Effectiveness of seasonal influenza vaccines against influenza-associated illnesses among US military personnel in 2010-11: a case-control approach.

<h4>Introduction</h4>Following the 2009 influenza A/H1N1 (pH1N1) pandemic, both seasonal and pH1N1 viruses circulated in the US during the 2010-2011 influenza season; influenza vaccine effectiveness (VE) may vary between live attenuated (LAIV) and trivalent inactivated (TIV) vaccines as...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Angelia A Eick-Cost, Katie J Tastad, Alicia C Guerrero, Matthew C Johns, Seung-Eun Lee, Victor H Macintosh, Ronald L Burke, David L Blazes, Kevin L Russell, Jose L Sanchez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c22811854fd24ee79e085c484065cfd7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c22811854fd24ee79e085c484065cfd7
record_format	dspace
spelling	oai:doaj.org-article:c22811854fd24ee79e085c484065cfd72021-11-18T07:10:18ZEffectiveness of seasonal influenza vaccines against influenza-associated illnesses among US military personnel in 2010-11: a case-control approach.1932-620310.1371/journal.pone.0041435https://doaj.org/article/c22811854fd24ee79e085c484065cfd72012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22859985/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Following the 2009 influenza A/H1N1 (pH1N1) pandemic, both seasonal and pH1N1 viruses circulated in the US during the 2010-2011 influenza season; influenza vaccine effectiveness (VE) may vary between live attenuated (LAIV) and trivalent inactivated (TIV) vaccines as well as by virus subtype.<h4>Materials and methods</h4>Vaccine type and virus subtype-specific VE were determined for US military active component personnel for the period of September 1, 2010 through April 30, 2011. Laboratory-confirmed influenza-related medical encounters were compared to matched individuals with a non-respiratory illness (healthy controls), and unmatched individuals who experienced a non-influenza respiratory illness (test-negative controls). Odds ratios (OR) and VE estimates were calculated overall, by vaccine type and influenza subtype.<h4>Results</h4>A total of 603 influenza cases were identified. Overall VE was relatively low and similar regardless of whether healthy controls (VE = 26%, 95% CI: -1 to 45) or test-negative controls (VE = 29%, 95% CI: -6 to 53) were used as comparison groups. Using test-negative controls, vaccine type-specific VE was found to be higher for TIV (53%, 95% CI: 25 to 71) than for LAIV (VE = -13%, 95% CI: -77 to 27). Influenza subtype-specific analyses revealed moderate protection against A/H3 (VE = 58%, 95% CI: 21 to 78), but not against A/H1 (VE = -38%, 95% CI: -211 to 39) or B (VE = 34%, 95% CI: -122 to 80).<h4>Conclusion</h4>Overall, a low level of protection against clinically-apparent, laboratory-confirmed, influenza was found for the 2010-11 seasonal influenza vaccines. TIV immunization was associated with higher protection than LAIV, however, no protection against A/H1 was noted, despite inclusion of a pandemic influenza strain as a vaccine component for two consecutive years. Vaccine virus mismatch or lower immunogenicity may have contributed to these findings and deserve further examination in controlled studies. Continued assessment of VE in military personnel is essential in order to better inform vaccination policy decisions.Angelia A Eick-CostKatie J TastadAlicia C GuerreroMatthew C JohnsSeung-Eun LeeVictor H MacintoshRonald L BurkeDavid L BlazesKevin L RussellJose L SanchezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41435 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angelia A Eick-Cost Katie J Tastad Alicia C Guerrero Matthew C Johns Seung-Eun Lee Victor H Macintosh Ronald L Burke David L Blazes Kevin L Russell Jose L Sanchez Effectiveness of seasonal influenza vaccines against influenza-associated illnesses among US military personnel in 2010-11: a case-control approach.
description	<h4>Introduction</h4>Following the 2009 influenza A/H1N1 (pH1N1) pandemic, both seasonal and pH1N1 viruses circulated in the US during the 2010-2011 influenza season; influenza vaccine effectiveness (VE) may vary between live attenuated (LAIV) and trivalent inactivated (TIV) vaccines as well as by virus subtype.<h4>Materials and methods</h4>Vaccine type and virus subtype-specific VE were determined for US military active component personnel for the period of September 1, 2010 through April 30, 2011. Laboratory-confirmed influenza-related medical encounters were compared to matched individuals with a non-respiratory illness (healthy controls), and unmatched individuals who experienced a non-influenza respiratory illness (test-negative controls). Odds ratios (OR) and VE estimates were calculated overall, by vaccine type and influenza subtype.<h4>Results</h4>A total of 603 influenza cases were identified. Overall VE was relatively low and similar regardless of whether healthy controls (VE = 26%, 95% CI: -1 to 45) or test-negative controls (VE = 29%, 95% CI: -6 to 53) were used as comparison groups. Using test-negative controls, vaccine type-specific VE was found to be higher for TIV (53%, 95% CI: 25 to 71) than for LAIV (VE = -13%, 95% CI: -77 to 27). Influenza subtype-specific analyses revealed moderate protection against A/H3 (VE = 58%, 95% CI: 21 to 78), but not against A/H1 (VE = -38%, 95% CI: -211 to 39) or B (VE = 34%, 95% CI: -122 to 80).<h4>Conclusion</h4>Overall, a low level of protection against clinically-apparent, laboratory-confirmed, influenza was found for the 2010-11 seasonal influenza vaccines. TIV immunization was associated with higher protection than LAIV, however, no protection against A/H1 was noted, despite inclusion of a pandemic influenza strain as a vaccine component for two consecutive years. Vaccine virus mismatch or lower immunogenicity may have contributed to these findings and deserve further examination in controlled studies. Continued assessment of VE in military personnel is essential in order to better inform vaccination policy decisions.
format	article
author	Angelia A Eick-Cost Katie J Tastad Alicia C Guerrero Matthew C Johns Seung-Eun Lee Victor H Macintosh Ronald L Burke David L Blazes Kevin L Russell Jose L Sanchez
author_facet	Angelia A Eick-Cost Katie J Tastad Alicia C Guerrero Matthew C Johns Seung-Eun Lee Victor H Macintosh Ronald L Burke David L Blazes Kevin L Russell Jose L Sanchez
author_sort	Angelia A Eick-Cost
title	Effectiveness of seasonal influenza vaccines against influenza-associated illnesses among US military personnel in 2010-11: a case-control approach.
title_short	Effectiveness of seasonal influenza vaccines against influenza-associated illnesses among US military personnel in 2010-11: a case-control approach.
title_full	Effectiveness of seasonal influenza vaccines against influenza-associated illnesses among US military personnel in 2010-11: a case-control approach.
title_fullStr	Effectiveness of seasonal influenza vaccines against influenza-associated illnesses among US military personnel in 2010-11: a case-control approach.
title_full_unstemmed	Effectiveness of seasonal influenza vaccines against influenza-associated illnesses among US military personnel in 2010-11: a case-control approach.
title_sort	effectiveness of seasonal influenza vaccines against influenza-associated illnesses among us military personnel in 2010-11: a case-control approach.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c22811854fd24ee79e085c484065cfd7
work_keys_str_mv	AT angeliaaeickcost effectivenessofseasonalinfluenzavaccinesagainstinfluenzaassociatedillnessesamongusmilitarypersonnelin201011acasecontrolapproach AT katiejtastad effectivenessofseasonalinfluenzavaccinesagainstinfluenzaassociatedillnessesamongusmilitarypersonnelin201011acasecontrolapproach AT aliciacguerrero effectivenessofseasonalinfluenzavaccinesagainstinfluenzaassociatedillnessesamongusmilitarypersonnelin201011acasecontrolapproach AT matthewcjohns effectivenessofseasonalinfluenzavaccinesagainstinfluenzaassociatedillnessesamongusmilitarypersonnelin201011acasecontrolapproach AT seungeunlee effectivenessofseasonalinfluenzavaccinesagainstinfluenzaassociatedillnessesamongusmilitarypersonnelin201011acasecontrolapproach AT victorhmacintosh effectivenessofseasonalinfluenzavaccinesagainstinfluenzaassociatedillnessesamongusmilitarypersonnelin201011acasecontrolapproach AT ronaldlburke effectivenessofseasonalinfluenzavaccinesagainstinfluenzaassociatedillnessesamongusmilitarypersonnelin201011acasecontrolapproach AT davidlblazes effectivenessofseasonalinfluenzavaccinesagainstinfluenzaassociatedillnessesamongusmilitarypersonnelin201011acasecontrolapproach AT kevinlrussell effectivenessofseasonalinfluenzavaccinesagainstinfluenzaassociatedillnessesamongusmilitarypersonnelin201011acasecontrolapproach AT joselsanchez effectivenessofseasonalinfluenzavaccinesagainstinfluenzaassociatedillnessesamongusmilitarypersonnelin201011acasecontrolapproach
_version_	1718423879122157568

Effectiveness of seasonal influenza vaccines against influenza-associated illnesses among US military personnel in 2010-11: a case-control approach.

Ejemplares similares