Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration

Abstract As the proportion of long-term survivors after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is on the rise, it is essential to consider the significance of quality of life (QOL), including reintegration with society (returning to school or work). This retrospective cohort...

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Autores principales: Ryota Hamada, Yasuyuki Arai, Tadakazu Kondo, Kazuhiro Harada, Masanobu Murao, Junsuke Miyasaka, Michiko Yoshida, Honami Yonezawa, Manabu Nankaku, Sayako Ouchi, Wakako Kitakubo, Tomoko Wadayama, Junya Kanda, Akifumi Takaori-Kondo, Ryosuke Ikeguchi, Shuichi Matsuda
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:c223e7458b4a492f99643425517a3c4b2021-12-02T18:17:54ZHigher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration10.1038/s41598-021-86744-82045-2322https://doaj.org/article/c223e7458b4a492f99643425517a3c4b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86744-8https://doaj.org/toc/2045-2322Abstract As the proportion of long-term survivors after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is on the rise, it is essential to consider the significance of quality of life (QOL), including reintegration with society (returning to school or work). This retrospective cohort study aims to illustrate the precise epidemiology of social reintegration later after allo-HSCT and determine its predictive indicators. We enrolled 56 patients, and 40 patients (71%) attained social reintegration at 2 years post-HSCT. Reintegration failure markedly correlated with an inferior performance status and concurrent chronic graft-versus-host disease. In non-reintegrated patients, the physical function at discharge measured by the 6-min walking distance (6MWD) was markedly decreased. On the multivariate risk analyses, sex (female; odds ratio (OR) 0.07; 95% confidence interval (CI) 0.01–0.54; p = 0.01), HCT-CI (≥ 2; OR 0.10; 95% CI 0.01–0.84; p = 0.03), and change in 6MWD (per 5% increase; OR 1.47; 95% CI 1.01–2.13; p = 0.04) were significant predictors of later social reintegration. This study suggests that a multidisciplinary strategy including rehabilitation is essential, especially in patients with poor predictive markers at an early phase, and we should consider suitable rehabilitation programs to prevent a decline in exercise tolerance and improve social reintegration and overall QOL in patients after allo-HSCT.Ryota HamadaYasuyuki AraiTadakazu KondoKazuhiro HaradaMasanobu MuraoJunsuke MiyasakaMichiko YoshidaHonami YonezawaManabu NankakuSayako OuchiWakako KitakuboTomoko WadayamaJunya KandaAkifumi Takaori-KondoRyosuke IkeguchiShuichi MatsudaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ryota Hamada
Yasuyuki Arai
Tadakazu Kondo
Kazuhiro Harada
Masanobu Murao
Junsuke Miyasaka
Michiko Yoshida
Honami Yonezawa
Manabu Nankaku
Sayako Ouchi
Wakako Kitakubo
Tomoko Wadayama
Junya Kanda
Akifumi Takaori-Kondo
Ryosuke Ikeguchi
Shuichi Matsuda
Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration
description Abstract As the proportion of long-term survivors after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is on the rise, it is essential to consider the significance of quality of life (QOL), including reintegration with society (returning to school or work). This retrospective cohort study aims to illustrate the precise epidemiology of social reintegration later after allo-HSCT and determine its predictive indicators. We enrolled 56 patients, and 40 patients (71%) attained social reintegration at 2 years post-HSCT. Reintegration failure markedly correlated with an inferior performance status and concurrent chronic graft-versus-host disease. In non-reintegrated patients, the physical function at discharge measured by the 6-min walking distance (6MWD) was markedly decreased. On the multivariate risk analyses, sex (female; odds ratio (OR) 0.07; 95% confidence interval (CI) 0.01–0.54; p = 0.01), HCT-CI (≥ 2; OR 0.10; 95% CI 0.01–0.84; p = 0.03), and change in 6MWD (per 5% increase; OR 1.47; 95% CI 1.01–2.13; p = 0.04) were significant predictors of later social reintegration. This study suggests that a multidisciplinary strategy including rehabilitation is essential, especially in patients with poor predictive markers at an early phase, and we should consider suitable rehabilitation programs to prevent a decline in exercise tolerance and improve social reintegration and overall QOL in patients after allo-HSCT.
format article
author Ryota Hamada
Yasuyuki Arai
Tadakazu Kondo
Kazuhiro Harada
Masanobu Murao
Junsuke Miyasaka
Michiko Yoshida
Honami Yonezawa
Manabu Nankaku
Sayako Ouchi
Wakako Kitakubo
Tomoko Wadayama
Junya Kanda
Akifumi Takaori-Kondo
Ryosuke Ikeguchi
Shuichi Matsuda
author_facet Ryota Hamada
Yasuyuki Arai
Tadakazu Kondo
Kazuhiro Harada
Masanobu Murao
Junsuke Miyasaka
Michiko Yoshida
Honami Yonezawa
Manabu Nankaku
Sayako Ouchi
Wakako Kitakubo
Tomoko Wadayama
Junya Kanda
Akifumi Takaori-Kondo
Ryosuke Ikeguchi
Shuichi Matsuda
author_sort Ryota Hamada
title Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration
title_short Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration
title_full Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration
title_fullStr Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration
title_full_unstemmed Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration
title_sort higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c223e7458b4a492f99643425517a3c4b
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