Feasibility of a Reusable Radiochromic Dosimeter

The current practice for patient-specific quality assurance (QA) uses ion chambers or diode arrays primarily because of their ease of use and reliability. A standard routine compares the dose distribution measured in a phantom with the dose distribution calculated by the treatment planning system fo...

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Autores principales:	Joseph R. Newton, Maxwell Recht, Joseph A. Hauger, Gabriel Segarra, Chase Inglett, Pedro A. Romo, John Adamovics
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	radiation therapy verification dosimetry radiochromic reusability Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c226b5bc503b4bff8eea1ba69458e3d8
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spelling	oai:doaj.org-article:c226b5bc503b4bff8eea1ba69458e3d82021-11-11T15:00:27ZFeasibility of a Reusable Radiochromic Dosimeter10.3390/app112199062076-3417https://doaj.org/article/c226b5bc503b4bff8eea1ba69458e3d82021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/9906https://doaj.org/toc/2076-3417The current practice for patient-specific quality assurance (QA) uses ion chambers or diode arrays primarily because of their ease of use and reliability. A standard routine compares the dose distribution measured in a phantom with the dose distribution calculated by the treatment planning system for the same experimental conditions. For the particular problems encountered in the treatment planning of complex radiotherapy techniques, such as small fields/segments and dynamic delivery systems, additional tests are required to verify the accuracy of dose calculations. The dose distribution verification should be throughout the total 3D dose distribution for a high dose gradient in a small, irradiated volume, instead of the standard practice of one to several planes with 2D radiochromic (GAFChromic) film. To address this issue, we have developed a 3D radiochromic dosimeter that improves the rigor of current QA techniques by providing high-resolution, complete 3D verification for a wide range of clinical applications. The dosimeter is composed of polyurethane, a radical initiator, and a leuco dye, which is radiolytically oxidized to a dye absorbing at 633 nm. Since this chemical dosimeter is single-use, it represents a significant expense. The purpose of this research is to develop a cost-effective reusable dosimeter formulation. Based on prior reusability studies, three promising dosimeter formulations were studied using small volume optical cuvettes and irradiated to known clinically relevant doses of 0.5–10 Gy. After irradiation, the change in optical density was measured in a spectrophotometer. All three formulations retained linearity of optical density response to radiation upon re-irradiations. However, only one formulation retained dose sensitivity upon at least five re-irradiations, making it ideal for further evaluation as a 3D dosimeter.Joseph R. NewtonMaxwell RechtJoseph A. HaugerGabriel SegarraChase InglettPedro A. RomoJohn AdamovicsMDPI AGarticleradiation therapy verificationdosimetryradiochromicreusabilityTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 9906, p 9906 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiation therapy verification dosimetry radiochromic reusability Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	radiation therapy verification dosimetry radiochromic reusability Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Joseph R. Newton Maxwell Recht Joseph A. Hauger Gabriel Segarra Chase Inglett Pedro A. Romo John Adamovics Feasibility of a Reusable Radiochromic Dosimeter
description	The current practice for patient-specific quality assurance (QA) uses ion chambers or diode arrays primarily because of their ease of use and reliability. A standard routine compares the dose distribution measured in a phantom with the dose distribution calculated by the treatment planning system for the same experimental conditions. For the particular problems encountered in the treatment planning of complex radiotherapy techniques, such as small fields/segments and dynamic delivery systems, additional tests are required to verify the accuracy of dose calculations. The dose distribution verification should be throughout the total 3D dose distribution for a high dose gradient in a small, irradiated volume, instead of the standard practice of one to several planes with 2D radiochromic (GAFChromic) film. To address this issue, we have developed a 3D radiochromic dosimeter that improves the rigor of current QA techniques by providing high-resolution, complete 3D verification for a wide range of clinical applications. The dosimeter is composed of polyurethane, a radical initiator, and a leuco dye, which is radiolytically oxidized to a dye absorbing at 633 nm. Since this chemical dosimeter is single-use, it represents a significant expense. The purpose of this research is to develop a cost-effective reusable dosimeter formulation. Based on prior reusability studies, three promising dosimeter formulations were studied using small volume optical cuvettes and irradiated to known clinically relevant doses of 0.5–10 Gy. After irradiation, the change in optical density was measured in a spectrophotometer. All three formulations retained linearity of optical density response to radiation upon re-irradiations. However, only one formulation retained dose sensitivity upon at least five re-irradiations, making it ideal for further evaluation as a 3D dosimeter.
format	article
author	Joseph R. Newton Maxwell Recht Joseph A. Hauger Gabriel Segarra Chase Inglett Pedro A. Romo John Adamovics
author_facet	Joseph R. Newton Maxwell Recht Joseph A. Hauger Gabriel Segarra Chase Inglett Pedro A. Romo John Adamovics
author_sort	Joseph R. Newton
title	Feasibility of a Reusable Radiochromic Dosimeter
title_short	Feasibility of a Reusable Radiochromic Dosimeter
title_full	Feasibility of a Reusable Radiochromic Dosimeter
title_fullStr	Feasibility of a Reusable Radiochromic Dosimeter
title_full_unstemmed	Feasibility of a Reusable Radiochromic Dosimeter
title_sort	feasibility of a reusable radiochromic dosimeter
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c226b5bc503b4bff8eea1ba69458e3d8
work_keys_str_mv	AT josephrnewton feasibilityofareusableradiochromicdosimeter AT maxwellrecht feasibilityofareusableradiochromicdosimeter AT josephahauger feasibilityofareusableradiochromicdosimeter AT gabrielsegarra feasibilityofareusableradiochromicdosimeter AT chaseinglett feasibilityofareusableradiochromicdosimeter AT pedroaromo feasibilityofareusableradiochromicdosimeter AT johnadamovics feasibilityofareusableradiochromicdosimeter
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Feasibility of a Reusable Radiochromic Dosimeter

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