Evaluation of malignant effusions using MR-based T1 mapping

Abstract Our aim was to investigate the diagnostic yield of rapid T1-mapping for the differentiation of malignant and non-malignant effusions in an ex-vivo set up. T1-mapping was performed with a fast modified Look-Locker inversion-recovery (MOLLI) acquisition and a combined turbo spin-echo and inve...

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Autores principales:	D. Kuetting, J. Luetkens, A. Faron, A. Isaak, U. Attenberger, C. C. Pieper, L. Meffert, C. Jansen, A. Sprinkart, F. Kütting
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c22911658a1c4d50984e3aa7dbcbb2d7
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spelling	oai:doaj.org-article:c22911658a1c4d50984e3aa7dbcbb2d72021-12-02T18:17:54ZEvaluation of malignant effusions using MR-based T1 mapping10.1038/s41598-021-86632-12045-2322https://doaj.org/article/c22911658a1c4d50984e3aa7dbcbb2d72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86632-1https://doaj.org/toc/2045-2322Abstract Our aim was to investigate the diagnostic yield of rapid T1-mapping for the differentiation of malignant and non-malignant effusions in an ex-vivo set up. T1-mapping was performed with a fast modified Look-Locker inversion-recovery (MOLLI) acquisition and a combined turbo spin-echo and inversion-recovery sequence (TMIX) as reference. A total of 13 titrated albumin-solutions as well as 48 samples (29 ascites/pleural effusions from patients with malignancy; 19 from patients without malignancy) were examined. Samples were classified as malignant-positive histology, malignant-negative histology and non-malignant negative histology. In phantom analysis both mapping techniques correlated with albumin-content (MOLLI: r = − 0.97, TMIX: r = − 0.98). MOLLI T1 relaxation times were shorter in malignancy-positive histology fluids (2237 ± 137 ms) than in malignancy-negative histology fluids (2423 ± 357 ms) as well as than in non-malignant-negative histology fluids (2651 ± 139 ms); post hoc test for all intergroup comparisons: < 0.05. ROC analysis for differentiation between malignant and non-malignant effusions (malignant positive histology vs. all other) showed an (AUC) of 0.89 (95% CI 0.77–0.96). T1 mapping allows for non-invasive differentiation of malignant and non-malignant effusions in an ex-vivo set up.D. KuettingJ. LuetkensA. FaronA. IsaakU. AttenbergerC. C. PieperL. MeffertC. JansenA. SprinkartF. KüttingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q D. Kuetting J. Luetkens A. Faron A. Isaak U. Attenberger C. C. Pieper L. Meffert C. Jansen A. Sprinkart F. Kütting Evaluation of malignant effusions using MR-based T1 mapping
description	Abstract Our aim was to investigate the diagnostic yield of rapid T1-mapping for the differentiation of malignant and non-malignant effusions in an ex-vivo set up. T1-mapping was performed with a fast modified Look-Locker inversion-recovery (MOLLI) acquisition and a combined turbo spin-echo and inversion-recovery sequence (TMIX) as reference. A total of 13 titrated albumin-solutions as well as 48 samples (29 ascites/pleural effusions from patients with malignancy; 19 from patients without malignancy) were examined. Samples were classified as malignant-positive histology, malignant-negative histology and non-malignant negative histology. In phantom analysis both mapping techniques correlated with albumin-content (MOLLI: r = − 0.97, TMIX: r = − 0.98). MOLLI T1 relaxation times were shorter in malignancy-positive histology fluids (2237 ± 137 ms) than in malignancy-negative histology fluids (2423 ± 357 ms) as well as than in non-malignant-negative histology fluids (2651 ± 139 ms); post hoc test for all intergroup comparisons: < 0.05. ROC analysis for differentiation between malignant and non-malignant effusions (malignant positive histology vs. all other) showed an (AUC) of 0.89 (95% CI 0.77–0.96). T1 mapping allows for non-invasive differentiation of malignant and non-malignant effusions in an ex-vivo set up.
format	article
author	D. Kuetting J. Luetkens A. Faron A. Isaak U. Attenberger C. C. Pieper L. Meffert C. Jansen A. Sprinkart F. Kütting
author_facet	D. Kuetting J. Luetkens A. Faron A. Isaak U. Attenberger C. C. Pieper L. Meffert C. Jansen A. Sprinkart F. Kütting
author_sort	D. Kuetting
title	Evaluation of malignant effusions using MR-based T1 mapping
title_short	Evaluation of malignant effusions using MR-based T1 mapping
title_full	Evaluation of malignant effusions using MR-based T1 mapping
title_fullStr	Evaluation of malignant effusions using MR-based T1 mapping
title_full_unstemmed	Evaluation of malignant effusions using MR-based T1 mapping
title_sort	evaluation of malignant effusions using mr-based t1 mapping
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c22911658a1c4d50984e3aa7dbcbb2d7
work_keys_str_mv	AT dkuetting evaluationofmalignanteffusionsusingmrbasedt1mapping AT jluetkens evaluationofmalignanteffusionsusingmrbasedt1mapping AT afaron evaluationofmalignanteffusionsusingmrbasedt1mapping AT aisaak evaluationofmalignanteffusionsusingmrbasedt1mapping AT uattenberger evaluationofmalignanteffusionsusingmrbasedt1mapping AT ccpieper evaluationofmalignanteffusionsusingmrbasedt1mapping AT lmeffert evaluationofmalignanteffusionsusingmrbasedt1mapping AT cjansen evaluationofmalignanteffusionsusingmrbasedt1mapping AT asprinkart evaluationofmalignanteffusionsusingmrbasedt1mapping AT fkutting evaluationofmalignanteffusionsusingmrbasedt1mapping
_version_	1718378297040044032

Evaluation of malignant effusions using MR-based T1 mapping

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