Epigenetic Heterogeneity in Friedreich Ataxia Underlies Variable FXN Reactivation

Friedreich ataxia (FRDA) is typically caused by homozygosity for an expanded GAA triplet-repeat in intron 1 of the FXN gene. The expanded repeat induces repressive histone changes and DNA hypermethylation, which result in epigenetic silencing and FXN transcriptional deficiency. A class I histone dea...

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Autores principales: Layne N. Rodden, Kaitlyn M. Gilliam, Christina Lam, David R. Lynch, Sanjay I. Bidichandani
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/c223ce88b32f4ae1b24813a1b5f86a2b
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