Sensitivity analysis of FDA´s benchmark nozzle regarding in vitro imperfections - Do we need asymmetric CFD benchmarks?

Modern technologies and methods such as computer simulation, so-called in silico methods, foster the development of medical devices. For accelerating the uptake of computer simulations and to increase credibility and reliability the U.S. Food and Drug Administration organized an inter-laboratory rou...

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Autores principales:	Stiehm Michael, Brandt-Wunderlich Christoph, Siewert Stefan, Schmitz Klaus-Peter, Grabow Niels, Goubergrits Leonid, Kühne Titus, Poon Eric K. W., Ooi Andrew, Barlis Peter
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	computational fluid dynamics (cfd) fda nozzle geometrical imperfection asymmetry Medicine R
Acceso en línea:	https://doaj.org/article/c22ccd023c4a4a319f78c935001a79e8
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spelling	oai:doaj.org-article:c22ccd023c4a4a319f78c935001a79e82021-12-05T14:10:42ZSensitivity analysis of FDA´s benchmark nozzle regarding in vitro imperfections - Do we need asymmetric CFD benchmarks?2364-550410.1515/cdbme-2020-3020https://doaj.org/article/c22ccd023c4a4a319f78c935001a79e82020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3020https://doaj.org/toc/2364-5504Modern technologies and methods such as computer simulation, so-called in silico methods, foster the development of medical devices. For accelerating the uptake of computer simulations and to increase credibility and reliability the U.S. Food and Drug Administration organized an inter-laboratory round robin study of a generic nozzle geometry. In preparation of own bench testing experiment using Particle Image Velocimetry, a custom made silicone nozzle was manufactured. By using in silico computational fluid dynamics method the influence of in vitro imperfections, such as inflow variations and geometrical deviations, on the flow field were evaluated. Based on literature the throat Reynolds number was varied Rethroat = 500 ± 50. It could be shown that the flow field errors resulted from variations of inlet conditions can be largely eliminated by normalizing if the Reynolds number is known. Furthermore, a symmetric imperfection of the silicone model within manufacturing tolerance does not affect the flow as much as an asymmetric failure such as an unintended curvature of the nozzle. In brief, we can conclude that geometrical imperfection of the reference experiment should be considered accordingly to in silico modelling. The question arises, if an asymmetric benchmark for biofluid analysis needs to be established. An eccentric nozzle benchmark could be a suitable case and will be further investigated.Stiehm MichaelBrandt-Wunderlich ChristophSiewert StefanSchmitz Klaus-PeterGrabow NielsGoubergrits LeonidKühne TitusPoon Eric K. W.Ooi AndrewBarlis PeterDe Gruyterarticlecomputational fluid dynamics (cfd)fda nozzlegeometrical imperfectionasymmetryMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 78-81 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	computational fluid dynamics (cfd) fda nozzle geometrical imperfection asymmetry Medicine R
spellingShingle	computational fluid dynamics (cfd) fda nozzle geometrical imperfection asymmetry Medicine R Stiehm Michael Brandt-Wunderlich Christoph Siewert Stefan Schmitz Klaus-Peter Grabow Niels Goubergrits Leonid Kühne Titus Poon Eric K. W. Ooi Andrew Barlis Peter Sensitivity analysis of FDA´s benchmark nozzle regarding in vitro imperfections - Do we need asymmetric CFD benchmarks?
description	Modern technologies and methods such as computer simulation, so-called in silico methods, foster the development of medical devices. For accelerating the uptake of computer simulations and to increase credibility and reliability the U.S. Food and Drug Administration organized an inter-laboratory round robin study of a generic nozzle geometry. In preparation of own bench testing experiment using Particle Image Velocimetry, a custom made silicone nozzle was manufactured. By using in silico computational fluid dynamics method the influence of in vitro imperfections, such as inflow variations and geometrical deviations, on the flow field were evaluated. Based on literature the throat Reynolds number was varied Rethroat = 500 ± 50. It could be shown that the flow field errors resulted from variations of inlet conditions can be largely eliminated by normalizing if the Reynolds number is known. Furthermore, a symmetric imperfection of the silicone model within manufacturing tolerance does not affect the flow as much as an asymmetric failure such as an unintended curvature of the nozzle. In brief, we can conclude that geometrical imperfection of the reference experiment should be considered accordingly to in silico modelling. The question arises, if an asymmetric benchmark for biofluid analysis needs to be established. An eccentric nozzle benchmark could be a suitable case and will be further investigated.
format	article
author	Stiehm Michael Brandt-Wunderlich Christoph Siewert Stefan Schmitz Klaus-Peter Grabow Niels Goubergrits Leonid Kühne Titus Poon Eric K. W. Ooi Andrew Barlis Peter
author_facet	Stiehm Michael Brandt-Wunderlich Christoph Siewert Stefan Schmitz Klaus-Peter Grabow Niels Goubergrits Leonid Kühne Titus Poon Eric K. W. Ooi Andrew Barlis Peter
author_sort	Stiehm Michael
title	Sensitivity analysis of FDA´s benchmark nozzle regarding in vitro imperfections - Do we need asymmetric CFD benchmarks?
title_short	Sensitivity analysis of FDA´s benchmark nozzle regarding in vitro imperfections - Do we need asymmetric CFD benchmarks?
title_full	Sensitivity analysis of FDA´s benchmark nozzle regarding in vitro imperfections - Do we need asymmetric CFD benchmarks?
title_fullStr	Sensitivity analysis of FDA´s benchmark nozzle regarding in vitro imperfections - Do we need asymmetric CFD benchmarks?
title_full_unstemmed	Sensitivity analysis of FDA´s benchmark nozzle regarding in vitro imperfections - Do we need asymmetric CFD benchmarks?
title_sort	sensitivity analysis of fda´s benchmark nozzle regarding in vitro imperfections - do we need asymmetric cfd benchmarks?
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/c22ccd023c4a4a319f78c935001a79e8
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Sensitivity analysis of FDA´s benchmark nozzle regarding in vitro imperfections - Do we need asymmetric CFD benchmarks?

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