcircuitryonaurorabmediatedh2axps121inmitosis AT takahirogoshima essentialroleofautoactivationcircuitryonaurorabmediatedh2axps121inmitosis AT hiromimatsuo essentialroleofautoactivationcircuitryonaurorabmediatedh2axps121inmitosis AT yoshikazujohmura essentialroleofautoactivationcircuitryonaurorabmediatedh2axps121inmitosis AT mayumiharuta essentialroleofautoactivationcircuitryonaurorabmediatedh2axps121inmitosis AT kazuhiromurata essentialroleofautoactivationcircuitryonaurorabmediatedh2axps121inmitosis AT hiromitsutanaka essentialroleofautoactivationcircuitryonaurorabmediatedh2axps121inmitosis AT masahitoikawa essentialroleofautoactivationcircuitryonaurorabmediatedh2axps121inmitosis AT keikonakanishi essentialroleofautoactivationcircuitryonaurorabmediatedh2axps121inmitosis AT makotonakanishi essentialroleofautoactivationcircuitryonaurorabmediatedh2axps121inmitosis
_version_	1718380454166396928

Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis

Ejemplares similares