Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells

Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells

The c-MYC oncoprotein has many targets whose actions are not fully understood including TFAP4/AP4. Here, the authors show in a mouse model of inherited colorectal cancer that deletion of AP4 decreased the frequency of c-MYC-driven intestinal adenomas, and reveal Ap4 as a mediator of adenoma initiati...

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Autores principales: Stephanie Jaeckel, Markus Kaller, Rene Jackstadt, Ursula Götz, Susanna Müller, Sophie Boos, David Horst, Peter Jung, Heiko Hermeking
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/c22477ac99a148f3b0a8d972d65afea8
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