The importance of age in compositional and functional profiling of the human intestinal microbiome.

The intestinal microbiome plays a central role in human health and disease. While its composition is relatively stable throughout adulthood, the microbial balance starts to decrease in later life stages. Thus, in order to maintain a good quality of life, including the prevention of age-associated di...

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Autores principales:	Elio L Herzog, Melania Wäfler, Irene Keller, Sebastian Wolf, Martin S Zinkernagel, Denise C Zysset-Burri
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c22266a91b474385a0a158f420d6cafe
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spelling	oai:doaj.org-article:c22266a91b474385a0a158f420d6cafe2021-12-02T20:16:50ZThe importance of age in compositional and functional profiling of the human intestinal microbiome.1932-620310.1371/journal.pone.0258505https://doaj.org/article/c22266a91b474385a0a158f420d6cafe2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258505https://doaj.org/toc/1932-6203The intestinal microbiome plays a central role in human health and disease. While its composition is relatively stable throughout adulthood, the microbial balance starts to decrease in later life stages. Thus, in order to maintain a good quality of life, including the prevention of age-associated diseases in the elderly, it is important to understand the dynamics of the intestinal microbiome. In this study, stool samples of 278 participants were sequenced by whole metagenome shotgun sequencing and their taxonomic and functional profiles characterized. The two age groups, below65 and above65, could be separated based on taxonomic and associated functional features using Multivariate Association of Linear Models. In a second approach, through machine learning, biomarkers connecting the intestinal microbiome with age were identified. These results reflect the importance to select age-matched study groups for unbiased metagenomic data analysis and the possibility to generate robust data by applying independent algorithms for data analysis. Furthermore, since the intestinal microbiome can be modulated by antibiotics and probiotics, the data of this study may have implications on preventive strategies of age-associated degradation processes and diseases by microbiome-altering interventions.Elio L HerzogMelania WäflerIrene KellerSebastian WolfMartin S ZinkernagelDenise C Zysset-BurriPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258505 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elio L Herzog Melania Wäfler Irene Keller Sebastian Wolf Martin S Zinkernagel Denise C Zysset-Burri The importance of age in compositional and functional profiling of the human intestinal microbiome.
description	The intestinal microbiome plays a central role in human health and disease. While its composition is relatively stable throughout adulthood, the microbial balance starts to decrease in later life stages. Thus, in order to maintain a good quality of life, including the prevention of age-associated diseases in the elderly, it is important to understand the dynamics of the intestinal microbiome. In this study, stool samples of 278 participants were sequenced by whole metagenome shotgun sequencing and their taxonomic and functional profiles characterized. The two age groups, below65 and above65, could be separated based on taxonomic and associated functional features using Multivariate Association of Linear Models. In a second approach, through machine learning, biomarkers connecting the intestinal microbiome with age were identified. These results reflect the importance to select age-matched study groups for unbiased metagenomic data analysis and the possibility to generate robust data by applying independent algorithms for data analysis. Furthermore, since the intestinal microbiome can be modulated by antibiotics and probiotics, the data of this study may have implications on preventive strategies of age-associated degradation processes and diseases by microbiome-altering interventions.
format	article
author	Elio L Herzog Melania Wäfler Irene Keller Sebastian Wolf Martin S Zinkernagel Denise C Zysset-Burri
author_facet	Elio L Herzog Melania Wäfler Irene Keller Sebastian Wolf Martin S Zinkernagel Denise C Zysset-Burri
author_sort	Elio L Herzog
title	The importance of age in compositional and functional profiling of the human intestinal microbiome.
title_short	The importance of age in compositional and functional profiling of the human intestinal microbiome.
title_full	The importance of age in compositional and functional profiling of the human intestinal microbiome.
title_fullStr	The importance of age in compositional and functional profiling of the human intestinal microbiome.
title_full_unstemmed	The importance of age in compositional and functional profiling of the human intestinal microbiome.
title_sort	importance of age in compositional and functional profiling of the human intestinal microbiome.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c22266a91b474385a0a158f420d6cafe
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The importance of age in compositional and functional profiling of the human intestinal microbiome.

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